Q7U6S4 (ARGC_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	SYNW1262

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112463
Sites
	Active site	160	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7U6S4 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 26BD4BCFD8B2F200	FASTA	357	38,350
	10 20 30 40 50 60 MAGGGQGRVA VIGASGYGGL QTIRLLQDHP SLTVTFLGGE RSAGRRWSSI CSFLPLPEDP 70 80 90 100 110 120 VVQSADAERI AAAADYAVLS LPNGLACQLA PELLQRGVRV VDLSADFRYR SLEQWSQVYA 130 140 150 160 170 180 QEANRLSRED SELCQQAVYG LPEWHGPAIA EARLVAAPGC FPTASLLPLL PFLKQGLIDT 190 200 210 220 230 240 DGIVIDAKTG TSGGGRVPKE AMLLAEASES IAPYGVIGHR HTSEIEQMAR EVAGQDVRLQ 250 260 270 280 290 300 FTPHLVPMVR GLLSTVYARL RDPGLTAEDC TTVLEAVYRH HPCVSVLPVG TYPATKWARH 310 320 330 340 350 TNRALVSVQV DTRTGQMILM SAIDNLIKGQ AGQGVQCLNL MHGLPPETGL PLQSFYP

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569692 Genomic DNA. Translation: CAE07777.1.
RefSeq	NP_897355.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U6S4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U6S4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1730442.
GenomeReviews	Gene locus SYNW1262 in contig BX548020_GR.
KEGG	syw:SYNW1262.
PATRIC	23834046. VBISynSp27240_1324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q7U6S4.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW1262OR3348-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_SYNPX

Accession

Primary (citable) accession number: Q7U6S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program