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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.UniRule annotation

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi166Magnesium 1; shared with trimeric partnersUniRule annotation1
Metal bindingi183Magnesium 2; shared with trimeric partnersUniRule annotation1
Active sitei199Acyl-anhydride intermediateUniRule annotation1
Binding sitei201Succinyl-CoAUniRule annotation1
Binding sitei216Succinyl-CoA; via amide nitrogenUniRule annotation1
Binding sitei219Succinyl-CoAUniRule annotation1
Binding sitei242Succinyl-CoA; via amide nitrogenUniRule annotation1
Binding sitei265Succinyl-CoA; via carbonyl oxygenUniRule annotation1
Binding sitei277Succinyl-CoAUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1281-MONOMER
UniPathwayiUPA00034; UER00019

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BQ2027_MB1233C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122551 – 3172,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseAdd BLAST317

Proteomic databases

PRIDEiQ7U0E7

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7U0E7
SMRiQ7U0E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 258Succinyl-CoA bindingUniRule annotation2
Regioni290 – 293Succinyl-CoA bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248194
OMAiTVLDTWF

Family and domain databases

Gene3Di3.30.60.701 hit
HAMAPiMF_02122 DapD_type2, 1 hit
InterProiView protein in InterPro
IPR019875 DapD_actinobacteria
IPR001451 Hexapep
IPR032784 THDPS_M
IPR038361 THDPS_M_sf
IPR011004 Trimer_LpxA-like_sf
IPR026586 Type2_DapD
PfamiView protein in Pfam
PF14602 Hexapep_2, 1 hit
PF14789 THDPS_M, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR03535 DapD_actino, 1 hit

Sequencei

Sequence statusi: Complete.

Q7U0E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVTGAAGI GLATLAADGS VLDTWFPAPE LTESGTSATS RLAVSDVPVE
60 70 80 90 100
LAALIGRDDD RRTETIAVRT VIGSLDDVAA DPYDAYLRLH LLSHRLVAPH
110 120 130 140 150
GLNAGGLFGV LTNVVWTNHG PCAIDGFEAV RARLRRRGPV TVYGVDKFPR
160 170 180 190 200
MVDYVVPTGV RIADADRVRL GAHLAPGTTV MHEGFVNYNA GTLGASMVEG
210 220 230 240 250
RISAGVVVGD GSDVGGGASI MGTLSGGGTH VISIGKRCLL GANSGLGISL
260 270 280 290 300
GDDCVVEAGL YVTAGTRVTM PDSNSVKARE LSGSSNLLFR RNSVSGAVEV
310
LARDGQGIAL NEDLHAN
Length:317
Mass (Da):32,642
Last modified:October 1, 2003 - v1
Checksum:iEF204F46B90ADFF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIT99834.1
RefSeqiNP_854887.1, NC_002945.3
WP_003898768.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42480; CDO42480; Mb1233c
PATRICifig|233413.5.peg.1352

Similar proteinsi

Entry informationi

Entry nameiDAPD_MYCBO
AccessioniPrimary (citable) accession number: Q7U0E7
Secondary accession number(s): A0A1R3XXP4, X2BHN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome