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Q7U2I0 (GABD1_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate-semialdehyde dehydrogenase [NADP+] 1
Short name=SSADH 1
Short name=SSDH 1
EC=1.2.1.16
Gene names
Name:gabD1
Ordered Locus Names:Mb0239c
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.

Catalytic activity

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence caution

The sequence CAD93103.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinate-semialdehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Succinate-semialdehyde dehydrogenase [NADP+] 1
PRO_0000310701

Regions

Nucleotide binding209 – 2146NAD or NADP By similarity
Compositional bias19 – 11799Ala-rich

Sites

Active site2311 By similarity
Active site2651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U2I0 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: B391266C5441A05F

FASTA45748,545
        10         20         30         40         50         60 
MPIATINPAT GETVKTFTAA TDDEVDAAIA RAHRRFADYR QTSFAQRARW ANATADLLEA 

        70         80         90        100        110        120 
EADQAAAMMT LEMGKTLAAA KAEALKCAKG FRYYAENAEA LLADEPADAA KVGASAAYGR 

       130        140        150        160        170        180 
YQPLGVILAV MPWNFPLWQA VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPD 

       190        200        210        220        230        240 
GCFQTLLVSS GAVEAILRDP RVAAATLTGS EPAGQSVGAI AGNEIKPTVL ELGGSDPFIV 

       250        260        270        280        290        300 
MPSADLDAAV STAVTGRVQN NGQSCIAAKR FIVHADIYDD FVDKFVARMA ALRVGDPTDP 

       310        320        330        340        350        360 
DTDVGPLATE QGRNEVAKQV EDAAAAGAVI RCGGKRLDRP GWFYPPTVIT DISKDMALYT 

       370        380        390        400        410        420 
EEVFGPVASV FRAANIDEAV EIANATTFGL GSNAWTRDET EQRRFIDDIV AGQVFINGMT 

       430        440        450 
VSYPELPFGG VKRSGYGREL SAHGIREFCN IKTVWIA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248334 Genomic DNA. Translation: CAD93103.1. Different initiation.
RefSeqNP_853904.1. NC_002945.3.

3D structure databases

HSSPHSSP built from PDB template 1ZUM based on UniProtKB P05091.
ProteinModelPortalQ7U2I0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000016989; EBMYCP00000016824; EBMYCG00000016984.
GeneID1090988.
GenomeReviewsGene locus Mb0239c in contig BX248333_GR.
KEGGmbo:Mb0239c.
PATRIC18002194. VBIMycBov88188_0266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015659.
HOGENOMHBG752218.
ProtClustDBPRK09406.

Enzyme and pathway databases

BioCycMBOV233413:MB0239C-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD1_MYCBO
AccessionPrimary (citable) accession number: Q7U2I0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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