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Q7U6T1

- SYL_SYNPX

UniProt

Q7U6T1 - SYL_SYNPX

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Protein
Leucine--tRNA ligase
Gene
leuS, SYNW1255
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei619 – 6191ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SYNW1255
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligaseUniRule annotation
PRO_0000152104Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1255.

Structurei

3D structure databases

ProteinModelPortaliQ7U6T1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi616 – 6205"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U6T1-1 [UniParc]FASTAAdd to Basket

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MNSRYSPADL EQRWQTTWRS EGLDVTPEPE DGKGFYALSM FPYPSGTLHM    50
GHVRNYVITD VIARVQRMRG HSVLHPMGWD AFGLPAENAA IERNVDPGDW 100
TDRNIDQMRS QLDRLGLSID WDREQATCHS DYYRWTQWLF LELFDGGLAY 150
RKNATVNWDP VDQTVLANEQ VDADGRSWRS GALVEQRQLN QWFLRITQYA 200
EALLNDLDQL SGWPERVRTM QANWIGRSEG AEIQFKVSSD SDTTITVFTT 250
RPDTLAGASC VVLAPDHPLV NSLTSPDQQD VVQAFQAEVA RLSALERTSD 300
DAPKRGVFTG ATVLNPLNGR ALPVWIADYV LVDYGTGAVM GVPAHDQRDR 350
RFAQSYGLAV QQVIEAEGAA AAIAAGEAWT DPGVLIHSGD FDGLNSIEAK 400
ERITRHGEQQ GWAVAKVTYR LRDWLISRQR YWGCPIPIIH CPSCGAVPVP 450
REDLPVVLPR GIDLSGKGGS PLEQQQDWVN VPCPSCGEPA KRETDTMDTF 500
MCSSWYFLRF ADPHNTEQPF SREAVNRWLP VQQYVGGIEH AILHLLYSRF 550
FTKALKDRGL IDVAEPFDRL LTQGMVQGTT YRNPSTGKYV ASADVSDPET 600
PTDPTSGEPL EVLFEKMSKS KYNGVDPAAV IDRYGADTAR MFILFKAPPE 650
KDLEWDDSDV EGQFRFLQRI WRLVESADSR IDSLEPEERP EPLADTDAKV 700
RRAIHIAIDA VSEDLQDEIQ LNTAISELMK LTNAITSVGV AELSTSVLKE 750
ALSTLLRLLA PFAPHLAEEL WHQLGGTSSV HRAGWPELDP SALVQDSVDL 800
VIQIKGKVRG TIQVPAAADK EQLEALALAS EIAAKWLEGH PPRRVIVVPG 850
KLVNLVP 857
Length:857
Mass (Da):95,500
Last modified:October 1, 2003 - v1
Checksum:i84F8D503B0096EC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569692 Genomic DNA. Translation: CAE07770.1.
RefSeqiNP_897348.1. NC_005070.1.
WP_011128119.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07770; CAE07770; SYNW1255.
GeneIDi1731539.
KEGGisyw:SYNW1255.
PATRICi23834030. VBISynSp27240_1316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569692 Genomic DNA. Translation: CAE07770.1 .
RefSeqi NP_897348.1. NC_005070.1.
WP_011128119.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U6T1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 84588.SYNW1255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE07770 ; CAE07770 ; SYNW1255 .
GeneIDi 1731539.
KEGGi syw:SYNW1255.
PATRICi 23834030. VBISynSp27240_1316.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiSYL_SYNPX
AccessioniPrimary (citable) accession number: Q7U6T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi