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Q7U4P0

- PANCY_SYNPX

UniProt

Q7U4P0 - PANCY_SYNPX

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    ATP + (d)CMP = ADP + (d)CDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi277 – 2859ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
    Including the following 2 domains:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Cytidylate kinase (EC:2.7.4.14)
    Short name:
    CK
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name:
    CMP kinase
    Gene namesi
    Name:panC/cmk
    Ordered Locus Names:SYNW2027
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Bifunctional pantoate ligase/cytidylate kinasePRO_0000239799Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW2027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U4P0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 264264Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni265 – 501237Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.Curated
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U4P0-1 [UniParc]FASTAAdd to Basket

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    MLSTQAELAA FHSGLGQPLQ FVPTMGGLHQ GHGELIRRAA EQGPVLVSVF    50
    VNPLQFAPGE DFERYPRSLE ADLALADRYG AAALWTPTVQ TIYPDGATAD 100
    SARQAPAALQ QHLCGADRPG HFDGVVTVVA RLLELTRPAG LWLGEKDWQQ 150
    LVILRQLVAD LVLPVKIHGV ATVREADGLA LSSRNQYLSA AQRLQAAALP 200
    AALRAADGTT PLDVTRSRLS AAGLEVEYVE RVDPQSLQPC GSETALSLLA 250
    AAVRCGTTRL IDHSFLMTRQ PLVAIDGPAG AGKSTVTRAF AERLGLIYLD 300
    TGAMYRAVTW LVQQQGVEPG DAAAVDALLR ALDLQLQSLP GGGQQVMVNG 350
    EDVSQAIRSP EVTGSVSVVA AHRCVRQALT TQQKAMGAKG GLVAEGRDIG 400
    SAVFPDADLK VFLTATVAER ARRRALDLEQ RGFPVQERSE LEAQIAERDH 450
    LDSTREEAPL VQAIDAVELV TDGMSIDAVI DALVEQFRAR VPEEAWPTPA 500
    G 501
    Length:501
    Mass (Da):53,427
    Last modified:October 1, 2003 - v1
    Checksum:i1EA5EFDEE595D85F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569694 Genomic DNA. Translation: CAE08542.1.
    RefSeqiNP_898118.1. NC_005070.1.
    WP_011128885.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE08542; CAE08542; SYNW2027.
    GeneIDi1730444.
    KEGGisyw:SYNW2027.
    PATRICi23835769. VBISynSp27240_2166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569694 Genomic DNA. Translation: CAE08542.1 .
    RefSeqi NP_898118.1. NC_005070.1.
    WP_011128885.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U4P0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW2027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE08542 ; CAE08542 ; SYNW2027 .
    GeneIDi 1730444.
    KEGGi syw:SYNW2027.
    PATRICi 23835769. VBISynSp27240_2166.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiPANCY_SYNPX
    AccessioniPrimary (citable) accession number: Q7U4P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3