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Q7U4N8

- PUR5_SYNPX

UniProt

Q7U4N8 - PUR5_SYNPX

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SYNW2029
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SYNW2029
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148267Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW2029.

Structurei

3D structure databases

ProteinModelPortaliQ7U4N8.
SMRiQ7U4N8. Positions 1-339.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U4N8-1 [UniParc]FASTAAdd to Basket

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MDYKSAGVDV EAGRAFVQRI KSSVEATHRQ EVVGGLGGFG GMMRLPAGLR    50
QPLLVSGTDG VGTKLELAQD HQAHHNVGID LVAMCVNDVI TSGAQPLFFL 100
DYMATGALSP DAMAEVVEGI ADGCQQSGCS LLGGETAEMP GFYPAGRYDL 150
AGFCVAVVEE NELIDGQQVQ PGDAVIGVAS SGVHSNGFSL VRRVLAQAKA 200
DRSTLYGPDQ RPLIDDLLRP TQLYASLVKH LLSSSLPIHA MAHITGGGLP 250
ENLPRCLPTG CRAQVSPTSW ARPPLFDWLQ SAGGIPERDL WHTFNLGIGF 300
CVVVPRDQID RTVAACRAQQ LQAWPIGSIV EGNPEDGVIG LPD 343
Length:343
Mass (Da):36,300
Last modified:October 1, 2003 - v1
Checksum:i6FAC9CC72FF69245
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569694 Genomic DNA. Translation: CAE08544.1.
RefSeqiNP_898120.1. NC_005070.1.
WP_011128887.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08544; CAE08544; SYNW2029.
GeneIDi1730587.
KEGGisyw:SYNW2029.
PATRICi23835773. VBISynSp27240_2168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569694 Genomic DNA. Translation: CAE08544.1 .
RefSeqi NP_898120.1. NC_005070.1.
WP_011128887.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U4N8.
SMRi Q7U4N8. Positions 1-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW2029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08544 ; CAE08544 ; SYNW2029 .
GeneIDi 1730587.
KEGGi syw:SYNW2029.
PATRICi 23835773. VBISynSp27240_2168.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiPUR5_SYNPX
AccessioniPrimary (citable) accession number: Q7U4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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