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Q7TXL7

- PPSD_MYCBO

UniProt

Q7TXL7 - PPSD_MYCBO

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Protein

Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD

Gene
ppsD, Mb2959
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives, respectively By similarity.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Cofactori

Binds 1 phosphopantetheines covalently By similarity.
NADP By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071For beta-ketoacyl synthase activity By similarity
Active sitei654 – 6541For malonyltransferase activity By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1440 – 148546NADP By similarityAdd
BLAST

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: UniProtKB-KW
  3. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  3. phenolic phthiocerol biosynthetic process Source: UniProtKB
  4. phthiocerol biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD
Alternative name(s):
Beta-ketoacyl-acyl-carrier-protein synthase I (EC:2.3.1.41)
Gene namesi
Name:ppsD
Ordered Locus Names:Mb2959
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. polyketide synthase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18271827Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsDPRO_0000406949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1745 – 17451O-(pantetheine 4'-phosphoryl)serine By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2959.

Structurei

3D structure databases

ProteinModelPortaliQ7TXL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1708 – 178275Acyl carrierAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 464427Beta-ketoacyl synthase By similarityAdd
BLAST
Regioni566 – 876311Acyltransferase By similarityAdd
BLAST
Regioni910 – 1076167Dehydratase By similarityAdd
BLAST
Regioni1439 – 1617179Beta-ketoacyl reductase By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3321.
HOGENOMiHOG000046292.
KOiK12443.
OMAiCARTHAE.
OrthoDBiEOG6QP0WP.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TXL7-1 [UniParc]FASTAAdd to Basket

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MTSLAERAAQ LSPNARAALA RELVRAGTTF PTDICEPVAV VGIGCRFPGN     50
VTGPESFWQL LADGVDTIEQ VPPDRWDADA FYDPDPSASG RMTTKWGGFV 100
SDVDAFDADF FGITPREAVA MDPQHRILLE VAWEALEHAG IPPDSLSGTR 150
TGVMMGLSSW DYTIVNIERR ADIDAYLSTG TPHCAAVGRI AYLLGLRGPA 200
VAVDTACSSS LVAIHLACQS LRLRETDVAL AGGVQLTLSP FTAIALSKWS 250
ALSPTGRCNS FDANADGFVR GEGCGVVVLK RLADAVRDQD RVLAVVRGSA 300
TNSDGRSNGM TAPNALAQRD VITSALKLAD VTPDSVNYVE THGTGTVLGD 350
PIEFESLAAT YGLGKGQGES PCALGSVKTN IGHLEAAAGV AGFIKAVLAV 400
QRGHIPRNLH FTRWNPAIDA SATRLFVPTE SAPWPAAAGP RRAAVSSFGL 450
SGTNAHVVVE QAPDTAVAAA GGMPYVSALN VSGKTAARVA SAAAVLADWM 500
SGPGAAAPLA DVAHTLNRHR ARHAKFATVI ARDRAEAIAG LRALAAGQPR 550
VGVVDCDQHA GGPGRVFVYS GQGSQWASMG QQLLANEPAF AKAVAELDPI 600
FVDQVGFSLQ QTLIDGDEVV GIDRIQPVLV GMQLALTELW RSYGVIPDAV 650
IGHSMGEVSA AVVAGALTPE QGLRVITTRS RLMARLSGQG AMALLELDAD 700
AAEALIAGYP QVTLAVHASP RQTVIAGPPE QVDTVIAAVA TQNRLARRVE 750
VDVASHHPII DPILPELRSA LADLTPQPPS IPIISTTYES AQPVADADYW 800
SANLRNPVRF HQAVTAAGVD HNTFIEISPH PVLTHALTDT LDPDGSHTVM 850
STMNRELDQT LYFHAQLAAV GVAASEHTTG RLVDLPPTPW HHQRFWVTDR 900
SAMSELAATH PLLGAHIEMP RNGDHVWQTD VGTEVCPWLA DHKVFGQPIM 950
PAAGFAEIAL AAASEALGTA ADAVAPNIVI NQFEVEQMLP LDGHTPLTTQ 1000
LIRGGDSQIR VEIYSRTRGG EFCRHATAKV EQSPRECAHA HPEAQGPATG 1050
TTVSPADFYA LLRQTGQHHG PAFAALSRIV RLADGSAETE ISIPDEAPRH 1100
PGYRLHPVVL DAALQSVGAA IPDGEIAGSA EASYLPVSFE TIRVYRDIGR 1150
HVRCRAHLTN LDGGTGKMGR IVLINDAGHI AAEVDGIYLR RVERRAVPLP 1200
LEQKIFDAEW TESPIAAVPA PEPAAETTRG SWLVLADATV DAPGKAQAKS 1250
MADDFVQQWR SPMRRVHTAD IHDESAVLAA FAETAGDPEH PPVGVVVFVG 1300
GASSRLDDEL AAARDTVWSI TTVVRAVVGT WHGRSPRLWL VTGGGLSVAD 1350
DEPGTPAAAS LKGLVRVLAF EHPDMRTTLV DLDITQDPLT ALSAELRNAG 1400
SGSRHDDVIA WRGERRFVER LSRATIDVSK GHPVVRQGAS YVVTGGLGGL 1450
GLVVARWLVD RGAGRVVLGG RSDPTDEQCN VLAELQTRAE IVVVRGDVAS 1500
PGVAEKLIET ARQSGGQLRG VVHAAAVIED SLVFSMSRDN LERVWAPKAT 1550
GALRMHEATA DCELDWWLGF SSAASLLGSP GQAAYACASA WLDALVGWRR 1600
ASGLPAAVIN WGPWSEVGVA QALVGSVLDT ISVAEGIEAL DSLLAADRIR 1650
TGVARLRADR ALVAFPEIRS ISYFTQVVEE LDSAGDLGDW GGPDALADLD 1700
PGEARRAVTE RMCARIAAVM GYTDQSTVEP AVPLDKPLTE LGLDSLMAVR 1750
IRNGARADFG VEPPVALILQ GASLHDLTAD LMRQLGLNDP DPALNNADTI 1800
RDRARQRAAA RHGAAMRRRP KPAVQGG 1827
Length:1,827
Mass (Da):193,238
Last modified:October 1, 2003 - v1
Checksum:i3081356D90C3FE71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44226.1.
RefSeqiNP_856604.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96646; CAD96646; Mb2959.
GeneIDi1092147.
KEGGimbo:Mb2959.
PATRICi18008230. VBIMycBov88188_3247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44226.1 .
RefSeqi NP_856604.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TXL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96646 ; CAD96646 ; Mb2959 .
GeneIDi 1092147.
KEGGi mbo:Mb2959.
PATRICi 18008230. VBIMycBov88188_3247.

Phylogenomic databases

eggNOGi COG3321.
HOGENOMi HOG000046292.
KOi K12443.
OMAi CARTHAE.
OrthoDBi EOG6QP0WP.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
SMARTi SM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPPSD_MYCBO
AccessioniPrimary (citable) accession number: Q7TXL7
Secondary accession number(s): X2BMU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi