Q7U4D2 (EFG_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	SYNW2137

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	690 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 690	690	Elongation factor G HAMAP MF_00054_B		PRO_0000091242
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7U4D2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F050590427BAF9A8	FASTA	690	75,112
	10 20 30 40 50 60 MARDFPLERV RNIGIAAHID AGKTTTTERI LFYSGVVHKI GEVHDGAAVT DWMAQERERG 70 80 90 100 110 120 ITITAAAIST SWQDHRINII DTPGHVDFTI EVERSMRVLD GVIAVFCAVG GVQPQSETVW 130 140 150 160 170 180 RQADRYSVPR MVFVNKMDRT GADFLKVHGQ IKDRLKANAV PIQLPIGAEG DLSGIIDLVG 190 200 210 220 230 240 NKAYIYKNDL GTDIEEAEIP AEMADEAAEW RATLMETIAE TDEALIEKFL ETGELSTEEL 250 260 270 280 290 300 KKGIREGVLK HGLVPMLCGS AFKNKGVQLV LDAVIDYLPA PVDVPPIQGV LPDGKEAVRP 310 320 330 340 350 360 SDDKAPFSAL AFKVMADPYG KLTFVRMYSG ILEKGSYVLN STKGEKERIS RLVVLKADDR 370 380 390 400 410 420 EEVDALRAGD LGAVLGLKNT TTGDTLCTQD DPIVLETLFI PEPVISVAVE PKTKGDMEKL 430 440 450 460 470 480 SKALVSLAEE DPTFRVNTDS ETGQTVIAGM GELHLEILVD RMLREFKVEA NIGAPQVSYR 490 500 510 520 530 540 ETIRGSAGGE GKFSRQTGGK GQYGHVVIEM EPGEPGSGFE FVNKIVGGIV PKEYIKPAEQ 550 560 570 580 590 600 GMRETCESGV IAGYPLIDVR CTLVHGSYHD VDSSEMAFKI AGSMAFKDGV KKCNPVLLEP 610 620 630 640 650 660 MMKVEVEVPE DFLGSIIGDL SSRRGQVEGQ GVEDGTSKIS AKVPLAEMFG YATELRSMTQ 670 680 690 GRGIFSMEFD NYAEVPRNVA EAIISKNQGN

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569694 Genomic DNA. Translation: CAE08652.1.
RefSeq	NP_898228.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U4D2.
SMR	Q7U4D2. Positions 4-684.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U4D2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1731270.
GenomeReviews	Gene locus SYNW2137 in contig BX548020_GR.
KEGG	syw:SYNW2137.
PATRIC	23836003. VBISynSp27240_2278.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	CNEWREK.
PhylomeDB	Q7U4D2.
ProtClustDB	PRK00007.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW2137OR2850-MONOMER.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_SYNPX

Accession

Primary (citable) accession number: Q7U4D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program