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Q7TZN1

- PKNF_MYCBO

UniProt

Q7TZN1 - PKNF_MYCBO

Protein

Serine/threonine-protein kinase PknF

Gene

pknF

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATPPROSITE-ProRule annotation
    Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknF (EC:2.7.11.1)
    Gene namesi
    Name:pknF
    Ordered Locus Names:Mb1775
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Serine/threonine-protein kinase PknFPRO_0000171212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81Phosphothreonine; by autocatalysisBy similarity
    Modified residuei13 – 131Phosphothreonine; by autocatalysisBy similarity
    Modified residuei173 – 1731Phosphothreonine; by autocatalysisBy similarity
    Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity
    Modified residuei287 – 2871Phosphothreonine; by autocatalysisBy similarity
    Modified residuei290 – 2901Phosphoserine; by autocatalysisBy similarity

    Post-translational modificationi

    Dephosphorylated by PstP.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb1775.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TZN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 279268Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000077804.
    KOiK08884.
    OMAiPEIVEGH.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TZN1-1 [UniParc]FASTAAdd to Basket

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    MPLAEGSTFA GFTIVRQLGS GGMGEVYLAR HPRLPRQDAL KVLRADVSAD    50
    GEYRARFNRE ADAAASLWHP HIVAVHDRGE FDGQLWIDMD FVDGTDTVSL 100
    LRDRYPNGMP GPEVTEIITA VAEALDYAHE RRLLHRDVKP ANILIANPDS 150
    PDRRIMLADF GIAGWVDDPS GLTATNMTVG TVSYAAPEQL MGNELDGRAD 200
    QYALAATAFH LLTGSPPFQH ANPAVVISQH LSASPPAIGD RVPELTPLDP 250
    VFAKALAKQP KDRYQRCVDF ARALGHRLGG AGDPDDTRVS QPVAVAAPAK 300
    RSLLRTAVIV PAVLAMLLVM AVAVTVREFQ RADDERAAQP ARTRTTTSAG 350
    TTTSVAPAST TRPAPTTPTT TGAADTATAS PTAAVVAIGA LCFPLGSTGT 400
    TKTGATAYCS TLQGTNTTIW SLTEDTVASP TVTATADPTE APLPIEQESP 450
    IRVCMQQTGQ TRRECREEIR RSNGWP 476
    Length:476
    Mass (Da):50,698
    Last modified:October 1, 2003 - v1
    Checksum:iFD16541A9139163C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43023.1.
    RefSeqiNP_855427.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD94477; CAD94477; Mb1775.
    GeneIDi1092808.
    KEGGimbo:Mb1775.
    PATRICi18005588. VBIMycBov88188_1939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43023.1 .
    RefSeqi NP_855427.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TZN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1775.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD94477 ; CAD94477 ; Mb1775 .
    GeneIDi 1092808.
    KEGGi mbo:Mb1775.
    PATRICi 18005588. VBIMycBov88188_1939.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000077804.
    KOi K08884.
    OMAi PEIVEGH.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPKNF_MYCBO
    AccessioniPrimary (citable) accession number: Q7TZN1
    Secondary accession number(s): X2BJ00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3