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Q7U515

- PNP_SYNPX

UniProt

Q7U515 - PNP_SYNPX

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, SYNW1897
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi495 – 4951Magnesium By similarity
Metal bindingi501 – 5011Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:SYNW1897
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329904Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW1897.

Structurei

3D structure databases

ProteinModelPortaliQ7U515.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 62160KH
Add
BLAST
Domaini631 – 69969S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U515-1 [UniParc]FASTAAdd to Basket

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MQGQTQSISF DGREIRLTTG RFAPQAGGSV LVECGDTAVL VTATRSGGRE    50
GIDFLPLICD YEERLYAAGR IPGSYQRREG RPPERATLTA RLIDRPMRPL 100
FPAWLRDDLQ VVATCLSLDE RVPADVLAVT GASIATLLAG IPFNGPMAAV 150
RVGLLGDDFV LNPSYREIER GDLDLIVAGT PDGVVMVEAG GNQLPEQDVI 200
EAIDFGYEAI CELIKAQEQL LKDLGIEQVK PETPTQDTTV PAYLEKQCTK 250
AISEVLKKFD QTKDERDKAL DAIKAEAAEA IAGLKEDDAI RVATASNSKL 300
LGNSFKALTK TLMRQQILKD GKRVDGRALD EVRAISALAG VLPRRVHGSG 350
LFQRGLTQVL STATLGTPSD AQEMDDLHPS TEKLYLHHYN FPPYSVGETR 400
PMRSPGRREI GHGALAERAI LPVLPAKDTF PYVVRVVSEV LSSNGSTSMG 450
SVCGSTLSLM DAGVPLKAPV SGAAMGLIKE GDDIRILTDI QGIEDFLGDM 500
DFKVAGSEKG ITALQMDMKI TGLPVKTIAE AINQARPARL HILEKMLEAI 550
DTPREGLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED 600
SGIVTIASHD GAAADEAQKI IEGLTRKVNE GEVFSGSITR IIPIGAFVEI 650
LPGKEGMIHI SQLSEARVEK VEDVVKVGDE VTVRVREIDN RGRINLTLRG 700
VPQSGDGAGE EPQPTPVAPL S 721
Length:721
Mass (Da):77,519
Last modified:October 1, 2003 - v1
Checksum:i6971A8B9D38978F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569694 Genomic DNA. Translation: CAE08412.1.
RefSeqiNP_897988.1. NC_005070.1.
WP_011128755.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08412; CAE08412; SYNW1897.
GeneIDi1731536.
KEGGisyw:SYNW1897.
PATRICi23835479. VBISynSp27240_2031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569694 Genomic DNA. Translation: CAE08412.1 .
RefSeqi NP_897988.1. NC_005070.1.
WP_011128755.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U515.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW1897.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08412 ; CAE08412 ; SYNW1897 .
GeneIDi 1731536.
KEGGi syw:SYNW1897.
PATRICi 23835479. VBISynSp27240_2031.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiPNP_SYNPX
AccessioniPrimary (citable) accession number: Q7U515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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