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Q7TYY6

- PKNL_MYCBO

UniProt

Q7TYY6 - PKNL_MYCBO

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Protein

Serine/threonine-protein kinase PknL

Gene

pknL

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATPPROSITE-ProRule annotation
Active sitei142 – 1421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 339ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknL (EC:2.7.11.1)
Gene namesi
Name:pknL
Ordered Locus Names:Mb2198
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 368368CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Topological domaini390 – 39910ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Serine/threonine-protein kinase PknLPRO_0000171225Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2198.

Structurei

3D structure databases

ProteinModelPortaliQ7TYY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 278260Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037187.
KOiK08884.
OMAiIVENIGS.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TYY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEAGTRDPL ESALLDSRYL VQAKIASGGT STVYRGLDVR LDRPVALKVM
60 70 80 90 100
DARYAGDEQF LTRFRLEARA VARLNNRALV AVYDQGKDGR HPFLVMELIE
110 120 130 140 150
GGTLRELLIE RGPMPPHAVV AVLRPVLGGL AAAHRAGLVH RDVKPENILI
160 170 180 190 200
SDDGDVKLAD FGLVRAVAAA SITSTGVILG TAAYLSPEQV RDGNADPRSD
210 220 230 240 250
VYSVGVLVYE LLTGHTPFTG DSALSIAYQR LDADVPRASA VIDGVPPQFD
260 270 280 290 300
ELVACATARN PADRYADAIA MGADLEAIAE ELALPEFRVP APRNSAQHRS
310 320 330 340 350
AALYRSRITQ QGQLGAKPVH HPTRQLTRQP GDCSEPASGS EPEHEPITGQ
360 370 380 390
FAGIAIEEFI WARQHARRMV LVWVSVVLAI TGLVASAAWT IGSNLSGLL
Length:399
Mass (Da):42,818
Last modified:October 1, 2003 - v1
Checksum:iE896CEA19FB5A16A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43452.1.
RefSeqiNP_855847.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97051; CAD97051; Mb2198.
GeneIDi1091294.
KEGGimbo:Mb2198.
PATRICi18006536. VBIMycBov88188_2414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43452.1 .
RefSeqi NP_855847.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TYY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2198.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97051 ; CAD97051 ; Mb2198 .
GeneIDi 1091294.
KEGGi mbo:Mb2198.
PATRICi 18006536. VBIMycBov88188_2414.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000037187.
KOi K08884.
OMAi IVENIGS.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNL_MYCBO
AccessioniPrimary (citable) accession number: Q7TYY6
Secondary accession number(s): X2BJJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3