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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:BQ2027_MB2507C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001952231 – 789Glycerol-3-phosphate acyltransferaseAdd BLAST789

Structurei

3D structure databases

ProteinModelPortaliQ7TYH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi276 – 281HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000045991.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiView protein in InterPro
IPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiView protein in Pfam
PF01553. Acyltransferase. 1 hit.
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiView protein in SMART
SM00563. PlsC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPAADASA VLTAEDTLVL ASTATPVEME LIMGWLGQQR ARHPDSKFDI
60 70 80 90 100
LKLPPRNAPP AALTALVEQL EPGFASSPQS GEDRSIVPVR VIWLPPADRS
110 120 130 140 150
RAGKVAALLP GRDPYHPSQR QQRRILRTDP RRARVVAGES AKVSELRQQW
160 170 180 190 200
RDTTVAEHKR DFAQFVSRRA LLALARAEYR ILGPQYKSPR LVKPEMLASA
210 220 230 240 250
RFRAGLDRIP GATVEDAGKM LDELSTGWSQ VSVDLVSVLG RLASRGFDPE
260 270 280 290 300
FDYDEYQVAA MRAALEAHPA VLLFSHRSYI DGVVVPVAMQ DNRLPPVHMF
310 320 330 340 350
GGINLSFGLM GPLMRRSGMI FIRRNIGNDP LYKYVLKEYV GYVVEKRFNL
360 370 380 390 400
SWSIEGTRSR TGKMLPPKLG LMSYVADAYL DGRSDDILLQ GVSICFDQLH
410 420 430 440 450
EITEYAAYAR GAEKTPEGLR WLYNFIKAQG ERNFGKIYVR FPEAVSMRQY
460 470 480 490 500
LGAPHGELTQ DPAAKRLALQ KMSFEVAWRI LQATPVTATG LVSALLLTTR
510 520 530 540 550
GTALTLDQLH HTLQDSLDYL ERKQSPVSTS ALRLRSREGV RAAADALSNG
560 570 580 590 600
HPVTRVDSGR EPVWYIAPDD EHAAAFYRSS VIHAFLETSI VELALAHAKH
610 620 630 640 650
AEGDRVAAFW AQAMRLRDLL KFDFYFADST AFRANIAQEM AWHQDWEDHL
660 670 680 690 700
GVGGNEIDAM LYAKRPLMSD AMLRVFFEAY EIVADVLRDA PPDIGPEELT
710 720 730 740 750
ELALGLGRQF VAQGRVRSSE PVSTLLFATA RQVAVDQELI APAADLAERR
760 770 780
VAFRRELRNI LRDFDYVEQI ARNQFVAREF KARQGRDRI
Length:789
Mass (Da):88,341
Last modified:October 1, 2003 - v1
Checksum:i85ACA549B9B1CFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU01123.1.
RefSeqiNP_856154.1. NC_002945.3.
WP_010950725.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO43769; CDO43769; Mb2507c.
KEGGimbo:Mb2507c.
PATRICifig|233413.5.peg.2759.

Similar proteinsi

Entry informationi

Entry nameiPLSB_MYCBO
AccessioniPrimary (citable) accession number: Q7TYH5
Secondary accession number(s): A0A1R3Y1A3, X2BKY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families