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Q7U618 (PYRC_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase
Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:SYNW1523
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219

Subunit structure

Homodimer By similarity. HAMAP MF_00219

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Dihydroorotase HAMAP MF_00219
PRO_1000024068

Sites

Metal binding141Zinc 1 By similarity
Metal binding161Zinc 1 By similarity
Metal binding1001Zinc 1; via carbamate group By similarity
Metal binding1001Zinc 2; via carbamate group By similarity
Metal binding1371Zinc 2 By similarity
Metal binding1751Zinc 2 By similarity
Metal binding2481Zinc 1 By similarity

Amino acid modifications

Modified residue1001N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U618 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 924FC7E5C313E522

FASTA34338,069
        10         20         30         40         50         60 
MAEQLTITAP DDWHVHLRDE EMLERVVAYT ARCFRRAIVM PNLRPPVTTV DAARSYRDRI 

        70         80         90        100        110        120 
LSACPEGVAF TPLMTAYLTD NSDPDDLERG FQEGVYTAAK LYPANATTNS AAGVTDLDQI 

       130        140        150        160        170        180 
GRVLSRMEAI GMPLLIHGEV TDADVDVFDR EAVFIERHLK SLRTRHPELK VVFEHITTEQ 

       190        200        210        220        230        240 
AVDYVGSSDR NLAATITPHH LQINRNSMFL GGLRSDFYCL PVVKRERHRL ALRRAATSGD 

       250        260        270        280        290        300 
PRFFLGTDSA PHPRAGKETS CGCAGIFNAP FALESYAQVF AEEEAMHHLE GFASLHGPAF 

       310        320        330        340 
YGLPANNDTV TLEKVAVDVP ELVNGLVPFH AGETLPWRLQ PCM

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX569693 Genomic DNA. Translation: CAE08038.1.
RefSeqNP_897616.1. NC_005070.1.

3D structure databases

HSSPHSSP built from PDB template 1J79 based on UniProtKB P05020.
ProteinModelPortalQ7U618.
SMRQ7U618. Positions 2-340.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7U618.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1730136.
GenomeReviewsGene locus SYNW1523 in contig BX548020_GR.
KEGGsyw:SYNW1523.
PATRIC23834670. VBISynSp27240_1634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBQ7U618.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycSSP84588:SYNW1523OR3156-MONOMER.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. False negative.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_SYNPX
AccessionPrimary (citable) accession number: Q7U618
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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