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Q7TXL7 (PPSD_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD
Alternative name(s):
Beta-ketoacyl-acyl-carrier-protein synthase I
EC=2.3.1.41
Gene names
Name:ppsD
Ordered Locus Names:Mb2959
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length1827 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives, respectively By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Cofactor

Binds 1 phosphopantetheines covalently By similarity.

NADP By similarity.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Contains 1 acyl carrier domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18271827Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD
PRO_0000406949

Regions

Domain1708 – 178275Acyl carrier
Nucleotide binding1440 – 148546NADP By similarity
Region38 – 464427Beta-ketoacyl synthase By similarity
Region566 – 876311Acyltransferase By similarity
Region910 – 1076167Dehydratase By similarity
Region1439 – 1617179Beta-ketoacyl reductase By similarity

Sites

Active site2071For beta-ketoacyl synthase activity By similarity
Active site6541For malonyltransferase activity By similarity

Amino acid modifications

Modified residue17451O-(pantetheine 4'-phosphoryl)serine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TXL7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3081356D90C3FE71

FASTA1,827193,238
        10         20         30         40         50         60 
MTSLAERAAQ LSPNARAALA RELVRAGTTF PTDICEPVAV VGIGCRFPGN VTGPESFWQL 

        70         80         90        100        110        120 
LADGVDTIEQ VPPDRWDADA FYDPDPSASG RMTTKWGGFV SDVDAFDADF FGITPREAVA 

       130        140        150        160        170        180 
MDPQHRILLE VAWEALEHAG IPPDSLSGTR TGVMMGLSSW DYTIVNIERR ADIDAYLSTG 

       190        200        210        220        230        240 
TPHCAAVGRI AYLLGLRGPA VAVDTACSSS LVAIHLACQS LRLRETDVAL AGGVQLTLSP 

       250        260        270        280        290        300 
FTAIALSKWS ALSPTGRCNS FDANADGFVR GEGCGVVVLK RLADAVRDQD RVLAVVRGSA 

       310        320        330        340        350        360 
TNSDGRSNGM TAPNALAQRD VITSALKLAD VTPDSVNYVE THGTGTVLGD PIEFESLAAT 

       370        380        390        400        410        420 
YGLGKGQGES PCALGSVKTN IGHLEAAAGV AGFIKAVLAV QRGHIPRNLH FTRWNPAIDA 

       430        440        450        460        470        480 
SATRLFVPTE SAPWPAAAGP RRAAVSSFGL SGTNAHVVVE QAPDTAVAAA GGMPYVSALN 

       490        500        510        520        530        540 
VSGKTAARVA SAAAVLADWM SGPGAAAPLA DVAHTLNRHR ARHAKFATVI ARDRAEAIAG 

       550        560        570        580        590        600 
LRALAAGQPR VGVVDCDQHA GGPGRVFVYS GQGSQWASMG QQLLANEPAF AKAVAELDPI 

       610        620        630        640        650        660 
FVDQVGFSLQ QTLIDGDEVV GIDRIQPVLV GMQLALTELW RSYGVIPDAV IGHSMGEVSA 

       670        680        690        700        710        720 
AVVAGALTPE QGLRVITTRS RLMARLSGQG AMALLELDAD AAEALIAGYP QVTLAVHASP 

       730        740        750        760        770        780 
RQTVIAGPPE QVDTVIAAVA TQNRLARRVE VDVASHHPII DPILPELRSA LADLTPQPPS 

       790        800        810        820        830        840 
IPIISTTYES AQPVADADYW SANLRNPVRF HQAVTAAGVD HNTFIEISPH PVLTHALTDT 

       850        860        870        880        890        900 
LDPDGSHTVM STMNRELDQT LYFHAQLAAV GVAASEHTTG RLVDLPPTPW HHQRFWVTDR 

       910        920        930        940        950        960 
SAMSELAATH PLLGAHIEMP RNGDHVWQTD VGTEVCPWLA DHKVFGQPIM PAAGFAEIAL 

       970        980        990       1000       1010       1020 
AAASEALGTA ADAVAPNIVI NQFEVEQMLP LDGHTPLTTQ LIRGGDSQIR VEIYSRTRGG 

      1030       1040       1050       1060       1070       1080 
EFCRHATAKV EQSPRECAHA HPEAQGPATG TTVSPADFYA LLRQTGQHHG PAFAALSRIV 

      1090       1100       1110       1120       1130       1140 
RLADGSAETE ISIPDEAPRH PGYRLHPVVL DAALQSVGAA IPDGEIAGSA EASYLPVSFE 

      1150       1160       1170       1180       1190       1200 
TIRVYRDIGR HVRCRAHLTN LDGGTGKMGR IVLINDAGHI AAEVDGIYLR RVERRAVPLP 

      1210       1220       1230       1240       1250       1260 
LEQKIFDAEW TESPIAAVPA PEPAAETTRG SWLVLADATV DAPGKAQAKS MADDFVQQWR 

      1270       1280       1290       1300       1310       1320 
SPMRRVHTAD IHDESAVLAA FAETAGDPEH PPVGVVVFVG GASSRLDDEL AAARDTVWSI 

      1330       1340       1350       1360       1370       1380 
TTVVRAVVGT WHGRSPRLWL VTGGGLSVAD DEPGTPAAAS LKGLVRVLAF EHPDMRTTLV 

      1390       1400       1410       1420       1430       1440 
DLDITQDPLT ALSAELRNAG SGSRHDDVIA WRGERRFVER LSRATIDVSK GHPVVRQGAS 

      1450       1460       1470       1480       1490       1500 
YVVTGGLGGL GLVVARWLVD RGAGRVVLGG RSDPTDEQCN VLAELQTRAE IVVVRGDVAS 

      1510       1520       1530       1540       1550       1560 
PGVAEKLIET ARQSGGQLRG VVHAAAVIED SLVFSMSRDN LERVWAPKAT GALRMHEATA 

      1570       1580       1590       1600       1610       1620 
DCELDWWLGF SSAASLLGSP GQAAYACASA WLDALVGWRR ASGLPAAVIN WGPWSEVGVA 

      1630       1640       1650       1660       1670       1680 
QALVGSVLDT ISVAEGIEAL DSLLAADRIR TGVARLRADR ALVAFPEIRS ISYFTQVVEE 

      1690       1700       1710       1720       1730       1740 
LDSAGDLGDW GGPDALADLD PGEARRAVTE RMCARIAAVM GYTDQSTVEP AVPLDKPLTE 

      1750       1760       1770       1780       1790       1800 
LGLDSLMAVR IRNGARADFG VEPPVALILQ GASLHDLTAD LMRQLGLNDP DPALNNADTI 

      1810       1820 
RDRARQRAAA RHGAAMRRRP KPAVQGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248344 Genomic DNA. Translation: CAD96646.1.
RefSeqNP_856604.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TXL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2959.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD96646; CAD96646; Mb2959.
GeneID1092147.
KEGGmbo:Mb2959.
PATRIC18008230. VBIMycBov88188_3247.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3321.
HOGENOMHOG000046292.
KOK12443.
OMACARTHAE.
OrthoDBEOG6QP0WP.
ProtClustDBCLSK792172.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTSM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMSSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPSD_MYCBO
AccessionPrimary (citable) accession number: Q7TXL7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways