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Q7TZN3

- PKNE_MYCBO

UniProt

Q7TZN3 - PKNE_MYCBO

Protein

Serine/threonine-protein kinase PknE

Gene

pknE

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451ATPPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknE (EC:2.7.11.1)
    Gene namesi
    Name:pknE
    Ordered Locus Names:Mb1772
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Serine/threonine-protein kinase PknEPRO_0000171210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71Phosphoserine; by autocatalysisBy similarity
    Modified residuei11 – 111Phosphothreonine; by autocatalysisBy similarity
    Modified residuei50 – 501Phosphothreonine; by autocatalysisBy similarity
    Modified residuei59 – 591Phosphothreonine; by autocatalysisBy similarity
    Modified residuei170 – 1701Phosphothreonine; by autocatalysisBy similarity
    Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity
    Modified residuei178 – 1781Phosphothreonine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues. Dephosphorylated by PstP By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb1772.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TZN3.
    SMRiQ7TZN3. Positions 14-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 337337CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini359 – 566208ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 275260Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000050013.
    KOiK08884.
    OMAiTTTIDIF.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF13462. Thioredoxin_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TZN3-1 [UniParc]FASTAAdd to Basket

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    MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET    50
    LSSDPDFRTR MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD 100
    LAAMLRRQGP LAPPRAVAIV RQIGSALDAA HAAGATHRDV KPENILVSAD 150
    DFAYLVDFGI ASATTDEKLT QLGNTVGTLY YMAPERFSES HATYRADIYA 200
    LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG IPVAFDAVIA 250
    RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST 300
    HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL 350
    AGGLGIALAH PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT 400
    IDIFNEPICP PCGSFIRSYA SDIDTAVADK QLAVRYHLLN FLDDQSHSKN 450
    YSTRAVAASY CVAGQNDPKL YASFYSALFG SDFQPQENAA SDRTDAELAH 500
    LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA SGTPFVWDGS 550
    MVVNYQDPSW LARLIG 566
    Length:566
    Mass (Da):60,528
    Last modified:October 1, 2003 - v1
    Checksum:i6F7534068DE608A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43020.1.
    RefSeqiNP_855424.1. NC_002945.3.
    WP_010950585.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD94474; CAD94474; Mb1772.
    GeneIDi1092804.
    KEGGimbo:Mb1772.
    PATRICi18005580. VBIMycBov88188_1935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43020.1 .
    RefSeqi NP_855424.1. NC_002945.3.
    WP_010950585.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TZN3.
    SMRi Q7TZN3. Positions 14-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD94474 ; CAD94474 ; Mb1772 .
    GeneIDi 1092804.
    KEGGi mbo:Mb1772.
    PATRICi 18005580. VBIMycBov88188_1935.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000050013.
    KOi K08884.
    OMAi TTTIDIF.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF13462. Thioredoxin_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPKNE_MYCBO
    AccessioniPrimary (citable) accession number: Q7TZN3
    Secondary accession number(s): X2BJ35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3