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Q7U635

- HIS2_SYNPX

UniProt

Q7U635 - HIS2_SYNPX

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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-HAMAP
  3. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
UPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIEUniRule annotation
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Synonyms:hisIEUniRule annotation
Ordered Locus Names:SYNW1505
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Histidine biosynthesis bifunctional protein HisIEPRO_0000136439Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1505.

Structurei

3D structure databases

ProteinModelPortaliQ7U635.
SMRiQ7U635. Positions 11-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 128128Phosphoribosyl-AMP cyclohydrolaseAdd
BLAST
Regioni129 – 22294Phosphoribosyl-ATP pyrophosphohydrolaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.UniRule annotation
In the C-terminal section; belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000277503.
KOiK11755.
OMAiSITPDCD.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProiIPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPLSPAFID QLRFNEAGLI PAIAQDWLDG AVLMVAWMNR ESIQQTLNSG
60 70 80 90 100
EAHYWSRSRQ ELWHKGATSG HTQTLRSIRY DCDADVLLLT IEQRGDIACH
110 120 130 140 150
TGARSCFYEG GDQRSDGGSN ALSPPADACT ELFRVIESRR DNPEEGSYTN
160 170 180 190 200
KLLEGGDNKI LKKIGEESAE FVMACKDDNP EEIAGEAADI LFHMQVALAH
210 220
HGVSWRQVQE VLAARRGAPR RH
Length:222
Mass (Da):24,704
Last modified:October 1, 2003 - v1
Checksum:i36F5CDFBCB2251F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1.
RefSeqiNP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08020; CAE08020; SYNW1505.
GeneIDi1730396.
KEGGisyw:SYNW1505.
PATRICi23834634. VBISynSp27240_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569693 Genomic DNA. Translation: CAE08020.1 .
RefSeqi NP_897598.1. NC_005070.1.
WP_011128369.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U635.
SMRi Q7U635. Positions 11-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW1505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08020 ; CAE08020 ; SYNW1505 .
GeneIDi 1730396.
KEGGi syw:SYNW1505.
PATRICi 23834634. VBISynSp27240_1617.

Phylogenomic databases

eggNOGi COG0140.
HOGENOMi HOG000277503.
KOi K11755.
OMAi SITPDCD.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00007 .
UPA00031 ; UER00008 .

Family and domain databases

HAMAPi MF_01019. HisIE.
MF_01020. HisE.
MF_01021. HisI.
InterProi IPR023019. His_synth_HisIE.
IPR026660. PRA-CH.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiHIS2_SYNPX
AccessioniPrimary (citable) accession number: Q7U635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3