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Q7U482 (UPPP_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SYNW2189
OrganismSynechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]
Taxonomic identifier84588 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151225

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane263 – 28321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7U482 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 937390DC6FA3B095

FASTA28730,681
        10         20         30         40         50         60 
MADPSASLGL WEACWRDLVL GIVQGLTEFL PISSTAHLKV VPVLLDWGDP GVSVTAAIQL 

        70         80         90        100        110        120 
GSIVAVIAYF RRDLAQVMQG ISKAFRHGQW REPEARLGIA MAVGTLPILA VGLAIKLFWD 

       130        140        150        160        170        180 
EGYETSPLRS VPSIAVVSIV MALLLAVAER MGPRRKQLSD VSGRDGLVVG LAQVLALIPG 

       190        200        210        220        230        240 
VSRSGSTLTA SLLDGWQRAD AARFSFLLGI PAITIAGIVE LKDALAATAD AGPLPLVIGI 

       250        260        270        280 
LAATVVSWLA IDWLLKFLQR HSTWLFVAYR LLFGVGLLAW WSIHGAH 

« Hide

References

[1]"The genome of a motile marine Synechococcus."
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.
Nature 424:1037-1042(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH8102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX569694 Genomic DNA. Translation: CAE08704.1.
RefSeqNP_898280.1. NC_005070.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING84588.SYNW2189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE08704; CAE08704; SYNW2189.
GeneID1730831.
KEGGsyw:SYNW2189.
PATRIC23836125. VBISynSp27240_2334.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SYNPX
AccessionPrimary (citable) accession number: Q7U482
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families