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Q7U3Q5

- GCSP_SYNPX

UniProt

Q7U3Q5 - GCSP_SYNPX

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:SYNW2374
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_0000166941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi84588.SYNW2374.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U3Q5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U3Q5-1 [UniParc]FASTAAdd to Basket

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    MTSPFLQRHV GPSDSEQQQM LSALGYADMA AFLADVVPED ILDEFPPQGL    50
    LPPGCGEAEA LVHLREIAAA NNSRRSLIGL GYYGTSTPAL IQRHVFENPA 100
    WYTAYTPYQA EIAQGRLEAL LNFQTLISEL TGLPIANASL LDEATAAAEA 150
    MSLSYGICRR TEANRFLVDA NVLPQTWAVL QTRAEPLGID LERVTPEQAS 200
    FDASVFGVLL QLPGADGQIW DPTAVIARAH EAGALVTVAI DPLAQALIAP 250
    VASFGADIAV GSAQRFGVPM GFGGPHAAFF ATKDTYKRQI PGRLVGQSRD 300
    SAGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVMASF YAVHHGPEGL 350
    MSIARRIVGQ RRQLERALQS LGFVVPDGER FDTVTVTSAL APAVHQAVGE 400
    AGFNLRVLPD GANPAESTGF GIALDECTTA DELSRLVAAL ATAAGQTSPS 450
    LPLAPVEELC GVPERVDPWL SQSVFHDHLS ETELMRYIQR LVSRDLSLVH 500
    GMIPLGSCTM KLNAAAELLP VSWPAFAGLH PFAPMAQAAG YQRLAEQLEA 550
    WLAALTGFAA VSLQPNAGSQ GEYAGLLVIR AWHRSRGDDH RDVCLIPTSA 600
    HGTNPASAVM AGLKVVAVAC DADGNIDQQD LAARAAEHAD RLAALMVTYP 650
    STHGVFETGI RGICELVHRH GGQVYLDGAN LNAQVGLCRP GAFGADVCHL 700
    NLHKTFCIPH GGGGPGVGPI GVADHLAPFL PGHPMQASPD QAIGPVSAAA 750
    LGSASILPIS WMYLRMMGAE ALRQATAVAL LSANYLALRL DPHYPVLFRG 800
    ATGRVAHECI LDLRPLKRDA GIDVDDIAKR LMDYGFHAPT VSWPVAGTVM 850
    VEPTESESLA ELDRFADAMI AIRNEIRDIE SGAMDASNNP LKQAPHTMAA 900
    VIAEDWDRPY SRQQAAFPLP DQQQNKVWPA VARIDNAYGD RNLICTCPSV 950
    EEIAVAVAA 959
    Length:959
    Mass (Da):102,194
    Last modified:October 1, 2003 - v1
    Checksum:i504C96688933F957
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569695 Genomic DNA. Translation: CAE08889.1.
    RefSeqiNP_898463.1. NC_005070.1.
    WP_011129227.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE08889; CAE08889; SYNW2374.
    GeneIDi1730988.
    KEGGisyw:SYNW2374.
    PATRICi23836514. VBISynSp27240_2527.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569695 Genomic DNA. Translation: CAE08889.1 .
    RefSeqi NP_898463.1. NC_005070.1.
    WP_011129227.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U3Q5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW2374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE08889 ; CAE08889 ; SYNW2374 .
    GeneIDi 1730988.
    KEGGi syw:SYNW2374.
    PATRICi 23836514. VBISynSp27240_2527.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiGCSP_SYNPX
    AccessioniPrimary (citable) accession number: Q7U3Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3