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Q7TZN1

- PKNF_MYCBO

UniProt

Q7TZN1 - PKNF_MYCBO

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Protein

Serine/threonine-protein kinase PknF

Gene

pknF

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATPPROSITE-ProRule annotation
Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknF (EC:2.7.11.1)
Gene namesi
Name:pknF
Ordered Locus Names:Mb1775
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Serine/threonine-protein kinase PknFPRO_0000171212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphothreonine; by autocatalysisBy similarity
Modified residuei13 – 131Phosphothreonine; by autocatalysisBy similarity
Modified residuei173 – 1731Phosphothreonine; by autocatalysisBy similarity
Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity
Modified residuei287 – 2871Phosphothreonine; by autocatalysisBy similarity
Modified residuei290 – 2901Phosphoserine; by autocatalysisBy similarity

Post-translational modificationi

Dephosphorylated by PstP.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1775.

Structurei

3D structure databases

ProteinModelPortaliQ7TZN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 279268Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000077804.
KOiK08884.
OMAiPEIVEGH.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TZN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLAEGSTFA GFTIVRQLGS GGMGEVYLAR HPRLPRQDAL KVLRADVSAD
60 70 80 90 100
GEYRARFNRE ADAAASLWHP HIVAVHDRGE FDGQLWIDMD FVDGTDTVSL
110 120 130 140 150
LRDRYPNGMP GPEVTEIITA VAEALDYAHE RRLLHRDVKP ANILIANPDS
160 170 180 190 200
PDRRIMLADF GIAGWVDDPS GLTATNMTVG TVSYAAPEQL MGNELDGRAD
210 220 230 240 250
QYALAATAFH LLTGSPPFQH ANPAVVISQH LSASPPAIGD RVPELTPLDP
260 270 280 290 300
VFAKALAKQP KDRYQRCVDF ARALGHRLGG AGDPDDTRVS QPVAVAAPAK
310 320 330 340 350
RSLLRTAVIV PAVLAMLLVM AVAVTVREFQ RADDERAAQP ARTRTTTSAG
360 370 380 390 400
TTTSVAPAST TRPAPTTPTT TGAADTATAS PTAAVVAIGA LCFPLGSTGT
410 420 430 440 450
TKTGATAYCS TLQGTNTTIW SLTEDTVASP TVTATADPTE APLPIEQESP
460 470
IRVCMQQTGQ TRRECREEIR RSNGWP
Length:476
Mass (Da):50,698
Last modified:October 1, 2003 - v1
Checksum:iFD16541A9139163C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43023.1.
RefSeqiNP_855427.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94477; CAD94477; Mb1775.
GeneIDi1092808.
KEGGimbo:Mb1775.
PATRICi18005588. VBIMycBov88188_1939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43023.1 .
RefSeqi NP_855427.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TZN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94477 ; CAD94477 ; Mb1775 .
GeneIDi 1092808.
KEGGi mbo:Mb1775.
PATRICi 18005588. VBIMycBov88188_1939.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000077804.
KOi K08884.
OMAi PEIVEGH.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNF_MYCBO
AccessioniPrimary (citable) accession number: Q7TZN1
Secondary accession number(s): X2BJ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3