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Q7U0E7 (DAPD_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:Mb1233c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA By similarity. HAMAP-Rule MF_02122

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_02122

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_02122

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_02122

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02122.

Sequence similarities

Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3173172,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_02122
PRO_0000412255

Regions

Region257 – 2582Succinyl-CoA binding By similarity
Region290 – 2934Succinyl-CoA binding By similarity

Sites

Active site1991Acyl-anhydride intermediate By similarity
Metal binding1661Magnesium 1; shared with trimeric partners By similarity
Metal binding1831Magnesium 2; shared with trimeric partners By similarity
Binding site2011Succinyl-CoA By similarity
Binding site2161Succinyl-CoA; via amide nitrogen By similarity
Binding site2191Succinyl-CoA By similarity
Binding site2421Succinyl-CoA; via amide nitrogen By similarity
Binding site2651Succinyl-CoA; via carbonyl oxygen By similarity
Binding site2771Succinyl-CoA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U0E7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EF204F46B90ADFF3

FASTA31732,642
        10         20         30         40         50         60 
MSTVTGAAGI GLATLAADGS VLDTWFPAPE LTESGTSATS RLAVSDVPVE LAALIGRDDD 

        70         80         90        100        110        120 
RRTETIAVRT VIGSLDDVAA DPYDAYLRLH LLSHRLVAPH GLNAGGLFGV LTNVVWTNHG 

       130        140        150        160        170        180 
PCAIDGFEAV RARLRRRGPV TVYGVDKFPR MVDYVVPTGV RIADADRVRL GAHLAPGTTV 

       190        200        210        220        230        240 
MHEGFVNYNA GTLGASMVEG RISAGVVVGD GSDVGGGASI MGTLSGGGTH VISIGKRCLL 

       250        260        270        280        290        300 
GANSGLGISL GDDCVVEAGL YVTAGTRVTM PDSNSVKARE LSGSSNLLFR RNSVSGAVEV 

       310 
LARDGQGIAL NEDLHAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248338 Genomic DNA. Translation: CAD94094.1.
RefSeqNP_854887.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7U0E7.
SMRQ7U0E7. Positions 3-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1233c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94094; CAD94094; Mb1233c.
GeneID1090520.
KEGGmbo:Mb1233c.
PATRIC18004399. VBIMycBov88188_1352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000248194.
KOK00674.
OMATVLDTWF.
OrthoDBEOG6HQSR3.
ProtClustDBCLSK791010.

Enzyme and pathway databases

UniPathwayUPA00034; UER00019.

Family and domain databases

HAMAPMF_02122. DapD_type2.
InterProIPR019875. DapD_actinobacteria.
IPR011004. Trimer_LpxA-like.
IPR026586. Type2_DapD.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR03535. DapD_actino. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPD_MYCBO
AccessionPrimary (citable) accession number: Q7U0E7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways