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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
ATP + (d)CMP = ADP + (d)CDP.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi277 – 285ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:SYNW2027
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001422 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397991 – 501Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST501

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW2027.

Structurei

3D structure databases

ProteinModelPortaliQ7U4P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 264Pantoate--beta-alanine ligaseAdd BLAST264
Regioni265 – 501Cytidylate kinaseAdd BLAST237

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.Curated
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
COG0414. LUCA.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiPOG091H00FM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
MF_00158. PanC. 1 hit.
MF_01349. PanCY. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U4P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTQAELAA FHSGLGQPLQ FVPTMGGLHQ GHGELIRRAA EQGPVLVSVF
60 70 80 90 100
VNPLQFAPGE DFERYPRSLE ADLALADRYG AAALWTPTVQ TIYPDGATAD
110 120 130 140 150
SARQAPAALQ QHLCGADRPG HFDGVVTVVA RLLELTRPAG LWLGEKDWQQ
160 170 180 190 200
LVILRQLVAD LVLPVKIHGV ATVREADGLA LSSRNQYLSA AQRLQAAALP
210 220 230 240 250
AALRAADGTT PLDVTRSRLS AAGLEVEYVE RVDPQSLQPC GSETALSLLA
260 270 280 290 300
AAVRCGTTRL IDHSFLMTRQ PLVAIDGPAG AGKSTVTRAF AERLGLIYLD
310 320 330 340 350
TGAMYRAVTW LVQQQGVEPG DAAAVDALLR ALDLQLQSLP GGGQQVMVNG
360 370 380 390 400
EDVSQAIRSP EVTGSVSVVA AHRCVRQALT TQQKAMGAKG GLVAEGRDIG
410 420 430 440 450
SAVFPDADLK VFLTATVAER ARRRALDLEQ RGFPVQERSE LEAQIAERDH
460 470 480 490 500
LDSTREEAPL VQAIDAVELV TDGMSIDAVI DALVEQFRAR VPEEAWPTPA

G
Length:501
Mass (Da):53,427
Last modified:October 1, 2003 - v1
Checksum:i1EA5EFDEE595D85F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569694 Genomic DNA. Translation: CAE08542.1.

Genome annotation databases

EnsemblBacteriaiCAE08542; CAE08542; SYNW2027.
KEGGisyw:SYNW2027.
PATRICi23835769. VBISynSp27240_2166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569694 Genomic DNA. Translation: CAE08542.1.

3D structure databases

ProteinModelPortaliQ7U4P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi84588.SYNW2027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE08542; CAE08542; SYNW2027.
KEGGisyw:SYNW2027.
PATRICi23835769. VBISynSp27240_2166.

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
COG0414. LUCA.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiPOG091H00FM.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
MF_00158. PanC. 1 hit.
MF_01349. PanCY. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANCY_SYNPX
AccessioniPrimary (citable) accession number: Q7U4P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.