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Q7U095

- PKNH_MYCBO

UniProt

Q7U095 - PKNH_MYCBO

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Protein
Serine/threonine-protein kinase PknH
Gene
pknH, Mb1297c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATP By similarity
Active sitei139 – 1391Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknH (EC:2.7.11.1)
Gene namesi
Name:pknH
Ordered Locus Names:Mb1297c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 373373Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei374 – 39421Helical; Reviewed prediction
Add
BLAST
Topological domaini395 – 596202Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Serine/threonine-protein kinase PknH
PRO_0000171217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei170 – 1701Phosphothreonine By similarity

Post-translational modificationi

Autophosphorylated on threonine and serine residues By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1297c.

Structurei

3D structure databases

ProteinModelPortaliQ7U095.
SMRiQ7U095. Positions 14-269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 276261Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi306 – 37368Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000050426.
KOiK08884.
OMAiAPERFAN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U095-1 [UniParc]FASTAAdd to Basket

« Hide

MSDAQDSRVG SMFGPYHLKR LLGRGGMGEV YEAEHTVKEW TVAVKLMTAE    50
FSKDPVFRER MKREARIAGR LQEPHVVPIH DYGEVDGQMF LEMRLVEGTD 100
LDSVLKRFGP LTPPRAVAII TQIASALDAA HADGVMHRDV KPQNILITRD 150
DFAYLVDFGI ASATTDEKLT QLGTAVGTWK YMAPERFSND EVTYRADIYA 200
LACVLHECLT GAPPYRADSA GTLVSSHLMG PIPQPSAIRP GIPKAFDAVV 250
ARGMAKKPED RYASAGDLAL AAHEALSDPD QDHAADILRR SQESTLPGTA 300
AVTAQPPTMP TVTPPPIQAA PTGQPSWAPN SGPMPASGPT PTPQYYQGGG 350
WGAPPSGGPS PWAQTPRKTN PWPLVAGAAA VVLVLVLGAI GIWIANRPKP 400
VQPPQPVAEE RLSALLLNSS EVNAVMGSSS MQPGKPITSM DSSPVTVSLP 450
DCQGALYTSQ DPVYAGTGYT AINGLISSEP GDNYEHWVNQ AVVAFPTADK 500
ARAFVQTSAD KWKNCAGKTV TVTNKAKTYR WTFADVKGSP PTITVIDTQE 550
GAEGWECQRA MSVANNVVVD VNACGYQITN QAGQIAAKIV DKVNKE 596
Length:596
Mass (Da):63,697
Last modified:October 1, 2003 - v1
Checksum:i5E335EF65DD53D97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1.
RefSeqiNP_854951.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94158; CAD94158; Mb1297c.
GeneIDi1090581.
KEGGimbo:Mb1297c.
PATRICi18004539. VBIMycBov88188_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42544.1 .
RefSeqi NP_854951.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7U095.
SMRi Q7U095. Positions 14-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1297c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94158 ; CAD94158 ; Mb1297c .
GeneIDi 1090581.
KEGGi mbo:Mb1297c.
PATRICi 18004539. VBIMycBov88188_1422.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000050426.
KOi K08884.
OMAi APERFAN.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNH_MYCBO
AccessioniPrimary (citable) accession number: Q7U095
Secondary accession number(s): X2BH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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