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Q7TZN3

- PKNE_MYCBO

UniProt

Q7TZN3 - PKNE_MYCBO

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Protein
Serine/threonine-protein kinase PknE
Gene
pknE, Mb1772
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATP By similarity
Active sitei139 – 1391Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknE (EC:2.7.11.1)
Gene namesi
Name:pknE
Ordered Locus Names:Mb1772
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 337337Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Topological domaini359 – 566208Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Serine/threonine-protein kinase PknE
PRO_0000171210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine; by autocatalysis By similarity
Modified residuei11 – 111Phosphothreonine; by autocatalysis By similarity
Modified residuei50 – 501Phosphothreonine; by autocatalysis By similarity
Modified residuei59 – 591Phosphothreonine; by autocatalysis By similarity
Modified residuei170 – 1701Phosphothreonine; by autocatalysis By similarity
Modified residuei175 – 1751Phosphothreonine; by autocatalysis By similarity
Modified residuei178 – 1781Phosphothreonine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated on serine and threonine residues. Dephosphorylated by PstP By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1772.

Structurei

3D structure databases

ProteinModelPortaliQ7TZN3.
SMRiQ7TZN3. Positions 14-268.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 275260Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000050013.
KOiK08884.
OMAiTTTIDIF.
OrthoDBiEOG6B35XT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TZN3-1 [UniParc]FASTAAdd to Basket

« Hide

MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET    50
LSSDPDFRTR MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD 100
LAAMLRRQGP LAPPRAVAIV RQIGSALDAA HAAGATHRDV KPENILVSAD 150
DFAYLVDFGI ASATTDEKLT QLGNTVGTLY YMAPERFSES HATYRADIYA 200
LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG IPVAFDAVIA 250
RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST 300
HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL 350
AGGLGIALAH PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT 400
IDIFNEPICP PCGSFIRSYA SDIDTAVADK QLAVRYHLLN FLDDQSHSKN 450
YSTRAVAASY CVAGQNDPKL YASFYSALFG SDFQPQENAA SDRTDAELAH 500
LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA SGTPFVWDGS 550
MVVNYQDPSW LARLIG 566
Length:566
Mass (Da):60,528
Last modified:October 1, 2003 - v1
Checksum:i6F7534068DE608A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1.
RefSeqiNP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94474; CAD94474; Mb1772.
GeneIDi1092804.
KEGGimbo:Mb1772.
PATRICi18005580. VBIMycBov88188_1935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43020.1 .
RefSeqi NP_855424.1. NC_002945.3.
WP_010950585.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TZN3.
SMRi Q7TZN3. Positions 14-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94474 ; CAD94474 ; Mb1772 .
GeneIDi 1092804.
KEGGi mbo:Mb1772.
PATRICi 18005580. VBIMycBov88188_1935.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000050013.
KOi K08884.
OMAi TTTIDIF.
OrthoDBi EOG6B35XT.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF13462. Thioredoxin_4. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNE_MYCBO
AccessioniPrimary (citable) accession number: Q7TZN3
Secondary accession number(s): X2BJ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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