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Protein

Long-chain-fatty-acid--CoA ligase FadD15

Gene

fadD15

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD15 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD15
Ordered Locus Names:BQ2027_MB2210
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004067851 – 600Long-chain-fatty-acid--CoA ligase FadD15Add BLAST600

Structurei

3D structure databases

ProteinModelPortaliQ7TYX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000229985.
KOiK01897.

Family and domain databases

InterProiView protein in InterPro
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TYX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE
60 70 80 90 100
AANQIRAAAL GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPI
110 120 130 140 150
YETSSAEQVR WVLQDSEAVV LFAETDSHAT MVAELSGSVP ALREVLQIAG
160 170 180 190 200
SGPNALDRLT EAGASVDPAE LTARLAALRS TDPATLIYTS GTTGRPKGCQ
210 220 230 240 250
LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA ISMAAFHSKV
260 270 280 290 300
TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF
310 320 330 340 350
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV
360 370 380 390 400
SGGAPLGARL GHFYRGAGLT IYEGYGLSET SGGVAISQFN DLKIGTVGKP
410 420 430 440 450
VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD
460 470 480 490 500
EDGFLTITGR KKEIIVTAGG KNVAPAVLED QLRAHPLISQ AVVVGDAKPF
510 520 530 540 550
IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI DAAVKQANLA
560 570 580 590 600
VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE
Length:600
Mass (Da):64,119
Last modified:April 5, 2011 - v2
Checksum:i35DBF7534995F6C8
GO

Sequence cautioni

The sequence SIU00818 differs from that shown. Reason: Frameshift at position 91.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU00818.1. Frameshift.

Genome annotation databases

EnsemblBacteriaiCDO43464; CDO43464; Mb2210.
KEGGimbo:Mb2210.
PATRICifig|233413.5.peg.2425.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFAC15_MYCBO
AccessioniPrimary (citable) accession number: Q7TYX8
Secondary accession number(s): A0A1R3Y0F3, X2BK09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families