Q7TYW7 (Q7TYW7_MYCBO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156

Gene names

Name:	aceE EMBL CAD97118.1
Ordered Locus Names:	Mb2265

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	901 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156
Cofactor	Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Ontologies

Keywords
Ligand	Pyruvate PIRNR PIRNR000156 EMBL CAD97118.1 Thiamine pyrophosphate PIRNR PIRNR000156
Molecular function	Oxidoreductase PIRNR PIRNR000156 EMBL CAD97118.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7TYW7 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 06751F5F2D80C704	FASTA	901	100,316
	10 20 30 40 50 60 MASYLPDIDP EETSEWLESF DTLLQRCGPS RARYLMLRLL ERAGEQRVAI PALTSTDYVN 70 80 90 100 110 120 TIPTELEPWF PGDEDVERRY RAWIRWNAAI MVHRAQRPGV GVGGHISTYA SSAALYEVGF 130 140 150 160 170 180 NHFFRGKSHP GGGDQVFIQG HASPGIYARA FLEGRLTAEQ LDGFRQEHSH VGGGLPSYPH 190 200 210 220 230 240 PRLMPDFWEF PTVSMGLGPL NAIYQARFNH YLHDRGIKDT SDQHVWCFLG DGEMDEPESR 250 260 270 280 290 300 GLAHVGALEG LDNLTFVINC NLQRLDGPVR GNGKIIQELE SFFRGAGWNV IKVVWGREWD 310 320 330 340 350 360 ALLHADRDRA LVNLMNTTPD GDYQTYKAND GGYVRDHFFG RDPRTKALVE NMSDQDIWNL 370 380 390 400 410 420 KRGGHDYRKV YAAYRAAVDH KGQPTVILAK TIKGYALGKH FEGRNATHQM KKLTLEDLKE 430 440 450 460 470 480 FRDTQRIPVS DAQLEENPYL PPYYHPGLNA PEIRYMLDRR RALGGFVPER RTKSKALTLP 490 500 510 520 530 540 GRDIYAPLKK GSGHQEVATT MATVRTFKEV LRDKQIGPRI VPIIPDEART FGMDSWFPSL 550 560 570 580 590 600 KIYNRNGQLY TAVDADLMLA YKESEVGQIL HEGINEAGSV GSFIAAGTSY ATHNEPMIPI 610 620 630 640 650 660 YIFYSMFGFQ RTGDSFWAAA DQMARGFVLG ATAGRTTLTG EGLQHADGHS LLLAATNPAV 670 680 690 700 710 720 VAYDPAFAYE IAYIVESGLA RMCGENPENI FFYITVYNEP YVQPPEPENF DPEGVLRGIY 730 740 750 760 770 780 RYHAATEQRT NKAQILASGV AMPAALRAAQ MLAAEWDVAA DVWSVTSWGE LNRDGVAIET 790 800 810 820 830 840 EKLRHPDRPA GVPYVTRALE NARGPVIAVS DWMRAVPEQI RPWVPGTYLT LGTDGFGFSD 850 860 870 880 890 900 TRPAARRYFN TDAESQVVAV LEALAGDGEI DPSVPVAAAR QYRIDDVAAA PEQTTDPGPG A

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248341 Genomic DNA. Translation: CAD97118.1.
RefSeq	NP_855914.1. NC_002945.3.
3D structure databases
ProteinModelPortal	Q7TYW7.
SMR	Q7TYW7. Positions 56-891.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000015765; EBMYCP00000015600; EBMYCG00000015761.
GeneID	1091403.
GenomeReviews	Gene locus Mb2265 in contig BX248333_GR.
KEGG	mbo:Mb2265.
PATRIC	18006682. VBIMycBov88188_2486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016271.
HOGENOM	HBG289271.
OMA	FRQEKSH.
ProtClustDB	PRK09405.
Family and domain databases
InterPro	IPR004660. 2-oxoA_DH_E1. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K00163.
PANTHER	PTHR11624:SF37. PTHR11624:SF37. 1 hit.
Pfam	PF00456. Transketolase_N. 1 hit. [Graphical view]
PIRSF	PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00759. AceE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7TYW7_MYCBO

Accession

Primary (citable) accession number: Q7TYW7

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)