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Protein

Serine/threonine-protein kinase PknH

Gene

pknH

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknH (EC:2.7.11.1)
Gene namesi
Name:pknH
Ordered Locus Names:Mb1297c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 373CytoplasmicSequence analysisAdd BLAST373
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 596ExtracellularSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712171 – 596Serine/threonine-protein kinase PknHAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphothreonineBy similarity1

Post-translational modificationi

Autophosphorylated on threonine and serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7U095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST261

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi306 – 373Pro-richAdd BLAST68

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000050426.
KOiK08884.
OMAiLANCPGE.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAQDSRVG SMFGPYHLKR LLGRGGMGEV YEAEHTVKEW TVAVKLMTAE
60 70 80 90 100
FSKDPVFRER MKREARIAGR LQEPHVVPIH DYGEVDGQMF LEMRLVEGTD
110 120 130 140 150
LDSVLKRFGP LTPPRAVAII TQIASALDAA HADGVMHRDV KPQNILITRD
160 170 180 190 200
DFAYLVDFGI ASATTDEKLT QLGTAVGTWK YMAPERFSND EVTYRADIYA
210 220 230 240 250
LACVLHECLT GAPPYRADSA GTLVSSHLMG PIPQPSAIRP GIPKAFDAVV
260 270 280 290 300
ARGMAKKPED RYASAGDLAL AAHEALSDPD QDHAADILRR SQESTLPGTA
310 320 330 340 350
AVTAQPPTMP TVTPPPIQAA PTGQPSWAPN SGPMPASGPT PTPQYYQGGG
360 370 380 390 400
WGAPPSGGPS PWAQTPRKTN PWPLVAGAAA VVLVLVLGAI GIWIANRPKP
410 420 430 440 450
VQPPQPVAEE RLSALLLNSS EVNAVMGSSS MQPGKPITSM DSSPVTVSLP
460 470 480 490 500
DCQGALYTSQ DPVYAGTGYT AINGLISSEP GDNYEHWVNQ AVVAFPTADK
510 520 530 540 550
ARAFVQTSAD KWKNCAGKTV TVTNKAKTYR WTFADVKGSP PTITVIDTQE
560 570 580 590
GAEGWECQRA MSVANNVVVD VNACGYQITN QAGQIAAKIV DKVNKE
Length:596
Mass (Da):63,697
Last modified:October 1, 2003 - v1
Checksum:i5E335EF65DD53D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqiNP_854951.1. NC_002945.3.
WP_010950514.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42544; CDO42544; Mb1297c.
GeneIDi1090581.
KEGGimbo:Mb1297c.
PATRICi18004539. VBIMycBov88188_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqiNP_854951.1. NC_002945.3.
WP_010950514.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7U095.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42544; CDO42544; Mb1297c.
GeneIDi1090581.
KEGGimbo:Mb1297c.
PATRICi18004539. VBIMycBov88188_1422.

Phylogenomic databases

HOGENOMiHOG000050426.
KOiK08884.
OMAiLANCPGE.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNH_MYCBO
AccessioniPrimary (citable) accession number: Q7U095
Secondary accession number(s): X2BH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.