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Q7U0E7

- DAPD_MYCBO

UniProt

Q7U0E7 - DAPD_MYCBO

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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.UniRule annotation

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi166 – 1661Magnesium 1; shared with trimeric partnersUniRule annotation
Metal bindingi183 – 1831Magnesium 2; shared with trimeric partnersUniRule annotation
Active sitei199 – 1991Acyl-anhydride intermediateUniRule annotation
Binding sitei201 – 2011Succinyl-CoAUniRule annotation
Binding sitei216 – 2161Succinyl-CoA; via amide nitrogenUniRule annotation
Binding sitei219 – 2191Succinyl-CoAUniRule annotation
Binding sitei242 – 2421Succinyl-CoA; via amide nitrogenUniRule annotation
Binding sitei265 – 2651Succinyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei277 – 2771Succinyl-CoAUniRule annotation

GO - Molecular functioni

  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:Mb1233c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3173172,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_0000412255Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi233413.Mb1233c.

Structurei

3D structure databases

ProteinModelPortaliQ7U0E7.
SMRiQ7U0E7. Positions 3-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2582Succinyl-CoA bindingUniRule annotation
Regioni290 – 2934Succinyl-CoA bindingUniRule annotation

Sequence similaritiesi

Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248194.
KOiK00674.
OMAiTVLDTWF.
OrthoDBiEOG6HQSR3.

Family and domain databases

HAMAPiMF_02122. DapD_type2.
InterProiIPR019875. DapD_actinobacteria.
IPR011004. Trimer_LpxA-like.
IPR026586. Type2_DapD.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR03535. DapD_actino. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U0E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVTGAAGI GLATLAADGS VLDTWFPAPE LTESGTSATS RLAVSDVPVE
60 70 80 90 100
LAALIGRDDD RRTETIAVRT VIGSLDDVAA DPYDAYLRLH LLSHRLVAPH
110 120 130 140 150
GLNAGGLFGV LTNVVWTNHG PCAIDGFEAV RARLRRRGPV TVYGVDKFPR
160 170 180 190 200
MVDYVVPTGV RIADADRVRL GAHLAPGTTV MHEGFVNYNA GTLGASMVEG
210 220 230 240 250
RISAGVVVGD GSDVGGGASI MGTLSGGGTH VISIGKRCLL GANSGLGISL
260 270 280 290 300
GDDCVVEAGL YVTAGTRVTM PDSNSVKARE LSGSSNLLFR RNSVSGAVEV
310
LARDGQGIAL NEDLHAN
Length:317
Mass (Da):32,642
Last modified:October 1, 2003 - v1
Checksum:iEF204F46B90ADFF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42480.1.
RefSeqiNP_854887.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94094; CAD94094; Mb1233c.
GeneIDi1090520.
KEGGimbo:Mb1233c.
PATRICi18004399. VBIMycBov88188_1352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42480.1 .
RefSeqi NP_854887.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7U0E7.
SMRi Q7U0E7. Positions 3-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1233c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94094 ; CAD94094 ; Mb1233c .
GeneIDi 1090520.
KEGGi mbo:Mb1233c.
PATRICi 18004399. VBIMycBov88188_1352.

Phylogenomic databases

HOGENOMi HOG000248194.
KOi K00674.
OMAi TVLDTWF.
OrthoDBi EOG6HQSR3.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00019 .

Family and domain databases

HAMAPi MF_02122. DapD_type2.
InterProi IPR019875. DapD_actinobacteria.
IPR011004. Trimer_LpxA-like.
IPR026586. Type2_DapD.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR03535. DapD_actino. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiDAPD_MYCBO
AccessioniPrimary (citable) accession number: Q7U0E7
Secondary accession number(s): X2BHN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3