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Q7TYX8 (FAC15_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase FadD15

Short name=FACL
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD15
Ordered Locus Names:Mb2210
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence caution

The sequence CDO43464.1 differs from that shown. Reason: Frameshift at position 91.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Long-chain-fatty-acid--CoA ligase FadD15
PRO_0000406785

Sequences

Sequence LengthMass (Da)Tools
Q7TYX8 [UniParc].

Last modified April 5, 2011. Version 2.
Checksum: 35DBF7534995F6C8

FASTA60064,119
        10         20         30         40         50         60 
MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE AANQIRAAAL 

        70         80         90        100        110        120 
GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPI YETSSAEQVR WVLQDSEAVV 

       130        140        150        160        170        180 
LFAETDSHAT MVAELSGSVP ALREVLQIAG SGPNALDRLT EAGASVDPAE LTARLAALRS 

       190        200        210        220        230        240 
TDPATLIYTS GTTGRPKGCQ LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA 

       250        260        270        280        290        300 
ISMAAFHSKV TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF 

       310        320        330        340        350        360 
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV SGGAPLGARL 

       370        380        390        400        410        420 
GHFYRGAGLT IYEGYGLSET SGGVAISQFN DLKIGTVGKP VPGNSLRIAD DGELLVRGGV 

       430        440        450        460        470        480 
VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD EDGFLTITGR KKEIIVTAGG KNVAPAVLED 

       490        500        510        520        530        540 
QLRAHPLISQ AVVVGDAKPF IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI 

       550        560        570        580        590        600 
DAAVKQANLA VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO43464.1. Frameshift.
RefSeqNP_855859.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TYX8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2210.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD97063; CAD97063; Mb2210.
GeneID1091318.
KEGGmbo:Mb2210.
PATRIC18006558. VBIMycBov88188_2425.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1022.
HOGENOMHOG000229985.
KOK01897.
OrthoDBEOG64FKGZ.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC15_MYCBO
AccessionPrimary (citable) accession number: Q7TYX8
Secondary accession number(s): X2BK09
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways