Q7TY47 (DCUP_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Mb2697c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm Probable HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187614
Regions
	Region	30 – 34	5	Substrate binding By similarity
Sites
	Binding site	79	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	336	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7TY47 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F3969976E6BBA1B3	FASTA	357	37,592
	10 20 30 40 50 60 MSTRRDLPQS PYLAAVTGRK PSRVPVWFMR QAGRSLPEYR ALRERYSMLA ACFEPDVACE 70 80 90 100 110 120 ITLQPIRRYD VDAAILFSDI VVPLRAAGVD LDIVADVGPV IADPVRTAAD VAAMKPLDPQ 130 140 150 160 170 180 AIQPVLVAAS LLVAELGDVP LIGFAGAPFT LASYLVEGGP SRHHAHVKAM MLAEPASWHA 190 200 210 220 230 240 LMAKLTDLTI AFLVGQIDAG VDAIQVFDSW AGALSPIDYR QYVLPHSARV FAALGEHGVP 250 260 270 280 290 300 MTHFGVGTAE LLGAMSEAVT AGERPGRGGV VGVDWRTPLT DAAARVVPGT ALQGNLDPAV 310 320 330 340 350 VLAGWPAVER AARAVVDDGR RAVDAGAAGH IFNLGHGVLP ESDPAVLADL VSLVHSL

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248343 Genomic DNA. Translation: CAD94882.1.
RefSeq	NP_856343.1. NC_002945.3.
3D structure databases
ProteinModelPortal	Q7TY47.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000014673; EBMYCP00000014508; EBMYCG00000014670.
GeneID	1091914.
GenomeReviews	Gene locus Mb2697c in contig BX248333_GR.
KEGG	mbo:Mb2697c.
PATRIC	18007647. VBIMycBov88188_2956.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016469.
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	MBOV233413:MB2697C-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_MYCBO

Accession

Primary (citable) accession number: Q7TY47

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program