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Q7TXL7

- PPSD_MYCBO

UniProt

Q7TXL7 - PPSD_MYCBO

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Protein

Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD

Gene

ppsD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives, respectively.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein].PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071For beta-ketoacyl synthase activityPROSITE-ProRule annotation
Active sitei654 – 6541For malonyltransferase activityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1440 – 148546NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: UniProtKB-KW
  3. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  3. phenolic phthiocerol biosynthetic process Source: UniProtKB
  4. phthiocerol biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD
Alternative name(s):
Beta-ketoacyl-acyl-carrier-protein synthase I (EC:2.3.1.41)
Gene namesi
Name:ppsD
Ordered Locus Names:Mb2959
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. polyketide synthase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18271827Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsDPRO_0000406949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1745 – 17451O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2959.

Structurei

3D structure databases

ProteinModelPortaliQ7TXL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1708 – 178275Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 464427Beta-ketoacyl synthaseBy similarityAdd
BLAST
Regioni566 – 876311AcyltransferaseBy similarityAdd
BLAST
Regioni910 – 1076167DehydrataseBy similarityAdd
BLAST
Regioni1439 – 1617179Beta-ketoacyl reductaseBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3321.
HOGENOMiHOG000046292.
KOiK12443.
OMAiCARTHAE.
OrthoDBiEOG6QP0WP.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TXL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLAERAAQ LSPNARAALA RELVRAGTTF PTDICEPVAV VGIGCRFPGN
60 70 80 90 100
VTGPESFWQL LADGVDTIEQ VPPDRWDADA FYDPDPSASG RMTTKWGGFV
110 120 130 140 150
SDVDAFDADF FGITPREAVA MDPQHRILLE VAWEALEHAG IPPDSLSGTR
160 170 180 190 200
TGVMMGLSSW DYTIVNIERR ADIDAYLSTG TPHCAAVGRI AYLLGLRGPA
210 220 230 240 250
VAVDTACSSS LVAIHLACQS LRLRETDVAL AGGVQLTLSP FTAIALSKWS
260 270 280 290 300
ALSPTGRCNS FDANADGFVR GEGCGVVVLK RLADAVRDQD RVLAVVRGSA
310 320 330 340 350
TNSDGRSNGM TAPNALAQRD VITSALKLAD VTPDSVNYVE THGTGTVLGD
360 370 380 390 400
PIEFESLAAT YGLGKGQGES PCALGSVKTN IGHLEAAAGV AGFIKAVLAV
410 420 430 440 450
QRGHIPRNLH FTRWNPAIDA SATRLFVPTE SAPWPAAAGP RRAAVSSFGL
460 470 480 490 500
SGTNAHVVVE QAPDTAVAAA GGMPYVSALN VSGKTAARVA SAAAVLADWM
510 520 530 540 550
SGPGAAAPLA DVAHTLNRHR ARHAKFATVI ARDRAEAIAG LRALAAGQPR
560 570 580 590 600
VGVVDCDQHA GGPGRVFVYS GQGSQWASMG QQLLANEPAF AKAVAELDPI
610 620 630 640 650
FVDQVGFSLQ QTLIDGDEVV GIDRIQPVLV GMQLALTELW RSYGVIPDAV
660 670 680 690 700
IGHSMGEVSA AVVAGALTPE QGLRVITTRS RLMARLSGQG AMALLELDAD
710 720 730 740 750
AAEALIAGYP QVTLAVHASP RQTVIAGPPE QVDTVIAAVA TQNRLARRVE
760 770 780 790 800
VDVASHHPII DPILPELRSA LADLTPQPPS IPIISTTYES AQPVADADYW
810 820 830 840 850
SANLRNPVRF HQAVTAAGVD HNTFIEISPH PVLTHALTDT LDPDGSHTVM
860 870 880 890 900
STMNRELDQT LYFHAQLAAV GVAASEHTTG RLVDLPPTPW HHQRFWVTDR
910 920 930 940 950
SAMSELAATH PLLGAHIEMP RNGDHVWQTD VGTEVCPWLA DHKVFGQPIM
960 970 980 990 1000
PAAGFAEIAL AAASEALGTA ADAVAPNIVI NQFEVEQMLP LDGHTPLTTQ
1010 1020 1030 1040 1050
LIRGGDSQIR VEIYSRTRGG EFCRHATAKV EQSPRECAHA HPEAQGPATG
1060 1070 1080 1090 1100
TTVSPADFYA LLRQTGQHHG PAFAALSRIV RLADGSAETE ISIPDEAPRH
1110 1120 1130 1140 1150
PGYRLHPVVL DAALQSVGAA IPDGEIAGSA EASYLPVSFE TIRVYRDIGR
1160 1170 1180 1190 1200
HVRCRAHLTN LDGGTGKMGR IVLINDAGHI AAEVDGIYLR RVERRAVPLP
1210 1220 1230 1240 1250
LEQKIFDAEW TESPIAAVPA PEPAAETTRG SWLVLADATV DAPGKAQAKS
1260 1270 1280 1290 1300
MADDFVQQWR SPMRRVHTAD IHDESAVLAA FAETAGDPEH PPVGVVVFVG
1310 1320 1330 1340 1350
GASSRLDDEL AAARDTVWSI TTVVRAVVGT WHGRSPRLWL VTGGGLSVAD
1360 1370 1380 1390 1400
DEPGTPAAAS LKGLVRVLAF EHPDMRTTLV DLDITQDPLT ALSAELRNAG
1410 1420 1430 1440 1450
SGSRHDDVIA WRGERRFVER LSRATIDVSK GHPVVRQGAS YVVTGGLGGL
1460 1470 1480 1490 1500
GLVVARWLVD RGAGRVVLGG RSDPTDEQCN VLAELQTRAE IVVVRGDVAS
1510 1520 1530 1540 1550
PGVAEKLIET ARQSGGQLRG VVHAAAVIED SLVFSMSRDN LERVWAPKAT
1560 1570 1580 1590 1600
GALRMHEATA DCELDWWLGF SSAASLLGSP GQAAYACASA WLDALVGWRR
1610 1620 1630 1640 1650
ASGLPAAVIN WGPWSEVGVA QALVGSVLDT ISVAEGIEAL DSLLAADRIR
1660 1670 1680 1690 1700
TGVARLRADR ALVAFPEIRS ISYFTQVVEE LDSAGDLGDW GGPDALADLD
1710 1720 1730 1740 1750
PGEARRAVTE RMCARIAAVM GYTDQSTVEP AVPLDKPLTE LGLDSLMAVR
1760 1770 1780 1790 1800
IRNGARADFG VEPPVALILQ GASLHDLTAD LMRQLGLNDP DPALNNADTI
1810 1820
RDRARQRAAA RHGAAMRRRP KPAVQGG
Length:1,827
Mass (Da):193,238
Last modified:October 1, 2003 - v1
Checksum:i3081356D90C3FE71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44226.1.
RefSeqiNP_856604.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96646; CAD96646; Mb2959.
GeneIDi1092147.
KEGGimbo:Mb2959.
PATRICi18008230. VBIMycBov88188_3247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44226.1 .
RefSeqi NP_856604.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TXL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96646 ; CAD96646 ; Mb2959 .
GeneIDi 1092147.
KEGGi mbo:Mb2959.
PATRICi 18008230. VBIMycBov88188_3247.

Phylogenomic databases

eggNOGi COG3321.
HOGENOMi HOG000046292.
KOi K12443.
OMAi CARTHAE.
OrthoDBi EOG6QP0WP.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
SMARTi SM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPPSD_MYCBO
AccessioniPrimary (citable) accession number: Q7TXL7
Secondary accession number(s): X2BMU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3