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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Pathway: L-histidine biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
UPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIEUniRule annotation
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Synonyms:hisIEUniRule annotation
Ordered Locus Names:SYNW1505
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Histidine biosynthesis bifunctional protein HisIEPRO_0000136439Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1505.

Structurei

3D structure databases

ProteinModelPortaliQ7U635.
SMRiQ7U635. Positions 11-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 128128Phosphoribosyl-AMP cyclohydrolaseAdd
BLAST
Regioni129 – 22294Phosphoribosyl-ATP pyrophosphohydrolaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.UniRule annotation
In the C-terminal section; belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000277503.
KOiK11755.
OMAiVVVQHAV.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProiIPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLSPAFID QLRFNEAGLI PAIAQDWLDG AVLMVAWMNR ESIQQTLNSG
60 70 80 90 100
EAHYWSRSRQ ELWHKGATSG HTQTLRSIRY DCDADVLLLT IEQRGDIACH
110 120 130 140 150
TGARSCFYEG GDQRSDGGSN ALSPPADACT ELFRVIESRR DNPEEGSYTN
160 170 180 190 200
KLLEGGDNKI LKKIGEESAE FVMACKDDNP EEIAGEAADI LFHMQVALAH
210 220
HGVSWRQVQE VLAARRGAPR RH
Length:222
Mass (Da):24,704
Last modified:October 1, 2003 - v1
Checksum:i36F5CDFBCB2251F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1.
RefSeqiNP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08020; CAE08020; SYNW1505.
KEGGisyw:SYNW1505.
PATRICi23834634. VBISynSp27240_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1.
RefSeqiNP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

3D structure databases

ProteinModelPortaliQ7U635.
SMRiQ7U635. Positions 11-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi84588.SYNW1505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE08020; CAE08020; SYNW1505.
KEGGisyw:SYNW1505.
PATRICi23834634. VBISynSp27240_1617.

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000277503.
KOiK11755.
OMAiVVVQHAV.
OrthoDBiEOG6PGKB6.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
UPA00031; UER00008.

Family and domain databases

HAMAPiMF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProiIPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiHIS2_SYNPX
AccessioniPrimary (citable) accession number: Q7U635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: May 27, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.