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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykF)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei155SubstrateUniRule annotation1
Binding sitei206ATPUniRule annotation1
Binding sitei297ATP; via carbonyl oxygenUniRule annotation1
Binding sitei328ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 360ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:SYNW2329
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460231 – 402Phosphoglycerate kinaseAdd BLAST402

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi84588.SYNW2329

Structurei

3D structure databases

ProteinModelPortaliQ7U3V0
SMRiQ7U3V0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni63 – 66Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.12603 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7U3V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRSLASLN AGDLSGKRVL VRVDFNVPLN EAGAITDDTR IRAALPTIND
60 70 80 90 100
LIGKGAKVIL SAHFGRPKGQ VNDAMRLTPV AARLSELLGK PVAKTDSCIG
110 120 130 140 150
PDAEAKVNAM ADGDVVLLEN VRFFAEEEKN DAGFAEKLAG LAEVYVNDAF
160 170 180 190 200
GAAHRAHAST EGVTKFLKPA VAGFLMEKEL QYLQGAVDEP KRPLAAIVGG
210 220 230 240 250
SKVSSKIGVL EALIDKCDKV LIGGGMIFTF YKARGLSVGK SLVEEDKLEL
260 270 280 290 300
AKELEAKAKA KGVELLLPTD VVLADNFAPD ANSQVADVTA IPDGWMGLDI
310 320 330 340 350
GPDAVKVFQD ALGDCQTVIW NGPMGVFEFE KFATGTNAIA TTLAELSGKG
360 370 380 390 400
CCTIIGGGDS VAAVEKAGLA DKMSHISTGG GASLELLEGK VLPGVAALND

AA
Length:402
Mass (Da):41,785
Last modified:October 1, 2003 - v1
Checksum:i478E8905AB3E90FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569695 Genomic DNA Translation: CAE08844.1
RefSeqiWP_011129182.1, NC_005070.1

Genome annotation databases

EnsemblBacteriaiCAE08844; CAE08844; SYNW2329
KEGGisyw:SYNW2329

Similar proteinsi

Entry informationi

Entry nameiPGK_SYNPX
AccessioniPrimary (citable) accession number: Q7U3V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome