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Protein

Serine/threonine-protein kinase PknH

Gene

pknH

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknH (EC:2.7.11.1)
Gene namesi
Name:pknH
Ordered Locus Names:Mb1297c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 373373CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence AnalysisAdd
BLAST
Topological domaini395 – 596202ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Serine/threonine-protein kinase PknHPRO_0000171217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei170 – 1701PhosphothreonineBy similarity

Post-translational modificationi

Autophosphorylated on threonine and serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1297c.

Structurei

3D structure databases

ProteinModelPortaliQ7U095.
SMRiQ7U095. Positions 14-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 276261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi306 – 37368Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000050426.
KOiK08884.
OMAiAPERFAN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAQDSRVG SMFGPYHLKR LLGRGGMGEV YEAEHTVKEW TVAVKLMTAE
60 70 80 90 100
FSKDPVFRER MKREARIAGR LQEPHVVPIH DYGEVDGQMF LEMRLVEGTD
110 120 130 140 150
LDSVLKRFGP LTPPRAVAII TQIASALDAA HADGVMHRDV KPQNILITRD
160 170 180 190 200
DFAYLVDFGI ASATTDEKLT QLGTAVGTWK YMAPERFSND EVTYRADIYA
210 220 230 240 250
LACVLHECLT GAPPYRADSA GTLVSSHLMG PIPQPSAIRP GIPKAFDAVV
260 270 280 290 300
ARGMAKKPED RYASAGDLAL AAHEALSDPD QDHAADILRR SQESTLPGTA
310 320 330 340 350
AVTAQPPTMP TVTPPPIQAA PTGQPSWAPN SGPMPASGPT PTPQYYQGGG
360 370 380 390 400
WGAPPSGGPS PWAQTPRKTN PWPLVAGAAA VVLVLVLGAI GIWIANRPKP
410 420 430 440 450
VQPPQPVAEE RLSALLLNSS EVNAVMGSSS MQPGKPITSM DSSPVTVSLP
460 470 480 490 500
DCQGALYTSQ DPVYAGTGYT AINGLISSEP GDNYEHWVNQ AVVAFPTADK
510 520 530 540 550
ARAFVQTSAD KWKNCAGKTV TVTNKAKTYR WTFADVKGSP PTITVIDTQE
560 570 580 590
GAEGWECQRA MSVANNVVVD VNACGYQITN QAGQIAAKIV DKVNKE
Length:596
Mass (Da):63,697
Last modified:October 1, 2003 - v1
Checksum:i5E335EF65DD53D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqiNP_854951.1. NC_002945.3.
WP_010950514.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42544; CDO42544; Mb1297c.
GeneIDi1090581.
KEGGimbo:Mb1297c.
PATRICi18004539. VBIMycBov88188_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqiNP_854951.1. NC_002945.3.
WP_010950514.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7U095.
SMRiQ7U095. Positions 14-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233413.Mb1297c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42544; CDO42544; Mb1297c.
GeneIDi1090581.
KEGGimbo:Mb1297c.
PATRICi18004539. VBIMycBov88188_1422.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000050426.
KOiK08884.
OMAiAPERFAN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNH_MYCBO
AccessioniPrimary (citable) accession number: Q7U095
Secondary accession number(s): X2BH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.