Q7U004 (ECH12_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable enoyl-CoA hydratase echA12
EC=4.2.1.17

Gene names

Name:	echA12
Ordered Locus Names:	Mb1507

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could possibly oxidize fatty acids using specific components By similarity.
Catalytic activity	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-CoA hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Probable enoyl-CoA hydratase echA12		PRO_0000109339

Sequences

	Sequence		Length	Mass (Da)
	Q7U004 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 498D32EB8BD8DD70	FASTA	285	30,565
	10 20 30 40 50 60 MPHRCAAQVV AGYRSTVSLV LVEHPRPEIA QITLNRPERM NSMAFDVMVP LKEALAQVSY 70 80 90 100 110 120 DNSVRVVVLT GAGRGFSSGA DHKSAGVVPH VENLTRPTYA LRSMELLDDV ILMLRRLHQP 130 140 150 160 170 180 VIAAVNGPAI GGGLCLALAA DIRVASSSAY FRAAGINNGL TASELGLSYL LPRAIGSSRA 190 200 210 220 230 240 FEIMLTGRDV SAEEAERIGL VSRQVPDEQL LDACYAIAAR MAGFSRPGIE LTKRTLWSGL 250 260 270 280 DAASLEAHMQ AEGLGQLFVR LLTANFEEAV AARAEQRAPV FTDDT

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248339 Genomic DNA. Translation: CAD96174.1.
RefSeq	NP_855159.1. NC_002945.3.
3D structure databases
ProteinModelPortal	Q7U004.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000017187; EBMYCP00000017022; EBMYCG00000017182.
GeneID	1092364.
GenomeReviews	Gene locus Mb1507 in contig BX248333_GR.
KEGG	mbo:Mb1507.
PATRIC	18005002. VBIMycBov88188_1648.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015506.
HOGENOM	HBG748731.
OMA	LEGHMQA.
ProtClustDB	PRK05864.
Enzyme and pathway databases
BioCyc	MBOV233413:MB1507-MONOMER.
Family and domain databases
InterPro	IPR001753. Crotonase_core. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
KO	K01692.
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECH12_MYCBO

Accession

Primary (citable) accession number: Q7U004

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program