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Q7U7H8 (AROA_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:SYNW1005
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4414413-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000325392

Sequences

Sequence LengthMass (Da)Tools
Q7U7H8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 05C0DE43D080F0B4

FASTA44146,057
        10         20         30         40         50         60 
MSANGPSHPA RELKAGGSLS GHVKVPGDKS ISHRSLLFGA IAEGTTTIDG LLPAEDPIST 

        70         80         90        100        110        120 
AACLRAMGVL ISPIEAAGLV TVEGVGLDGL QEPAEILDCG NSGTTMRLML GLLAGRAGRH 

       130        140        150        160        170        180 
FVLDGDASLR RRPMRRVGQP LASMGADVRG RDGGNLAPLA VQGQSLRGTV IGTPVASAQV 

       190        200        210        220        230        240 
KSALLLAALT ADGTTTVIEP AQSRDHSERM LRAFGADLQV GGEMGRHITV RPGNTLKGQQ 

       250        260        270        280        290        300 
VVVPGDISSA AFWLVAGALV PGADLTIENV GLNPTRTGIL EVLEQMNAQI EVLNRRDVAG 

       310        320        330        340        350        360 
EPVGDLRITH GPLQPFSIGE EIMPRLVDEV PILSVAACFC DGESRISGAS ELRVKETDRL 

       370        380        390        400        410        420 
AVMARQLKAM GAEIEEHEDG MTIHGGRPLK GAALDSETDH RVAMSLAVAS LLASGDSTLQ 

       430        440 
RSDAAAVSYP SFWDDLDRLR C

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References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX569691 Genomic DNA. Translation: CAE07520.1.
RefSeqNP_897098.1. NC_005070.1.

3D structure databases

HSSPHSSP built from PDB template 1RF6 based on UniProtKB Q9S400.
ProteinModelPortalQ7U7H8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7U7H8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1730202.
GenomeReviewsGene locus SYNW1005 in contig BX548020_GR.
KEGGsyw:SYNW1005.
PATRIC23833483. VBISynSp27240_1046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHBG646626.
OMALECANIS.
PhylomeDBQ7U7H8.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycSSP84588:SYNW1005OR3541-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_SYNPX
AccessionPrimary (citable) accession number: Q7U7H8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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