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Q7U5G0 (HEMH_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SYNW1747
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Ferrochelatase HAMAP MF_00323
PRO_0000175217

Sites

Metal binding1961Iron By similarity
Metal binding2811Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U5G0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 40F4CB50014B206E

FASTA39143,785
        10         20         30         40         50         60 
MSRVGVVLLN LGGPERIQDV GPFLYNLFAD PEIIRLPSPA LQKPLAWLIS TLRSGKSQEA 

        70         80         90        100        110        120 
YRSIGGGSPL RRITEQQARE LQSLLRQRGL DATTYVAMRY WHPFTESAVA DMKADGMDEV 

       130        140        150        160        170        180 
VVLPLYPHFS ISTSGSSFRE LQRLRQGDAA FEQLPIRCIR SWFDHPGYIK AMAELIAEEV 

       190        200        210        220        230        240 
RNSDDPEKAH VFFSAHGVPK SYVEEAGDPY QQQIEACTDL IMKSLAEHMG HSNPHTLAYQ 

       250        260        270        280        290        300 
SRVGPVEWLK PYTEEALEQL GEAKTNDLVV VPISFVSEHI ETLEEIDIEY RELATEAGVV 

       310        320        330        340        350        360 
NFRRVRALDT YPPFIEGLAD LVTTSLEGPE VSLDAAAELP TKVKLYPQEK WEWGWNNSSE 

       370        380        390 
VWNGRLAMLG FSAFLLELIS GHGPLHALGL L

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX569693 Genomic DNA. Translation: CAE08262.1.
RefSeqNP_897838.1. NC_005070.1.

3D structure databases

ProteinModelPortalQ7U5G0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7U5G0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1731229.
GenomeReviewsGene locus SYNW1747 in contig BX548020_GR.
KEGGsyw:SYNW1747.
PATRIC23835169. VBISynSp27240_1879.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ7U5G0.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycSSP84588:SYNW1747OR2979-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
Gene3DG3DSA:1.10.3460.10. G3DSA:1.10.3460.10. 1 hit.
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNPX
AccessionPrimary (citable) accession number: Q7U5G0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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