Q7U4P0 (PANCY_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

1. Pantoate--beta-alanine ligase
   EC=6.3.2.1
   Alternative name(s):
   Pantoate-activating enzyme
   Pantothenate synthetase
2. Cytidylate kinase
   Short name=CK
   EC=2.7.4.14
   Alternative name(s):
   Cytidine monophosphate kinase
   Short name=CMP kinase

Gene names

Name:	panC/cmk
Ordered Locus Names:	SYNW2027

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_01349
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_01349
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01349.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: EC pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_01349		PRO_0000239799
Regions
	Nucleotide binding	277 – 285	9	ATP By similarity
	Region	1 – 264	264	Pantoate--beta-alanine ligase HAMAP-Rule MF_01349
	Region	265 – 501	237	Cytidylate kinase HAMAP-Rule MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q7U4P0 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1EA5EFDEE595D85F	FASTA	501	53,427
	10 20 30 40 50 60 MLSTQAELAA FHSGLGQPLQ FVPTMGGLHQ GHGELIRRAA EQGPVLVSVF VNPLQFAPGE 70 80 90 100 110 120 DFERYPRSLE ADLALADRYG AAALWTPTVQ TIYPDGATAD SARQAPAALQ QHLCGADRPG 130 140 150 160 170 180 HFDGVVTVVA RLLELTRPAG LWLGEKDWQQ LVILRQLVAD LVLPVKIHGV ATVREADGLA 190 200 210 220 230 240 LSSRNQYLSA AQRLQAAALP AALRAADGTT PLDVTRSRLS AAGLEVEYVE RVDPQSLQPC 250 260 270 280 290 300 GSETALSLLA AAVRCGTTRL IDHSFLMTRQ PLVAIDGPAG AGKSTVTRAF AERLGLIYLD 310 320 330 340 350 360 TGAMYRAVTW LVQQQGVEPG DAAAVDALLR ALDLQLQSLP GGGQQVMVNG EDVSQAIRSP 370 380 390 400 410 420 EVTGSVSVVA AHRCVRQALT TQQKAMGAKG GLVAEGRDIG SAVFPDADLK VFLTATVAER 430 440 450 460 470 480 ARRRALDLEQ RGFPVQERSE LEAQIAERDH LDSTREEAPL VQAIDAVELV TDGMSIDAVI 490 500 DALVEQFRAR VPEEAWPTPA G

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569694 Genomic DNA. Translation: CAE08542.1.
RefSeq	NP_898118.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U4P0.
ModBase	Search...
Protein-protein interaction databases
STRING	84588.SYNW2027.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE08542; CAE08542; SYNW2027.
GeneID	1730444.
KEGG	syw:SYNW2027.
PATRIC	23835769. VBISynSp27240_2166.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HOG000233355.
KO	K13799.
OMA	LGEKDWQ.
ProtClustDB	PRK13477.
Enzyme and pathway databases
UniPathway	UPA00028; UER00005.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_01349. PanCY.
InterPro	IPR004821. Cyt_trans-like. IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. IPR027417. P-loop_NTPase. IPR003721. Pantoate_ligase. IPR024894. Pantoate_ligase/cytidylate_kin. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00017. cmk. 1 hit. TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_SYNPX

Accession

Primary (citable) accession number: Q7U4P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program