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Q7U3S0

- SPEA_SYNPX

UniProt

Q7U3S0 - SPEA_SYNPX

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:SYNW2359
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Biosynthetic arginine decarboxylasePRO_0000149980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW2359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U3S0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni287 – 29711Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7U3S0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVADSEGWS IQDSAALYGL DRWGEPYFTI NGRGHISVQP QGERGGSLDL    50
    VELVSELRGR NLGLPLLIRF DDILEDRLER LHAAFERAIA QYSYTGRYQG 100
    VFPVKCNQQR HVVEELVICG KRWNFGLEAG SKAELLIALS LLDDPEALLI 150
    CNGYKDRLYI ETAILARRLG RQPVVVIEQP DEVDRIIEAS KSLGAAPYIG 200
    VRAKLSSRST GRWGSSVGDK AKFGLSIPEL LATVERLRES NLLPDLRLLH 250
    FHIGSQINDI AVLKDALQEA GQIYVELTRL GAPMGFLDVG GGLGIDYDGS 300
    RTASAASTNY SLQNYANDVV ATVRECCEPN AVAVPTLVSE SGRAIASHFS 350
    LLVFDVLGSS ALSASIPNAS GDEPLTVRNL RDTLVTIQEL SGTADAQLVR 400
    LQEAWNDALK FKQDALAAFR LGYMGLPDRA SAEQLTWACA DAIAQRLPKE 450
    QAIPEELAAL SKALAGTYYA NLSIFRSAPD TWAIDQLFPV VPIQKLNQRP 500
    TRLANLADLT CDSDGRLDRF IGDGQPKQLL ELHELDDNNP YLIGLFLSGA 550
    YQEVMGNLHN LFGTTNAVHI RLSPGGSYRI DHVVRGDTNA DVLEAMEHDP 600
    RVLLERLRVA AEAAINDGQL RIDESRRLLD HLESSLRQTT YLQD 644
    Length:644
    Mass (Da):70,760
    Last modified:October 1, 2003 - v1
    Checksum:iFAAF6AE897BA61EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569695 Genomic DNA. Translation: CAE08874.1.
    RefSeqiNP_898448.1. NC_005070.1.
    WP_011129212.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE08874; CAE08874; SYNW2359.
    GeneIDi1730904.
    KEGGisyw:SYNW2359.
    PATRICi23836480. VBISynSp27240_2510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569695 Genomic DNA. Translation: CAE08874.1 .
    RefSeqi NP_898448.1. NC_005070.1.
    WP_011129212.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U3S0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW2359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE08874 ; CAE08874 ; SYNW2359 .
    GeneIDi 1730904.
    KEGGi syw:SYNW2359.
    PATRICi 23836480. VBISynSp27240_2510.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiSPEA_SYNPX
    AccessioniPrimary (citable) accession number: Q7U3S0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3