Serine/threonine-protein kinase PknF - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

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Q7TZN1 (PKNF_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknF
EC=2.7.11.1

Gene names

Name:	pknF
Ordered Locus Names:	Mb1775

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Post-translational modification

Dephosphorylated by PstP By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

476

Serine/threonine-protein kinase PknF

PRO_0000171212

Regions

Domain

268

Protein kinase

Nucleotide binding

9

ATP By similarity

Sites

Active site

1

Proton acceptor By similarity

Binding site

1

ATP By similarity

Amino acid modifications

Modified residue

1

Phosphothreonine; by autocatalysis By similarity

Modified residue

1

Phosphothreonine; by autocatalysis By similarity

Modified residue

1

Phosphothreonine; by autocatalysis By similarity

Modified residue

1

Phosphothreonine; by autocatalysis By similarity

Modified residue

1

Phosphothreonine; by autocatalysis By similarity

Modified residue

1

Phosphoserine; by autocatalysis By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q7TZN1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: FD16541A9139163C
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476

50,698

        10         20         30         40         50         60 
MPLAEGSTFA GFTIVRQLGS GGMGEVYLAR HPRLPRQDAL KVLRADVSAD GEYRARFNRE 

        70         80         90        100        110        120 
ADAAASLWHP HIVAVHDRGE FDGQLWIDMD FVDGTDTVSL LRDRYPNGMP GPEVTEIITA 

       130        140        150        160        170        180 
VAEALDYAHE RRLLHRDVKP ANILIANPDS PDRRIMLADF GIAGWVDDPS GLTATNMTVG 

       190        200        210        220        230        240 
TVSYAAPEQL MGNELDGRAD QYALAATAFH LLTGSPPFQH ANPAVVISQH LSASPPAIGD 

       250        260        270        280        290        300 
RVPELTPLDP VFAKALAKQP KDRYQRCVDF ARALGHRLGG AGDPDDTRVS QPVAVAAPAK 

       310        320        330        340        350        360 
RSLLRTAVIV PAVLAMLLVM AVAVTVREFQ RADDERAAQP ARTRTTTSAG TTTSVAPAST 

       370        380        390        400        410        420 
TRPAPTTPTT TGAADTATAS PTAAVVAIGA LCFPLGSTGT TKTGATAYCS TLQGTNTTIW 

       430        440        450        460        470 
SLTEDTVASP TVTATADPTE APLPIEQESP IRVCMQQTGQ TRRECREEIR RSNGWP

References

[1]

"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.

expand/collapse author list

Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248340 Genomic DNA. Translation: CAD94477.1.
RefSeq	NP_855427.1. NC_002945.3.
3D structure databases
ProteinModelPortal	Q7TZN1.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb1775.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD94477; CAD94477; Mb1775.
GeneID	1092808.
KEGG	mbo:Mb1775.
PATRIC	18005588. VBIMycBov88188_1939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000077804.
KO	K08884.
OMA	PATMVEV.
ProtClustDB	CLSK791369.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKNF_MYCBO

Accession

Primary (citable) accession number: Q7TZN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents