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Q7U635

- HIS2_SYNPX

UniProt

Q7U635 - HIS2_SYNPX

Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-HAMAP
    3. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00007.
    UPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine biosynthesis bifunctional protein HisIEUniRule annotation
    Including the following 2 domains:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
    Short name:
    PRA-PHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Synonyms:hisIEUniRule annotation
    Ordered Locus Names:SYNW1505
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Histidine biosynthesis bifunctional protein HisIEPRO_0000136439Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW1505.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U635.
    SMRiQ7U635. Positions 11-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 128128Phosphoribosyl-AMP cyclohydrolaseAdd
    BLAST
    Regioni129 – 22294Phosphoribosyl-ATP pyrophosphohydrolaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the PRA-CH family.UniRule annotation
    In the C-terminal section; belongs to the PRA-PH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0140.
    HOGENOMiHOG000277503.
    KOiK11755.
    OMAiSITPDCD.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01019. HisIE.
    MF_01020. HisE.
    MF_01021. HisI.
    InterProiIPR023019. His_synth_HisIE.
    IPR026660. PRA-CH.
    IPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    PF01503. PRA-PH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPLSPAFID QLRFNEAGLI PAIAQDWLDG AVLMVAWMNR ESIQQTLNSG    50
    EAHYWSRSRQ ELWHKGATSG HTQTLRSIRY DCDADVLLLT IEQRGDIACH 100
    TGARSCFYEG GDQRSDGGSN ALSPPADACT ELFRVIESRR DNPEEGSYTN 150
    KLLEGGDNKI LKKIGEESAE FVMACKDDNP EEIAGEAADI LFHMQVALAH 200
    HGVSWRQVQE VLAARRGAPR RH 222
    Length:222
    Mass (Da):24,704
    Last modified:October 1, 2003 - v1
    Checksum:i36F5CDFBCB2251F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569693 Genomic DNA. Translation: CAE08020.1.
    RefSeqiNP_897598.1. NC_005070.1.
    WP_011128369.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE08020; CAE08020; SYNW1505.
    GeneIDi1730396.
    KEGGisyw:SYNW1505.
    PATRICi23834634. VBISynSp27240_1617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569693 Genomic DNA. Translation: CAE08020.1 .
    RefSeqi NP_897598.1. NC_005070.1.
    WP_011128369.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U635.
    SMRi Q7U635. Positions 11-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW1505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE08020 ; CAE08020 ; SYNW1505 .
    GeneIDi 1730396.
    KEGGi syw:SYNW1505.
    PATRICi 23834634. VBISynSp27240_1617.

    Phylogenomic databases

    eggNOGi COG0140.
    HOGENOMi HOG000277503.
    KOi K11755.
    OMAi SITPDCD.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00007 .
    UPA00031 ; UER00008 .

    Family and domain databases

    HAMAPi MF_01019. HisIE.
    MF_01020. HisE.
    MF_01021. HisI.
    InterProi IPR023019. His_synth_HisIE.
    IPR026660. PRA-CH.
    IPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    PF01503. PRA-PH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiHIS2_SYNPX
    AccessioniPrimary (citable) accession number: Q7U635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3