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Protein

Serine/threonine-protein kinase PknF

Gene

pknF

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1
Active sitei137Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknF (EC:2.7.11.1)
Gene namesi
Name:pknF
Ordered Locus Names:Mb1775
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712121 – 476Serine/threonine-protein kinase PknFAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8Phosphothreonine; by autocatalysisBy similarity1
Modified residuei13Phosphothreonine; by autocatalysisBy similarity1
Modified residuei173Phosphothreonine; by autocatalysisBy similarity1
Modified residuei175Phosphothreonine; by autocatalysisBy similarity1
Modified residuei287Phosphothreonine; by autocatalysisBy similarity1
Modified residuei290Phosphoserine; by autocatalysisBy similarity1

Post-translational modificationi

Dephosphorylated by PstP.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7TZN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 279Protein kinasePROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000077804.
KOiK08884.
OMAiPEIVEGH.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TZN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAEGSTFA GFTIVRQLGS GGMGEVYLAR HPRLPRQDAL KVLRADVSAD
60 70 80 90 100
GEYRARFNRE ADAAASLWHP HIVAVHDRGE FDGQLWIDMD FVDGTDTVSL
110 120 130 140 150
LRDRYPNGMP GPEVTEIITA VAEALDYAHE RRLLHRDVKP ANILIANPDS
160 170 180 190 200
PDRRIMLADF GIAGWVDDPS GLTATNMTVG TVSYAAPEQL MGNELDGRAD
210 220 230 240 250
QYALAATAFH LLTGSPPFQH ANPAVVISQH LSASPPAIGD RVPELTPLDP
260 270 280 290 300
VFAKALAKQP KDRYQRCVDF ARALGHRLGG AGDPDDTRVS QPVAVAAPAK
310 320 330 340 350
RSLLRTAVIV PAVLAMLLVM AVAVTVREFQ RADDERAAQP ARTRTTTSAG
360 370 380 390 400
TTTSVAPAST TRPAPTTPTT TGAADTATAS PTAAVVAIGA LCFPLGSTGT
410 420 430 440 450
TKTGATAYCS TLQGTNTTIW SLTEDTVASP TVTATADPTE APLPIEQESP
460 470
IRVCMQQTGQ TRRECREEIR RSNGWP
Length:476
Mass (Da):50,698
Last modified:October 1, 2003 - v1
Checksum:iFD16541A9139163C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43023.1.
RefSeqiNP_855427.1. NC_002945.3.
WP_010950588.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43023; CDO43023; Mb1775.
GeneIDi1092808.
KEGGimbo:Mb1775.
PATRICi18005588. VBIMycBov88188_1939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43023.1.
RefSeqiNP_855427.1. NC_002945.3.
WP_010950588.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TZN1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43023; CDO43023; Mb1775.
GeneIDi1092808.
KEGGimbo:Mb1775.
PATRICi18005588. VBIMycBov88188_1939.

Phylogenomic databases

HOGENOMiHOG000077804.
KOiK08884.
OMAiPEIVEGH.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNF_MYCBO
AccessioniPrimary (citable) accession number: Q7TZN1
Secondary accession number(s): X2BJ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.