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Protein

Long-chain-fatty-acid--CoA ligase FadD15

Gene

fadD15

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway:ifatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD15 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD15
Ordered Locus Names:Mb2210
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Long-chain-fatty-acid--CoA ligase FadD15PRO_0000406785Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7TYX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000229985.
KOiK01897.
OrthoDBiEOG64FKGZ.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TYX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE
60 70 80 90 100
AANQIRAAAL GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPI
110 120 130 140 150
YETSSAEQVR WVLQDSEAVV LFAETDSHAT MVAELSGSVP ALREVLQIAG
160 170 180 190 200
SGPNALDRLT EAGASVDPAE LTARLAALRS TDPATLIYTS GTTGRPKGCQ
210 220 230 240 250
LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA ISMAAFHSKV
260 270 280 290 300
TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF
310 320 330 340 350
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV
360 370 380 390 400
SGGAPLGARL GHFYRGAGLT IYEGYGLSET SGGVAISQFN DLKIGTVGKP
410 420 430 440 450
VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD
460 470 480 490 500
EDGFLTITGR KKEIIVTAGG KNVAPAVLED QLRAHPLISQ AVVVGDAKPF
510 520 530 540 550
IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI DAAVKQANLA
560 570 580 590 600
VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE
Length:600
Mass (Da):64,119
Last modified:April 5, 2011 - v2
Checksum:i35DBF7534995F6C8
GO

Sequence cautioni

The sequence CDO43464.1 differs from that shown. Reason: Frameshift at position 91. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43464.1. Frameshift.
RefSeqiNP_855859.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43464; CDO43464; Mb2210.
GeneIDi1091318.
KEGGimbo:Mb2210.
PATRICi18006558. VBIMycBov88188_2425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43464.1. Frameshift.
RefSeqiNP_855859.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TYX8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43464; CDO43464; Mb2210.
GeneIDi1091318.
KEGGimbo:Mb2210.
PATRICi18006558. VBIMycBov88188_2425.

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000229985.
KOiK01897.
OrthoDBiEOG64FKGZ.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC15_MYCBO
AccessioniPrimary (citable) accession number: Q7TYX8
Secondary accession number(s): X2BK09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 22, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.