Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q7TYQ9 (MBTG_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lysine 6-monooxygenase mbtG

EC=1.14.13.59
Alternative name(s):
Lysine 6-N-hydroxylase
Lysine N(6)-hydroxylase
Lysine-N-oxygenase
Mycobactin synthase protein G
Gene names
Name:mbtG
Ordered Locus Names:Mb2399c
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro By similarity.

Catalytic activity

L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + NADP+ + H2O.

Cofactor

FAD By similarity.

Pathway

Siderophore biosynthesis; mycobactin biosynthesis.

Sequence similarities

Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

Ontologies

Keywords
   DomainSignal
   LigandFAD
Flavoprotein
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionL-lysine 6-monooxygenase (NADPH) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 431410L-lysine 6-monooxygenase mbtG
PRO_0000261309

Sequences

Sequence LengthMass (Da)Tools
Q7TYQ9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8D200693CB6D4EB0

FASTA43146,944
        10         20         30         40         50         60 
MNPTLAVLGA GAKAVAVAAK ASVLRDMGVD VPDVIAVERI GVGANWQASG GWTDGAHRLG 

        70         80         90        100        110        120 
TSPEKDVGFP YRSALVPRRN AELDERMTRY SWQSYLIATA SFAEWIDRGR PAPTHRRWSQ 

       130        140        150        160        170        180 
YLAWVADHIG LKVIHGEVER LAVTGDRWAL CTHETTVQAD ALMITGPGQA EKSLLPGNPR 

       190        200        210        220        230        240 
VLSIAQFWDR AAGHDRINAE RVAVIGGGET AASMLNELFR HRVSTITVIS PQVTLFTRGE 

       250        260        270        280        290        300 
GFFENSLFSD PTDWAALTFD ERRDALARTD RGVFSATVQE ALLADDRIHH LRGRVAHAVG 

       310        320        330        340        350        360 
RQGQIRLTLS TNRGSENFET VHGFDLVIDG SGADPLWFTS LFSQHTLDLL ELGLGGPLTA 

       370        380        390        400        410        420 
DRLQEAIGYD LAVTDVTPKL FLPTLSGLTQ GPGFPNLSCL GLLSDRVLGA GIFTPTKHND 

       430 
TRRSGEHQSF R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248342 Genomic DNA. Translation: CAD97260.1.
RefSeqNP_856048.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TYQ9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000014929; EBMYCP00000014764; EBMYCG00000014926.
GeneID1094387.
GenomeReviewsGene locus Mb2399c in contig BX248333_GR.
KEGGmbo:Mb2399c.
PATRIC18006987. VBIMycBov88188_2636.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017267.
HOGENOMHBG432039.
OMAIAQFWHR.
ProtClustDBCLSK791811.

Enzyme and pathway databases

BioCycMBOV233413:MB2399C-MONOMER.

Family and domain databases

KOK04793.
ProtoNetSearch...

Entry information

Entry nameMBTG_MYCBO
AccessionPrimary (citable) accession number: Q7TYQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families