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Q7U406

- NADK2_SYNPX

UniProt

Q7U406 - NADK2_SYNPX

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Protein
NAD kinase 2
Gene
nadK2, SYNW2270
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarity
Binding sitei190 – 1901NAD By similarity
Binding sitei192 – 1921NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarity
Nucleotide bindingi160 – 1612NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:SYNW2270
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316NAD kinase 2UniRule annotation
PRO_0000229704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW2270.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U406-1 [UniParc]FASTAAdd to Basket

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MRLDRVWVIY RADSQPAQRE ARQCAKELKA LGSEVTTAMS GARVNPFPGL    50
LATQEQLPDL AVVLGGDGTV LGAARHLAVH DIPILSINVG GHLGFLTHDR 100
RVLRGDEIWQ RLLNDQYAME RRMMLQAMVD RRSAEERADA PTPLQQPDVE 150
DDDEHHWALN DFYLRAYRDE ISPTCTLELE IDGEVVDQIR GDGLILSTPT 200
GSTGYALAAG GPILHPGIDA IVVAPICPMS LSSRTVVVPP RARLVIWPLG 250
AGDHRIKLWK DGVGCTVLEP GECCVVQQAR HHAQMVQLNQ SPSYYRTVAS 300
KLHWAGSLTA AQPSHN 316
Length:316
Mass (Da):34,715
Last modified:October 1, 2003 - v1
Checksum:i824408645AC8D0B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569695 Genomic DNA. Translation: CAE08785.1.
RefSeqiNP_898359.1. NC_005070.1.
WP_011129123.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08785; CAE08785; SYNW2270.
GeneIDi1730012.
KEGGisyw:SYNW2270.
PATRICi23836290. VBISynSp27240_2415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569695 Genomic DNA. Translation: CAE08785.1 .
RefSeqi NP_898359.1. NC_005070.1.
WP_011129123.1. NC_005070.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW2270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08785 ; CAE08785 ; SYNW2270 .
GeneIDi 1730012.
KEGGi syw:SYNW2270.
PATRICi 23836290. VBISynSp27240_2415.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiNADK2_SYNPX
AccessioniPrimary (citable) accession number: Q7U406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi