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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Mb2507c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789Glycerol-3-phosphate acyltransferasePRO_0000195223Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7TYH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi276 – 2816HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000045991.
KOiK00631.
OMAiEYLGEPH.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPAADASA VLTAEDTLVL ASTATPVEME LIMGWLGQQR ARHPDSKFDI
60 70 80 90 100
LKLPPRNAPP AALTALVEQL EPGFASSPQS GEDRSIVPVR VIWLPPADRS
110 120 130 140 150
RAGKVAALLP GRDPYHPSQR QQRRILRTDP RRARVVAGES AKVSELRQQW
160 170 180 190 200
RDTTVAEHKR DFAQFVSRRA LLALARAEYR ILGPQYKSPR LVKPEMLASA
210 220 230 240 250
RFRAGLDRIP GATVEDAGKM LDELSTGWSQ VSVDLVSVLG RLASRGFDPE
260 270 280 290 300
FDYDEYQVAA MRAALEAHPA VLLFSHRSYI DGVVVPVAMQ DNRLPPVHMF
310 320 330 340 350
GGINLSFGLM GPLMRRSGMI FIRRNIGNDP LYKYVLKEYV GYVVEKRFNL
360 370 380 390 400
SWSIEGTRSR TGKMLPPKLG LMSYVADAYL DGRSDDILLQ GVSICFDQLH
410 420 430 440 450
EITEYAAYAR GAEKTPEGLR WLYNFIKAQG ERNFGKIYVR FPEAVSMRQY
460 470 480 490 500
LGAPHGELTQ DPAAKRLALQ KMSFEVAWRI LQATPVTATG LVSALLLTTR
510 520 530 540 550
GTALTLDQLH HTLQDSLDYL ERKQSPVSTS ALRLRSREGV RAAADALSNG
560 570 580 590 600
HPVTRVDSGR EPVWYIAPDD EHAAAFYRSS VIHAFLETSI VELALAHAKH
610 620 630 640 650
AEGDRVAAFW AQAMRLRDLL KFDFYFADST AFRANIAQEM AWHQDWEDHL
660 670 680 690 700
GVGGNEIDAM LYAKRPLMSD AMLRVFFEAY EIVADVLRDA PPDIGPEELT
710 720 730 740 750
ELALGLGRQF VAQGRVRSSE PVSTLLFATA RQVAVDQELI APAADLAERR
760 770 780
VAFRRELRNI LRDFDYVEQI ARNQFVAREF KARQGRDRI
Length:789
Mass (Da):88,341
Last modified:October 1, 2003 - v1
Checksum:i85ACA549B9B1CFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43769.1.
RefSeqiNP_856154.1. NC_002945.3.
WP_010950725.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43769; CDO43769; Mb2507c.
GeneIDi1094205.
KEGGimbo:Mb2507c.
PATRICi18007237. VBIMycBov88188_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43769.1.
RefSeqiNP_856154.1. NC_002945.3.
WP_010950725.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TYH5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43769; CDO43769; Mb2507c.
GeneIDi1094205.
KEGGimbo:Mb2507c.
PATRICi18007237. VBIMycBov88188_2759.

Phylogenomic databases

HOGENOMiHOG000045991.
KOiK00631.
OMAiEYLGEPH.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_MYCBO
AccessioniPrimary (citable) accession number: Q7TYH5
Secondary accession number(s): X2BKY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.