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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:SYNW1826
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196781 – 477Glutamate--tRNA ligaseAdd BLAST477

Proteomic databases

PRIDEiQ7U581

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi84588.SYNW1826

Structurei

3D structure databases

ProteinModelPortaliQ7U581
SMRiQ7U581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi247 – 251"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7U581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVRLAPSP TGTLHIGTAR TAVFNWLYAR RQQGSFLLRI EDTDKERSKP
60 70 80 90 100
EYTQNILEGL RWLGIDWDEE PLIQSEQVQQ HRAAIETLLQ KGLAYRCYAN
110 120 130 140 150
EAELDAMREA QKASNQAPRY DNRHRNLTPE QEAAFQSEGR EAVIRFRIDD
160 170 180 190 200
NAEIRWNDMV RGAMSWRGAD LGGDMVVARR APADQIGDPL YNLVVVVDDA
210 220 230 240 250
AMAISHVIRG EDHIANTAKQ LLLYEALDLP APTFAHAPLI LNAEGRKLSK
260 270 280 290 300
RDGVTSINDF RTMGYTAEAI ANYMTLLGWS VPEGMEERFT LPEAAAVFSF
310 320 330 340 350
DRVNKAGARF DWDKLNWLNG QVLHALPAQQ LLDDLRPLWA EQGWTLPDDS
360 370 380 390 400
SWGLELCELL GPSLTLLKEG VEQATPFFKC PDLEDDGVRQ LEADGARTAV
410 420 430 440 450
AQLLQILEAE PWDGKDTDRA KQLLADAAKG AGVKKGVVMK SLRAALLGRL
460 470
QGPDLITTWC LLARIGEDLP RLQRCLA
Length:477
Mass (Da):53,329
Last modified:October 1, 2003 - v1
Checksum:i152F9000D56D5E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569694 Genomic DNA Translation: CAE08341.1
RefSeqiWP_011128685.1, NC_005070.1

Genome annotation databases

EnsemblBacteriaiCAE08341; CAE08341; SYNW1826
KEGGisyw:SYNW1826

Similar proteinsi

Entry informationi

Entry nameiSYE_SYNPX
AccessioniPrimary (citable) accession number: Q7U581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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