Reviewed, UniProtKB/Swiss-Prot Q7U406 (PPNK2_SYNPX)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 2
      Short name=Poly(P)/ATP NAD kinase 2
    EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	SYNW2270

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229704

Sequences

	Sequence		Length	Mass (Da)
	Q7U406-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 824408645AC8D0B3	FASTA	316	34,715
	10 20 30 40 50 60 MRLDRVWVIY RADSQPAQRE ARQCAKELKA LGSEVTTAMS GARVNPFPGL LATQEQLPDL 70 80 90 100 110 120 AVVLGGDGTV LGAARHLAVH DIPILSINVG GHLGFLTHDR RVLRGDEIWQ RLLNDQYAME 130 140 150 160 170 180 RRMMLQAMVD RRSAEERADA PTPLQQPDVE DDDEHHWALN DFYLRAYRDE ISPTCTLELE 190 200 210 220 230 240 IDGEVVDQIR GDGLILSTPT GSTGYALAAG GPILHPGIDA IVVAPICPMS LSSRTVVVPP 250 260 270 280 290 300 RARLVIWPLG AGDHRIKLWK DGVGCTVLEP GECCVVQQAR HHAQMVQLNQ SPSYYRTVAS 310 KLHWAGSLTA AQPSHN

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX569695 Genomic DNA. Translation: CAE08785.1.
RefSeq	NP_898359.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U406.
Genome annotation databases
GeneID	1730012.
GenomeReviews	Gene locus SYNW2270 in contig BX548020_GR.
KEGG	syw:SYNW2270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7U406.
OMA	KLHWAGS.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW2270/OR2587-MON.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK2_SYNPX

Accession

Primary (citable) accession number: Q7U406

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)