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Q7U6T1

- SYL_SYNPX

UniProt

Q7U6T1 - SYL_SYNPX

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei619 – 6191ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SYNW1255
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligasePRO_0000152104Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1255.

Structurei

3D structure databases

ProteinModelPortaliQ7U6T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi616 – 6205"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U6T1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSRYSPADL EQRWQTTWRS EGLDVTPEPE DGKGFYALSM FPYPSGTLHM
60 70 80 90 100
GHVRNYVITD VIARVQRMRG HSVLHPMGWD AFGLPAENAA IERNVDPGDW
110 120 130 140 150
TDRNIDQMRS QLDRLGLSID WDREQATCHS DYYRWTQWLF LELFDGGLAY
160 170 180 190 200
RKNATVNWDP VDQTVLANEQ VDADGRSWRS GALVEQRQLN QWFLRITQYA
210 220 230 240 250
EALLNDLDQL SGWPERVRTM QANWIGRSEG AEIQFKVSSD SDTTITVFTT
260 270 280 290 300
RPDTLAGASC VVLAPDHPLV NSLTSPDQQD VVQAFQAEVA RLSALERTSD
310 320 330 340 350
DAPKRGVFTG ATVLNPLNGR ALPVWIADYV LVDYGTGAVM GVPAHDQRDR
360 370 380 390 400
RFAQSYGLAV QQVIEAEGAA AAIAAGEAWT DPGVLIHSGD FDGLNSIEAK
410 420 430 440 450
ERITRHGEQQ GWAVAKVTYR LRDWLISRQR YWGCPIPIIH CPSCGAVPVP
460 470 480 490 500
REDLPVVLPR GIDLSGKGGS PLEQQQDWVN VPCPSCGEPA KRETDTMDTF
510 520 530 540 550
MCSSWYFLRF ADPHNTEQPF SREAVNRWLP VQQYVGGIEH AILHLLYSRF
560 570 580 590 600
FTKALKDRGL IDVAEPFDRL LTQGMVQGTT YRNPSTGKYV ASADVSDPET
610 620 630 640 650
PTDPTSGEPL EVLFEKMSKS KYNGVDPAAV IDRYGADTAR MFILFKAPPE
660 670 680 690 700
KDLEWDDSDV EGQFRFLQRI WRLVESADSR IDSLEPEERP EPLADTDAKV
710 720 730 740 750
RRAIHIAIDA VSEDLQDEIQ LNTAISELMK LTNAITSVGV AELSTSVLKE
760 770 780 790 800
ALSTLLRLLA PFAPHLAEEL WHQLGGTSSV HRAGWPELDP SALVQDSVDL
810 820 830 840 850
VIQIKGKVRG TIQVPAAADK EQLEALALAS EIAAKWLEGH PPRRVIVVPG

KLVNLVP
Length:857
Mass (Da):95,500
Last modified:October 1, 2003 - v1
Checksum:i84F8D503B0096EC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569692 Genomic DNA. Translation: CAE07770.1.
RefSeqiNP_897348.1. NC_005070.1.
WP_011128119.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07770; CAE07770; SYNW1255.
GeneIDi1731539.
KEGGisyw:SYNW1255.
PATRICi23834030. VBISynSp27240_1316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569692 Genomic DNA. Translation: CAE07770.1 .
RefSeqi NP_897348.1. NC_005070.1.
WP_011128119.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U6T1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW1255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE07770 ; CAE07770 ; SYNW1255 .
GeneIDi 1731539.
KEGGi syw:SYNW1255.
PATRICi 23834030. VBISynSp27240_1316.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiSYL_SYNPX
AccessioniPrimary (citable) accession number: Q7U6T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3