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Q7U311 (Q7U311_MYCBO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAD92868.1
Ordered Locus Names:Mb0006
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q7U311 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 4D2A88F712E277EB

FASTA83892,301
        10         20         30         40         50         60 
MTDTTLPPDD SLDRIEPVDI QQEMQRSYID YAMSVIVGRA LPEVRDGLKP VHRRVLYAMF 

        70         80         90        100        110        120 
DSGFRPDRSH AKSARSVAET MGNYHPHGDA SIYDTLVRMA QPWSLRYPLV DGQGNFGSPG 

       130        140        150        160        170        180 
NDPPAAMRYT EARLTPLAME MLREIDEETV DFIPNYDGRV QEPTVLPSRF PNLLANGSGG 

       190        200        210        220        230        240 
IAVGMATNIP PHNLRELADA VFWALENHDA DEEETLAAVM GRVKGPDFPT AGLIVGSQGT 

       250        260        270        280        290        300 
ADAYKTGRGS IRMRGVVEVE EDSRGRTSLV ITELPYQVNH DNFITSIAEQ VRDGKLAGIS 

       310        320        330        340        350        360 
NIEDQSSDRV GLRIVIEIKR DAVAKVVINN LYKHTQLQTS FGANMLAIVD GVPRTLRLDQ 

       370        380        390        400        410        420 
LIRYYVDHQL DVIVRRTTYR LRKANERAHI LRGLVKALDA LDEVIALIRA SETVDIARAG 

       430        440        450        460        470        480 
LIELLDIDEI QAQAILDMQL RRLAALERQR IIDDLAKIEA EIADLEDILA KPERQRGIVR 

       490        500        510        520        530        540 
DELAEIVDRH GDDRRTRIIA ADGDVSDEDL IAREDVVVTI TETGYAKRTK TDLYRSQKRG 

       550        560        570        580        590        600 
GKGVQGAGLK QDDIVAHFFV CSTHDLILFF TTQGRVYRAK AYDLPEASRT ARGQHVANLL 

       610        620        630        640        650        660 
AFQPEERIAQ VIQIRGYTDA PYLVLATRNG LVKKSKLTAF DSNRSGGIVA VNLRDNDELV 

       670        680        690        700        710        720 
GAVLCSADDD LLLVSANGQS IRFSATDEAL RPMGRATSGV QGMRFNIDDR LLSLNVVREG 

       730        740        750        760        770        780 
TYLLVATSGG YAKRTAIEEY PVQGRGGKGV LTVMYDRRRG RLVGALIVDD DSELYAVTSG 

       790        800        810        820        830 
GGVIRTAARQ VRKAGRQTKG VRLMNLGEGD TLLAIARNAE ESGDDNAVDA NGADQTGN

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248334 Genomic DNA. Translation: CAD92868.1.
RefSeqNP_853676.1. NC_002945.3.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortalQ7U311.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000015403; EBMYCP00000015238; EBMYCG00000015400.
GeneID1090748.
GenomeReviewsGene locus Mb0006 in contig BX248333_GR.
KEGGmbo:Mb0006.
PATRIC18001669. VBIMycBov88188_0006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016653.
HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ7U311_MYCBO
AccessionPrimary (citable) accession number: Q7U311
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info