Q7U770 (FBSB_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase
Short name=FBPase class 2/SBPase
EC=3.1.3.11
EC=3.1.3.37

Gene names

Ordered Locus Names:

SYNW1116

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively By similarity.
Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. Sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.
Cofactor	Manganese By similarity.
Pathway	Carbohydrate biosynthesis; Calvin cycle.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the FBPase class 2 family.

Ontologies

Keywords
Biological process	Calvin cycle Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: InterPro reductive pentose-phosphate cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sedoheptulose-bisphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase		PRO_0000342734
Regions
	Region	88 – 90	3	Substrate binding By similarity
	Region	164 – 166	3	Substrate binding By similarity
	Region	186 – 188	3	Substrate binding By similarity
Sites
	Metal binding	33	1	Manganese 1 By similarity
	Metal binding	57	1	Manganese 1 By similarity
	Metal binding	85	1	Manganese 2 By similarity
	Metal binding	88	1	Manganese 2 By similarity
	Metal binding	213	1	Manganese 2 By similarity
	Binding site	119	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7U770 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 54659F835F29E7C7	FASTA	334	35,204
	10 20 30 40 50 60 MDQTLIQEIL EVVEQAAIAS AKLSGKGLKN EADAAAVEAM RKRMGQIQMQ GRIVIGEGER 70 80 90 100 110 120 DEAPMLYIGE EVGSGTGPGV DFAVDPCEGT NLCAFNQRGS MAVLAASDRG GLFNAPDFYM 130 140 150 160 170 180 KKLAAPPAAK GKVDIRKSAT ENIKILSECL GLAVDELTIV VMDRARHKDL IAEIRATGAR 190 200 210 220 230 240 IQPISDGDVQ AAIACGFAGT GTHCLMGIGA APEGVISAAA MRALGGHFQG QLVYDPAVAQ 250 260 270 280 290 300 TSEWADMTKE GNLARLAEMG ITDPDKVYEA EELACGEHVC FAGSGITDGL LFHGVKFERD 310 320 330 CTRTSSLVIS NLDNTCRFTN TVHIKDGAQS IALS

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569692 Genomic DNA. Translation: CAE07631.1.
RefSeq	NP_897209.1. NC_005070.1.
3D structure databases
HSSP	HSSP built from PDB template 1NI9 based on UniProtKB P0A9C9.
ProteinModelPortal	Q7U770.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U770.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1730416.
GenomeReviews	Gene locus SYNW1116 in contig BX548020_GR.
KEGG	syw:SYNW1116.
PATRIC	23833733. VBISynSp27240_1170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1494.
HOGENOM	HBG284837.
OMA	TSEWADM.
PhylomeDB	Q7U770.
ProtClustDB	PRK09479.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW1116OR0125-MONOMER.
Family and domain databases
InterPro	IPR004464. FBPase_class-2/SBPase. [Graphical view]
KO	K11532.
Pfam	PF03320. FBPase_glpX. 1 hit. [Graphical view]
PIRSF	PIRSF004532. GlpX. 1 hit.
TIGRFAMs	TIGR00330. GlpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FBSB_SYNPX

Accession

Primary (citable) accession number: Q7U770

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program