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Protein

Serine/threonine-protein kinase PknE

Gene

pknE

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknE (EC:2.7.11.1)
Gene namesi
Name:pknE
Ordered Locus Names:Mb1772
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 337CytoplasmicSequence analysisAdd BLAST337
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 566ExtracellularSequence analysisAdd BLAST208

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712101 – 566Serine/threonine-protein kinase PknEAdd BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by autocatalysisBy similarity1
Modified residuei11Phosphothreonine; by autocatalysisBy similarity1
Modified residuei50Phosphothreonine; by autocatalysisBy similarity1
Modified residuei59Phosphothreonine; by autocatalysisBy similarity1
Modified residuei170Phosphothreonine; by autocatalysisBy similarity1
Modified residuei175Phosphothreonine; by autocatalysisBy similarity1
Modified residuei178Phosphothreonine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylated on serine and threonine residues. Dephosphorylated by PstP (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7TZN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 275Protein kinasePROSITE-ProRule annotationAdd BLAST260

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000050013.
KOiK08884.
OMAiKLAVRYH.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET
60 70 80 90 100
LSSDPDFRTR MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD
110 120 130 140 150
LAAMLRRQGP LAPPRAVAIV RQIGSALDAA HAAGATHRDV KPENILVSAD
160 170 180 190 200
DFAYLVDFGI ASATTDEKLT QLGNTVGTLY YMAPERFSES HATYRADIYA
210 220 230 240 250
LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG IPVAFDAVIA
260 270 280 290 300
RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST
310 320 330 340 350
HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL
360 370 380 390 400
AGGLGIALAH PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT
410 420 430 440 450
IDIFNEPICP PCGSFIRSYA SDIDTAVADK QLAVRYHLLN FLDDQSHSKN
460 470 480 490 500
YSTRAVAASY CVAGQNDPKL YASFYSALFG SDFQPQENAA SDRTDAELAH
510 520 530 540 550
LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA SGTPFVWDGS
560
MVVNYQDPSW LARLIG
Length:566
Mass (Da):60,528
Last modified:October 1, 2003 - v1
Checksum:i6F7534068DE608A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1.
RefSeqiNP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43020; CDO43020; Mb1772.
GeneIDi1092804.
KEGGimbo:Mb1772.
PATRICi18005580. VBIMycBov88188_1935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1.
RefSeqiNP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TZN3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43020; CDO43020; Mb1772.
GeneIDi1092804.
KEGGimbo:Mb1772.
PATRICi18005580. VBIMycBov88188_1935.

Phylogenomic databases

HOGENOMiHOG000050013.
KOiK08884.
OMAiKLAVRYH.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNE_MYCBO
AccessioniPrimary (citable) accession number: Q7TZN3
Secondary accession number(s): X2BJ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.