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Q7U1J9

- MMAA2_MYCBO

UniProt

Q7U1J9 - MMAA2_MYCBO

Protein

Cyclopropane mycolic acid synthase MmaA2

Gene

cmaC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
    Active sitei269 – 2691By similarity

    GO - Molecular functioni

    1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC
    2. methyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. mycolic acid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00915.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclopropane mycolic acid synthase MmaA2 (EC:2.1.1.79)
    Short name:
    CMAS
    Alternative name(s):
    Cyclopropane-fatty-acyl-phospholipid synthase
    Short name:
    CFA synthase
    Mycolic acid methyltransferase
    Short name:
    MA-MT
    S-adenosylmethionine-dependent methyltransferase
    Short name:
    AdoMet-MT
    Short name:
    SAM-MT
    Gene namesi
    Name:cmaC
    Synonyms:mmaA2, mmas-2
    Ordered Locus Names:Mb0663c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Cyclopropane mycolic acid synthase MmaA2PRO_0000398360Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb0663c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U1J9.
    SMRiQ7U1J9. Positions 3-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 342S-adenosyl-L-methionine bindingBy similarity
    Regioni72 – 743S-adenosyl-L-methionine bindingBy similarity
    Regioni94 – 996S-adenosyl-L-methionine bindingBy similarity
    Regioni123 – 1242S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the CFA/CMAS family.Curated

    Phylogenomic databases

    eggNOGiCOG2230.
    HOGENOMiHOG000245191.
    KOiK00574.
    OMAiKDRQYSC.
    OrthoDBiEOG6BGNZP.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02353. CMAS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003085. CMAS. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U1J9-1 [UniParc]FASTAAdd to Basket

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    MVNDLTPHFE DVQAHYDLSD DFFRLFLDPT QTYSCAHFER EDMTLEEAQI    50
    AKIDLALGKL GLQPGMTLLD IGCGWGATMR RAIAQYDVNV VGLTLSKNQA 100
    AHVQKSFDEM DTPLDRRVLL AGWEQFNEPV DRIVSIGAFE HFGHDRHADF 150
    FARAHKILPP DGVLLLHTIT GLTRQQMVDH GLPLTLWLAR FLKFIATEIF 200
    PGGQPPTIEM VEEQSAKTGF TLTRRQSLQP HYARTLDLWA EALQEHKSEA 250
    IAIQSEEVYE RYMKYLTGCA KLFRVGYIDV NQFTLAK 287
    Length:287
    Mass (Da):32,681
    Last modified:October 1, 2003 - v1
    Checksum:i4894FF920B090129
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081I → S in AAC44874. (PubMed:9044265)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77466 Genomic DNA. Translation: AAC44874.1.
    BX248333 Genomic DNA. Translation: CDO41907.1.
    RefSeqiNP_854321.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD93525; CAD93525; Mb0663c.
    GeneIDi1091773.
    KEGGimbo:Mb0663c.
    PATRICi18003118. VBIMycBov88188_0723.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77466 Genomic DNA. Translation: AAC44874.1 .
    BX248333 Genomic DNA. Translation: CDO41907.1 .
    RefSeqi NP_854321.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7U1J9.
    SMRi Q7U1J9. Positions 3-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb0663c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD93525 ; CAD93525 ; Mb0663c .
    GeneIDi 1091773.
    KEGGi mbo:Mb0663c.
    PATRICi 18003118. VBIMycBov88188_0723.

    Phylogenomic databases

    eggNOGi COG2230.
    HOGENOMi HOG000245191.
    KOi K00574.
    OMAi KDRQYSC.
    OrthoDBi EOG6BGNZP.

    Enzyme and pathway databases

    UniPathwayi UPA00915 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02353. CMAS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003085. CMAS. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto- and hydroxy-mycolic acids."
      Dubnau E., Laneelle M.-A., Soares S., Benichou A., Vaz T., Prome D., Prome J.-C., Daffe M., Quemard A.
      Mol. Microbiol. 23:313-322(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN OXYGEN-CONTAINING MYCOLATES BIOSYNTHESIS, NOMENCLATURE.
      Strain: BCG / Pasteur.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiMMAA2_MYCBO
    AccessioniPrimary (citable) accession number: Q7U1J9
    Secondary accession number(s): P94923, X2BFN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3