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Q7U095 (PKNH_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknH

EC=2.7.11.1
Gene names
Name:pknH
Ordered Locus Names:Mb1297c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Post-translational modification

Autophosphorylated on threonine and serine residues By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Serine/threonine-protein kinase PknH
PRO_0000171217

Regions

Topological domain1 – 373373Cytoplasmic Potential
Transmembrane374 – 39421Helical; Potential
Topological domain395 – 596202Extracellular Potential
Domain16 – 276261Protein kinase
Nucleotide binding22 – 309ATP By similarity
Compositional bias306 – 37368Pro-rich

Sites

Active site1391Proton acceptor By similarity
Binding site451ATP By similarity

Amino acid modifications

Modified residue1701Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7U095 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5E335EF65DD53D97

FASTA59663,697
        10         20         30         40         50         60 
MSDAQDSRVG SMFGPYHLKR LLGRGGMGEV YEAEHTVKEW TVAVKLMTAE FSKDPVFRER 

        70         80         90        100        110        120 
MKREARIAGR LQEPHVVPIH DYGEVDGQMF LEMRLVEGTD LDSVLKRFGP LTPPRAVAII 

       130        140        150        160        170        180 
TQIASALDAA HADGVMHRDV KPQNILITRD DFAYLVDFGI ASATTDEKLT QLGTAVGTWK 

       190        200        210        220        230        240 
YMAPERFSND EVTYRADIYA LACVLHECLT GAPPYRADSA GTLVSSHLMG PIPQPSAIRP 

       250        260        270        280        290        300 
GIPKAFDAVV ARGMAKKPED RYASAGDLAL AAHEALSDPD QDHAADILRR SQESTLPGTA 

       310        320        330        340        350        360 
AVTAQPPTMP TVTPPPIQAA PTGQPSWAPN SGPMPASGPT PTPQYYQGGG WGAPPSGGPS 

       370        380        390        400        410        420 
PWAQTPRKTN PWPLVAGAAA VVLVLVLGAI GIWIANRPKP VQPPQPVAEE RLSALLLNSS 

       430        440        450        460        470        480 
EVNAVMGSSS MQPGKPITSM DSSPVTVSLP DCQGALYTSQ DPVYAGTGYT AINGLISSEP 

       490        500        510        520        530        540 
GDNYEHWVNQ AVVAFPTADK ARAFVQTSAD KWKNCAGKTV TVTNKAKTYR WTFADVKGSP 

       550        560        570        580        590 
PTITVIDTQE GAEGWECQRA MSVANNVVVD VNACGYQITN QAGQIAAKIV DKVNKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqNP_854951.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7U095.
SMRQ7U095. Positions 14-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1297c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94158; CAD94158; Mb1297c.
GeneID1090581.
KEGGmbo:Mb1297c.
PATRIC18004539. VBIMycBov88188_1422.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000050426.
KOK08884.
OMAAPERFAN.
OrthoDBEOG6B35XT.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNH_MYCBO
AccessionPrimary (citable) accession number: Q7U095
Secondary accession number(s): X2BH99
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families