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Q7U6T1

- SYL_SYNPX

UniProt

Q7U6T1 - SYL_SYNPX

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei619 – 6191ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SYNW1255
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Leucine--tRNA ligasePRO_0000152104Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW1255.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U6T1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi616 – 6205"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7U6T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSRYSPADL EQRWQTTWRS EGLDVTPEPE DGKGFYALSM FPYPSGTLHM    50
    GHVRNYVITD VIARVQRMRG HSVLHPMGWD AFGLPAENAA IERNVDPGDW 100
    TDRNIDQMRS QLDRLGLSID WDREQATCHS DYYRWTQWLF LELFDGGLAY 150
    RKNATVNWDP VDQTVLANEQ VDADGRSWRS GALVEQRQLN QWFLRITQYA 200
    EALLNDLDQL SGWPERVRTM QANWIGRSEG AEIQFKVSSD SDTTITVFTT 250
    RPDTLAGASC VVLAPDHPLV NSLTSPDQQD VVQAFQAEVA RLSALERTSD 300
    DAPKRGVFTG ATVLNPLNGR ALPVWIADYV LVDYGTGAVM GVPAHDQRDR 350
    RFAQSYGLAV QQVIEAEGAA AAIAAGEAWT DPGVLIHSGD FDGLNSIEAK 400
    ERITRHGEQQ GWAVAKVTYR LRDWLISRQR YWGCPIPIIH CPSCGAVPVP 450
    REDLPVVLPR GIDLSGKGGS PLEQQQDWVN VPCPSCGEPA KRETDTMDTF 500
    MCSSWYFLRF ADPHNTEQPF SREAVNRWLP VQQYVGGIEH AILHLLYSRF 550
    FTKALKDRGL IDVAEPFDRL LTQGMVQGTT YRNPSTGKYV ASADVSDPET 600
    PTDPTSGEPL EVLFEKMSKS KYNGVDPAAV IDRYGADTAR MFILFKAPPE 650
    KDLEWDDSDV EGQFRFLQRI WRLVESADSR IDSLEPEERP EPLADTDAKV 700
    RRAIHIAIDA VSEDLQDEIQ LNTAISELMK LTNAITSVGV AELSTSVLKE 750
    ALSTLLRLLA PFAPHLAEEL WHQLGGTSSV HRAGWPELDP SALVQDSVDL 800
    VIQIKGKVRG TIQVPAAADK EQLEALALAS EIAAKWLEGH PPRRVIVVPG 850
    KLVNLVP 857
    Length:857
    Mass (Da):95,500
    Last modified:October 1, 2003 - v1
    Checksum:i84F8D503B0096EC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569692 Genomic DNA. Translation: CAE07770.1.
    RefSeqiNP_897348.1. NC_005070.1.
    WP_011128119.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07770; CAE07770; SYNW1255.
    GeneIDi1731539.
    KEGGisyw:SYNW1255.
    PATRICi23834030. VBISynSp27240_1316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569692 Genomic DNA. Translation: CAE07770.1 .
    RefSeqi NP_897348.1. NC_005070.1.
    WP_011128119.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U6T1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW1255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07770 ; CAE07770 ; SYNW1255 .
    GeneIDi 1731539.
    KEGGi syw:SYNW1255.
    PATRICi 23834030. VBISynSp27240_1316.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiSYL_SYNPX
    AccessioniPrimary (citable) accession number: Q7U6T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3