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Q7U515

- PNP_SYNPX

UniProt

Q7U515 - PNP_SYNPX

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi495 – 4951MagnesiumUniRule annotation
    Metal bindingi501 – 5011MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:SYNW1897
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Polyribonucleotide nucleotidyltransferasePRO_0000329904Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW1897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini562 – 62160KHUniRule annotationAdd
    BLAST
    Domaini631 – 69969S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7U515-1 [UniParc]FASTAAdd to Basket

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    MQGQTQSISF DGREIRLTTG RFAPQAGGSV LVECGDTAVL VTATRSGGRE    50
    GIDFLPLICD YEERLYAAGR IPGSYQRREG RPPERATLTA RLIDRPMRPL 100
    FPAWLRDDLQ VVATCLSLDE RVPADVLAVT GASIATLLAG IPFNGPMAAV 150
    RVGLLGDDFV LNPSYREIER GDLDLIVAGT PDGVVMVEAG GNQLPEQDVI 200
    EAIDFGYEAI CELIKAQEQL LKDLGIEQVK PETPTQDTTV PAYLEKQCTK 250
    AISEVLKKFD QTKDERDKAL DAIKAEAAEA IAGLKEDDAI RVATASNSKL 300
    LGNSFKALTK TLMRQQILKD GKRVDGRALD EVRAISALAG VLPRRVHGSG 350
    LFQRGLTQVL STATLGTPSD AQEMDDLHPS TEKLYLHHYN FPPYSVGETR 400
    PMRSPGRREI GHGALAERAI LPVLPAKDTF PYVVRVVSEV LSSNGSTSMG 450
    SVCGSTLSLM DAGVPLKAPV SGAAMGLIKE GDDIRILTDI QGIEDFLGDM 500
    DFKVAGSEKG ITALQMDMKI TGLPVKTIAE AINQARPARL HILEKMLEAI 550
    DTPREGLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED 600
    SGIVTIASHD GAAADEAQKI IEGLTRKVNE GEVFSGSITR IIPIGAFVEI 650
    LPGKEGMIHI SQLSEARVEK VEDVVKVGDE VTVRVREIDN RGRINLTLRG 700
    VPQSGDGAGE EPQPTPVAPL S 721
    Length:721
    Mass (Da):77,519
    Last modified:October 1, 2003 - v1
    Checksum:i6971A8B9D38978F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569694 Genomic DNA. Translation: CAE08412.1.
    RefSeqiNP_897988.1. NC_005070.1.
    WP_011128755.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE08412; CAE08412; SYNW1897.
    GeneIDi1731536.
    KEGGisyw:SYNW1897.
    PATRICi23835479. VBISynSp27240_2031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569694 Genomic DNA. Translation: CAE08412.1 .
    RefSeqi NP_897988.1. NC_005070.1.
    WP_011128755.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW1897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE08412 ; CAE08412 ; SYNW1897 .
    GeneIDi 1731536.
    KEGGi syw:SYNW1897.
    PATRICi 23835479. VBISynSp27240_2031.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiPNP_SYNPX
    AccessioniPrimary (citable) accession number: Q7U515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3