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Q7TZN3

- PKNE_MYCBO

UniProt

Q7TZN3 - PKNE_MYCBO

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Protein

Serine/threonine-protein kinase PknE

Gene

pknE

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknE (EC:2.7.11.1)
Gene namesi
Name:pknE
Ordered Locus Names:Mb1772
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 337337CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Topological domaini359 – 566208ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Serine/threonine-protein kinase PknEPRO_0000171210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine; by autocatalysisBy similarity
Modified residuei11 – 111Phosphothreonine; by autocatalysisBy similarity
Modified residuei50 – 501Phosphothreonine; by autocatalysisBy similarity
Modified residuei59 – 591Phosphothreonine; by autocatalysisBy similarity
Modified residuei170 – 1701Phosphothreonine; by autocatalysisBy similarity
Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity
Modified residuei178 – 1781Phosphothreonine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated on serine and threonine residues. Dephosphorylated by PstP (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1772.

Structurei

3D structure databases

ProteinModelPortaliQ7TZN3.
SMRiQ7TZN3. Positions 14-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 275260Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000050013.
KOiK08884.
OMAiTTTIDIF.
OrthoDBiEOG6B35XT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TZN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET
60 70 80 90 100
LSSDPDFRTR MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD
110 120 130 140 150
LAAMLRRQGP LAPPRAVAIV RQIGSALDAA HAAGATHRDV KPENILVSAD
160 170 180 190 200
DFAYLVDFGI ASATTDEKLT QLGNTVGTLY YMAPERFSES HATYRADIYA
210 220 230 240 250
LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG IPVAFDAVIA
260 270 280 290 300
RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST
310 320 330 340 350
HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL
360 370 380 390 400
AGGLGIALAH PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT
410 420 430 440 450
IDIFNEPICP PCGSFIRSYA SDIDTAVADK QLAVRYHLLN FLDDQSHSKN
460 470 480 490 500
YSTRAVAASY CVAGQNDPKL YASFYSALFG SDFQPQENAA SDRTDAELAH
510 520 530 540 550
LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA SGTPFVWDGS
560
MVVNYQDPSW LARLIG
Length:566
Mass (Da):60,528
Last modified:October 1, 2003 - v1
Checksum:i6F7534068DE608A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1.
RefSeqiNP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94474; CAD94474; Mb1772.
GeneIDi1092804.
KEGGimbo:Mb1772.
PATRICi18005580. VBIMycBov88188_1935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1 .
RefSeqi NP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TZN3.
SMRi Q7TZN3. Positions 14-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94474 ; CAD94474 ; Mb1772 .
GeneIDi 1092804.
KEGGi mbo:Mb1772.
PATRICi 18005580. VBIMycBov88188_1935.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000050013.
KOi K08884.
OMAi TTTIDIF.
OrthoDBi EOG6B35XT.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNE_MYCBO
AccessioniPrimary (citable) accession number: Q7TZN3
Secondary accession number(s): X2BJ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3