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Q7U6T1 (SYL_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SYNW1255
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length857 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 857857Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152104

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif616 – 6205"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6191ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U6T1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 84F8D503B0096EC3

FASTA85795,500
        10         20         30         40         50         60 
MNSRYSPADL EQRWQTTWRS EGLDVTPEPE DGKGFYALSM FPYPSGTLHM GHVRNYVITD 

        70         80         90        100        110        120 
VIARVQRMRG HSVLHPMGWD AFGLPAENAA IERNVDPGDW TDRNIDQMRS QLDRLGLSID 

       130        140        150        160        170        180 
WDREQATCHS DYYRWTQWLF LELFDGGLAY RKNATVNWDP VDQTVLANEQ VDADGRSWRS 

       190        200        210        220        230        240 
GALVEQRQLN QWFLRITQYA EALLNDLDQL SGWPERVRTM QANWIGRSEG AEIQFKVSSD 

       250        260        270        280        290        300 
SDTTITVFTT RPDTLAGASC VVLAPDHPLV NSLTSPDQQD VVQAFQAEVA RLSALERTSD 

       310        320        330        340        350        360 
DAPKRGVFTG ATVLNPLNGR ALPVWIADYV LVDYGTGAVM GVPAHDQRDR RFAQSYGLAV 

       370        380        390        400        410        420 
QQVIEAEGAA AAIAAGEAWT DPGVLIHSGD FDGLNSIEAK ERITRHGEQQ GWAVAKVTYR 

       430        440        450        460        470        480 
LRDWLISRQR YWGCPIPIIH CPSCGAVPVP REDLPVVLPR GIDLSGKGGS PLEQQQDWVN 

       490        500        510        520        530        540 
VPCPSCGEPA KRETDTMDTF MCSSWYFLRF ADPHNTEQPF SREAVNRWLP VQQYVGGIEH 

       550        560        570        580        590        600 
AILHLLYSRF FTKALKDRGL IDVAEPFDRL LTQGMVQGTT YRNPSTGKYV ASADVSDPET 

       610        620        630        640        650        660 
PTDPTSGEPL EVLFEKMSKS KYNGVDPAAV IDRYGADTAR MFILFKAPPE KDLEWDDSDV 

       670        680        690        700        710        720 
EGQFRFLQRI WRLVESADSR IDSLEPEERP EPLADTDAKV RRAIHIAIDA VSEDLQDEIQ 

       730        740        750        760        770        780 
LNTAISELMK LTNAITSVGV AELSTSVLKE ALSTLLRLLA PFAPHLAEEL WHQLGGTSSV 

       790        800        810        820        830        840 
HRAGWPELDP SALVQDSVDL VIQIKGKVRG TIQVPAAADK EQLEALALAS EIAAKWLEGH 

       850 
PPRRVIVVPG KLVNLVP 

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX569692 Genomic DNA. Translation: CAE07770.1.
RefSeqNP_897348.1. NC_005070.1.

3D structure databases

ProteinModelPortalQ7U6T1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING84588.SYNW1255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE07770; CAE07770; SYNW1255.
GeneID1731539.
KEGGsyw:SYNW1255.
PATRIC23834030. VBISynSp27240_1316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNPX
AccessionPrimary (citable) accession number: Q7U6T1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries