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Q7TZN3 (PKNE_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknE

EC=2.7.11.1
Gene names
Name:pknE
Ordered Locus Names:Mb1772
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Post-translational modification

Autophosphorylated on serine and threonine residues. Dephosphorylated by PstP By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Serine/threonine-protein kinase PknE
PRO_0000171210

Regions

Topological domain1 – 337337Cytoplasmic Potential
Transmembrane338 – 35821Helical; Potential
Topological domain359 – 566208Extracellular Potential
Domain16 – 275260Protein kinase
Nucleotide binding22 – 309ATP By similarity

Sites

Active site1391Proton acceptor By similarity
Binding site451ATP By similarity

Amino acid modifications

Modified residue71Phosphoserine; by autocatalysis By similarity
Modified residue111Phosphothreonine; by autocatalysis By similarity
Modified residue501Phosphothreonine; by autocatalysis By similarity
Modified residue591Phosphothreonine; by autocatalysis By similarity
Modified residue1701Phosphothreonine; by autocatalysis By similarity
Modified residue1751Phosphothreonine; by autocatalysis By similarity
Modified residue1781Phosphothreonine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TZN3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 6F7534068DE608A4

FASTA56660,528
        10         20         30         40         50         60 
MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET LSSDPDFRTR 

        70         80         90        100        110        120 
MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD LAAMLRRQGP LAPPRAVAIV 

       130        140        150        160        170        180 
RQIGSALDAA HAAGATHRDV KPENILVSAD DFAYLVDFGI ASATTDEKLT QLGNTVGTLY 

       190        200        210        220        230        240 
YMAPERFSES HATYRADIYA LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG 

       250        260        270        280        290        300 
IPVAFDAVIA RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST 

       310        320        330        340        350        360 
HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL AGGLGIALAH 

       370        380        390        400        410        420 
PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT IDIFNEPICP PCGSFIRSYA 

       430        440        450        460        470        480 
SDIDTAVADK QLAVRYHLLN FLDDQSHSKN YSTRAVAASY CVAGQNDPKL YASFYSALFG 

       490        500        510        520        530        540 
SDFQPQENAA SDRTDAELAH LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA 

       550        560 
SGTPFVWDGS MVVNYQDPSW LARLIG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248340 Genomic DNA. Translation: CAD94474.1.
RefSeqNP_855424.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TZN3.
SMRQ7TZN3. Positions 14-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94474; CAD94474; Mb1772.
GeneID1092804.
KEGGmbo:Mb1772.
PATRIC18005580. VBIMycBov88188_1935.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000050013.
KOK08884.
OMATTTIDIF.
OrthoDBEOG6B35XT.
ProtClustDBCLSK791367.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNE_MYCBO
AccessionPrimary (citable) accession number: Q7TZN3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families