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Q7U6M8 (AROB_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:SYNW1310
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3713713-dehydroquinate synthase HAMAP MF_00110
PRO_0000140799

Sequences

Sequence LengthMass (Da)Tools
Q7U6M8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: C7F550F6155D74E6

FASTA37139,591
        10         20         30         40         50         60 
MVSSPTLRRI AVALERNPYE VVIGAGGLSR LGDELLKAGI QPGRRILVVS NPDVAAPYGE 

        70         80         90        100        110        120 
GCLQSLRQQG FHADLLVIDA GEERKTPATV AAIHDSAFEQ RLERSSLMLA LGGGVVGDMT 

       130        140        150        160        170        180 
GFAAATWLRG IQVIQVPTTL LAMVDAAIGG KTGVNHPGGK NLIGAFHQPS LVLIDPETLN 

       190        200        210        220        230        240 
TLPEREFRAG MAEVIKYGIL GDPALFQCLE EGPEPNSAAG LGNSRLETIL ERSAAAKARV 

       250        260        270        280        290        300 
VAADEREGGL RAVLNYGHTF GHVVETLCGY GTWLHGEAVA IGMVAVGQLA VNRGSWTADE 

       310        320        330        340        350        360 
AGRQTQLIQR CGLPTAWPDL DPDAVLRTLQ GDKKVKDGRL RFVLPMAIGR VEIRDDISRD 

       370 
EILHCLDQLR G

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX569692 Genomic DNA. Translation: CAE07825.1.
RefSeqNP_897403.1. NC_005070.1.

3D structure databases

ProteinModelPortalQ7U6M8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7U6M8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1731226.
GenomeReviewsGene locus SYNW1310 in contig BX548020_GR.
KEGGsyw:SYNW1310.
PATRIC23834152. VBISynSp27240_1376.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ7U6M8.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycSSP84588:SYNW1310OR0258-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_SYNPX
AccessionPrimary (citable) accession number: Q7U6M8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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