Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7U3Q5

- GCSP_SYNPX

UniProt

Q7U3Q5 - GCSP_SYNPX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SYNW2374
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_0000166941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi84588.SYNW2374.

Structurei

3D structure databases

ProteinModelPortaliQ7U3Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U3Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSPFLQRHV GPSDSEQQQM LSALGYADMA AFLADVVPED ILDEFPPQGL
60 70 80 90 100
LPPGCGEAEA LVHLREIAAA NNSRRSLIGL GYYGTSTPAL IQRHVFENPA
110 120 130 140 150
WYTAYTPYQA EIAQGRLEAL LNFQTLISEL TGLPIANASL LDEATAAAEA
160 170 180 190 200
MSLSYGICRR TEANRFLVDA NVLPQTWAVL QTRAEPLGID LERVTPEQAS
210 220 230 240 250
FDASVFGVLL QLPGADGQIW DPTAVIARAH EAGALVTVAI DPLAQALIAP
260 270 280 290 300
VASFGADIAV GSAQRFGVPM GFGGPHAAFF ATKDTYKRQI PGRLVGQSRD
310 320 330 340 350
SAGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVMASF YAVHHGPEGL
360 370 380 390 400
MSIARRIVGQ RRQLERALQS LGFVVPDGER FDTVTVTSAL APAVHQAVGE
410 420 430 440 450
AGFNLRVLPD GANPAESTGF GIALDECTTA DELSRLVAAL ATAAGQTSPS
460 470 480 490 500
LPLAPVEELC GVPERVDPWL SQSVFHDHLS ETELMRYIQR LVSRDLSLVH
510 520 530 540 550
GMIPLGSCTM KLNAAAELLP VSWPAFAGLH PFAPMAQAAG YQRLAEQLEA
560 570 580 590 600
WLAALTGFAA VSLQPNAGSQ GEYAGLLVIR AWHRSRGDDH RDVCLIPTSA
610 620 630 640 650
HGTNPASAVM AGLKVVAVAC DADGNIDQQD LAARAAEHAD RLAALMVTYP
660 670 680 690 700
STHGVFETGI RGICELVHRH GGQVYLDGAN LNAQVGLCRP GAFGADVCHL
710 720 730 740 750
NLHKTFCIPH GGGGPGVGPI GVADHLAPFL PGHPMQASPD QAIGPVSAAA
760 770 780 790 800
LGSASILPIS WMYLRMMGAE ALRQATAVAL LSANYLALRL DPHYPVLFRG
810 820 830 840 850
ATGRVAHECI LDLRPLKRDA GIDVDDIAKR LMDYGFHAPT VSWPVAGTVM
860 870 880 890 900
VEPTESESLA ELDRFADAMI AIRNEIRDIE SGAMDASNNP LKQAPHTMAA
910 920 930 940 950
VIAEDWDRPY SRQQAAFPLP DQQQNKVWPA VARIDNAYGD RNLICTCPSV

EEIAVAVAA
Length:959
Mass (Da):102,194
Last modified:October 1, 2003 - v1
Checksum:i504C96688933F957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569695 Genomic DNA. Translation: CAE08889.1.
RefSeqiNP_898463.1. NC_005070.1.
WP_011129227.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE08889; CAE08889; SYNW2374.
GeneIDi1730988.
KEGGisyw:SYNW2374.
PATRICi23836514. VBISynSp27240_2527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569695 Genomic DNA. Translation: CAE08889.1 .
RefSeqi NP_898463.1. NC_005070.1.
WP_011129227.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U3Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW2374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE08889 ; CAE08889 ; SYNW2374 .
GeneIDi 1730988.
KEGGi syw:SYNW2374.
PATRICi 23836514. VBISynSp27240_2527.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiGCSP_SYNPX
AccessioniPrimary (citable) accession number: Q7U3Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3