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Protein

Acyl-CoA dehydrogenase fadE12

Gene

fadE12

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase fadE12 (EC:1.3.99.-)
Gene namesi
Name:fadE12
Ordered Locus Names:Mb0997c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Acyl-CoA dehydrogenase fadE12PRO_0000201184Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7U0Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000131659.
OMAiKPCLFIV.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U0Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSFIESE ERQALRKAVA SWVANYGHEY YLDKARKHEH TSELWAEAGK
60 70 80 90 100
LGFLGVNLPE EYGGGGAGMY ELSLVMEEMA AAGSALLLMV VSPAINGTII
110 120 130 140 150
AKFGTDDQKK RWLPGIADGS LTMAFAITEP DAGSNSHKIT TTARRDGSDW
160 170 180 190 200
IIKGQKVFIS GIDQAQAVLV VGRSEEAKTG KLRPALFVVP TDAPGFSYTP
210 220 230 240 250
IEMELVSPER QFQVFLDDVR LPADALVGAE DAAIAHLFAG LNPERIMGAA
260 270 280 290 300
SAVGMGRFAL GRAVDYVKTR KVWSTPIGAH QGLAHPLAQC HIEVELAKLM
310 320 330 340 350
TQKAATLYDH GDDFGAAEAA NMAKYAAAEA SSRAVDQAVQ SMGGNGLTKE
360 370 380
YGVAAMMTSA RLARIAPISR EMVLNFVAQT SLGLPRSY
Length:388
Mass (Da):41,524
Last modified:October 1, 2003 - v1
Checksum:iA57E5AD6F1B74384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42242.1.
RefSeqiNP_854654.1. NC_002945.3.
WP_010950473.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42242; CDO42242; Mb0997c.
GeneIDi1093082.
KEGGimbo:Mb0997c.
PATRICi18003859. VBIMycBov88188_1086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42242.1.
RefSeqiNP_854654.1. NC_002945.3.
WP_010950473.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7U0Y2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42242; CDO42242; Mb0997c.
GeneIDi1093082.
KEGGimbo:Mb0997c.
PATRICi18003859. VBIMycBov88188_1086.

Phylogenomic databases

HOGENOMiHOG000131659.
OMAiKPCLFIV.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDC_MYCBO
AccessioniPrimary (citable) accession number: Q7U0Y2
Secondary accession number(s): X2BGF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Maximum activity is obtained with n-octanol-CoA.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.