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Q7TXL7

- PPSD_MYCBO

UniProt

Q7TXL7 - PPSD_MYCBO

Protein

Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD

Gene

ppsD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives, respectively.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein].PROSITE-ProRule annotation

    Cofactori

    Binds 1 phosphopantetheines covalently.By similarity
    NADP.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071For beta-ketoacyl synthase activityPROSITE-ProRule annotation
    Active sitei654 – 6541For malonyltransferase activityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1440 – 148546NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
    2. oxidoreductase activity Source: UniProtKB-KW
    3. phosphopantetheine binding Source: InterPro

    GO - Biological processi

    1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
    2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
    3. phenolic phthiocerol biosynthetic process Source: UniProtKB
    4. phthiocerol biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase, Transferase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD
    Alternative name(s):
    Beta-ketoacyl-acyl-carrier-protein synthase I (EC:2.3.1.41)
    Gene namesi
    Name:ppsD
    Ordered Locus Names:Mb2959
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. polyketide synthase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18271827Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsDPRO_0000406949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1745 – 17451O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2959.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TXL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1708 – 178275Acyl carrierPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 464427Beta-ketoacyl synthaseBy similarityAdd
    BLAST
    Regioni566 – 876311AcyltransferaseBy similarityAdd
    BLAST
    Regioni910 – 1076167DehydrataseBy similarityAdd
    BLAST
    Regioni1439 – 1617179Beta-ketoacyl reductaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 acyl carrier domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3321.
    HOGENOMiHOG000046292.
    KOiK12443.
    OMAiCARTHAE.
    OrthoDBiEOG6QP0WP.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProiIPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF08659. KR. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    SMARTiSM00827. PKS_AT. 1 hit.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 1 hit.
    SM00825. PKS_KS. 1 hit.
    SM00823. PKS_PP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53901. SSF53901. 1 hit.
    SSF55048. SSF55048. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TXL7-1 [UniParc]FASTAAdd to Basket

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    MTSLAERAAQ LSPNARAALA RELVRAGTTF PTDICEPVAV VGIGCRFPGN     50
    VTGPESFWQL LADGVDTIEQ VPPDRWDADA FYDPDPSASG RMTTKWGGFV 100
    SDVDAFDADF FGITPREAVA MDPQHRILLE VAWEALEHAG IPPDSLSGTR 150
    TGVMMGLSSW DYTIVNIERR ADIDAYLSTG TPHCAAVGRI AYLLGLRGPA 200
    VAVDTACSSS LVAIHLACQS LRLRETDVAL AGGVQLTLSP FTAIALSKWS 250
    ALSPTGRCNS FDANADGFVR GEGCGVVVLK RLADAVRDQD RVLAVVRGSA 300
    TNSDGRSNGM TAPNALAQRD VITSALKLAD VTPDSVNYVE THGTGTVLGD 350
    PIEFESLAAT YGLGKGQGES PCALGSVKTN IGHLEAAAGV AGFIKAVLAV 400
    QRGHIPRNLH FTRWNPAIDA SATRLFVPTE SAPWPAAAGP RRAAVSSFGL 450
    SGTNAHVVVE QAPDTAVAAA GGMPYVSALN VSGKTAARVA SAAAVLADWM 500
    SGPGAAAPLA DVAHTLNRHR ARHAKFATVI ARDRAEAIAG LRALAAGQPR 550
    VGVVDCDQHA GGPGRVFVYS GQGSQWASMG QQLLANEPAF AKAVAELDPI 600
    FVDQVGFSLQ QTLIDGDEVV GIDRIQPVLV GMQLALTELW RSYGVIPDAV 650
    IGHSMGEVSA AVVAGALTPE QGLRVITTRS RLMARLSGQG AMALLELDAD 700
    AAEALIAGYP QVTLAVHASP RQTVIAGPPE QVDTVIAAVA TQNRLARRVE 750
    VDVASHHPII DPILPELRSA LADLTPQPPS IPIISTTYES AQPVADADYW 800
    SANLRNPVRF HQAVTAAGVD HNTFIEISPH PVLTHALTDT LDPDGSHTVM 850
    STMNRELDQT LYFHAQLAAV GVAASEHTTG RLVDLPPTPW HHQRFWVTDR 900
    SAMSELAATH PLLGAHIEMP RNGDHVWQTD VGTEVCPWLA DHKVFGQPIM 950
    PAAGFAEIAL AAASEALGTA ADAVAPNIVI NQFEVEQMLP LDGHTPLTTQ 1000
    LIRGGDSQIR VEIYSRTRGG EFCRHATAKV EQSPRECAHA HPEAQGPATG 1050
    TTVSPADFYA LLRQTGQHHG PAFAALSRIV RLADGSAETE ISIPDEAPRH 1100
    PGYRLHPVVL DAALQSVGAA IPDGEIAGSA EASYLPVSFE TIRVYRDIGR 1150
    HVRCRAHLTN LDGGTGKMGR IVLINDAGHI AAEVDGIYLR RVERRAVPLP 1200
    LEQKIFDAEW TESPIAAVPA PEPAAETTRG SWLVLADATV DAPGKAQAKS 1250
    MADDFVQQWR SPMRRVHTAD IHDESAVLAA FAETAGDPEH PPVGVVVFVG 1300
    GASSRLDDEL AAARDTVWSI TTVVRAVVGT WHGRSPRLWL VTGGGLSVAD 1350
    DEPGTPAAAS LKGLVRVLAF EHPDMRTTLV DLDITQDPLT ALSAELRNAG 1400
    SGSRHDDVIA WRGERRFVER LSRATIDVSK GHPVVRQGAS YVVTGGLGGL 1450
    GLVVARWLVD RGAGRVVLGG RSDPTDEQCN VLAELQTRAE IVVVRGDVAS 1500
    PGVAEKLIET ARQSGGQLRG VVHAAAVIED SLVFSMSRDN LERVWAPKAT 1550
    GALRMHEATA DCELDWWLGF SSAASLLGSP GQAAYACASA WLDALVGWRR 1600
    ASGLPAAVIN WGPWSEVGVA QALVGSVLDT ISVAEGIEAL DSLLAADRIR 1650
    TGVARLRADR ALVAFPEIRS ISYFTQVVEE LDSAGDLGDW GGPDALADLD 1700
    PGEARRAVTE RMCARIAAVM GYTDQSTVEP AVPLDKPLTE LGLDSLMAVR 1750
    IRNGARADFG VEPPVALILQ GASLHDLTAD LMRQLGLNDP DPALNNADTI 1800
    RDRARQRAAA RHGAAMRRRP KPAVQGG 1827
    Length:1,827
    Mass (Da):193,238
    Last modified:October 1, 2003 - v1
    Checksum:i3081356D90C3FE71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44226.1.
    RefSeqiNP_856604.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96646; CAD96646; Mb2959.
    GeneIDi1092147.
    KEGGimbo:Mb2959.
    PATRICi18008230. VBIMycBov88188_3247.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44226.1 .
    RefSeqi NP_856604.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TXL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96646 ; CAD96646 ; Mb2959 .
    GeneIDi 1092147.
    KEGGi mbo:Mb2959.
    PATRICi 18008230. VBIMycBov88188_3247.

    Phylogenomic databases

    eggNOGi COG3321.
    HOGENOMi HOG000046292.
    KOi K12443.
    OMAi CARTHAE.
    OrthoDBi EOG6QP0WP.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProi IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF08659. KR. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00827. PKS_AT. 1 hit.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 1 hit.
    SM00825. PKS_KS. 1 hit.
    SM00823. PKS_PP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53901. SSF53901. 1 hit.
    SSF55048. SSF55048. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPPSD_MYCBO
    AccessioniPrimary (citable) accession number: Q7TXL7
    Secondary accession number(s): X2BMU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3