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Q7U6Y8 (ACSF_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81
Gene names
Name:acsF
Ordered Locus Names:SYNW1198
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
PRO_0000217538

Sequences

Sequence LengthMass (Da)Tools
Q7U6Y8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7A5F8C163703EE0B

FASTA35641,413
        10         20         30         40         50         60 
MVPPTAVAEA NAVATKDPVK DTILTPRFYT TDFDDMAAMD LRPNEAELEA ICEEFRKDYN 

        70         80         90        100        110        120 
RHHFVRNDDF DGAADKLDPE TRRVFVEFLE QSCTSEFSGF LLYKELSRRI KQQNPLLAEC 

       130        140        150        160        170        180 
FAHMARDEAR HAGFLNKAMS DFGMQLDLGF LTANKDYTFF QPKFIFYATY LSEKIGYWRY 

       190        200        210        220        230        240 
IAIYRHLEKN PESKIFPIFN FFENWCQDEN RHGDFFDALM KSQPDTVRGP IAKLWCRFFL 

       250        260        270        280        290        300 
LAVFATMYVR DVARKEFYEA LGLDARTYDK MVIEKTNETT ARVFPVVLDV NNPKFWTRLE 

       310        320        330        340        350 
RLVENNAALE AADRSSSPAP LKLFKKLPRW ISNGAEMAKL FLMSPIDSAK FQPAVR

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX569692 Genomic DNA. Translation: CAE07713.1.
RefSeqNP_897291.1. NC_005070.1.

3D structure databases

ProteinModelPortalQ7U6Y8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7U6Y8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1731553.
GenomeReviewsGene locus SYNW1198 in contig BX548020_GR.
KEGGsyw:SYNW1198.
PATRIC23833910. VBISynSp27240_1257.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
OMAHGDFFDA.
PhylomeDBQ7U6Y8.
ProtClustDBPRK13654.

Enzyme and pathway databases

BioCycSSP84588:SYNW1198OR3403-MONOMER.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF_SYNPX
AccessionPrimary (citable) accession number: Q7U6Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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