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Q7U635

- HIS2_SYNPX

UniProt

Q7U635 - HIS2_SYNPX

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Protein
Histidine biosynthesis bifunctional protein HisIE
Gene
hisI, hisIE, SYNW1505
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-HAMAP
  3. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
UPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIE
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Phosphoribosyl-ATP pyrophosphatase (EC:3.6.1.31)
Short name:
PRA-PH
Gene namesi
Name:hisI
Synonyms:hisIE
Ordered Locus Names:SYNW1505
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Histidine biosynthesis bifunctional protein HisIEUniRule annotation
PRO_0000136439Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1505.

Structurei

3D structure databases

ProteinModelPortaliQ7U635.
SMRiQ7U635. Positions 11-111.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 128128Phosphoribosyl-AMP cyclohydrolaseUniRule annotation
Add
BLAST
Regioni129 – 22294Phosphoribosyl-ATP pyrophosphohydrolaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.
In the C-terminal section; belongs to the PRA-PH family.

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000277503.
KOiK11755.
OMAiSITPDCD.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProiIPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U635-1 [UniParc]FASTAAdd to Basket

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MQPLSPAFID QLRFNEAGLI PAIAQDWLDG AVLMVAWMNR ESIQQTLNSG    50
EAHYWSRSRQ ELWHKGATSG HTQTLRSIRY DCDADVLLLT IEQRGDIACH 100
TGARSCFYEG GDQRSDGGSN ALSPPADACT ELFRVIESRR DNPEEGSYTN 150
KLLEGGDNKI LKKIGEESAE FVMACKDDNP EEIAGEAADI LFHMQVALAH 200
HGVSWRQVQE VLAARRGAPR RH 222
Length:222
Mass (Da):24,704
Last modified:October 1, 2003 - v1
Checksum:i36F5CDFBCB2251F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1.
RefSeqiNP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08020; CAE08020; SYNW1505.
GeneIDi1730396.
KEGGisyw:SYNW1505.
PATRICi23834634. VBISynSp27240_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1 .
RefSeqi NP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U635.
SMRi Q7U635. Positions 11-111.
ModBasei Search...

Protein-protein interaction databases

STRINGi 84588.SYNW1505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08020 ; CAE08020 ; SYNW1505 .
GeneIDi 1730396.
KEGGi syw:SYNW1505.
PATRICi 23834634. VBISynSp27240_1617.

Phylogenomic databases

eggNOGi COG0140.
HOGENOMi HOG000277503.
KOi K11755.
OMAi SITPDCD.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00007 .
UPA00031 ; UER00008 .

Family and domain databases

HAMAPi MF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProi IPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiHIS2_SYNPX
AccessioniPrimary (citable) accession number: Q7U635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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