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Q7TXH9 (DDL_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:Mb3005c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177841

Regions

Domain153 – 360208ATP-grasp
Nucleotide binding181 – 23656ATP By similarity

Sites

Metal binding3151Magnesium or manganese 1 By similarity
Metal binding3271Magnesium or manganese 1 By similarity
Metal binding3271Magnesium or manganese 2 By similarity
Metal binding3291Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TXH9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2A977B1ACCB4DB53

FASTA37039,253
        10         20         30         40         50         60 
MSANDRRVRV AVVFGGRSNE HAISCVSAGS ILRNLDSRRF DVIAVGITPA GSWVLTDANP 

        70         80         90        100        110        120 
DALTITNREL PQVKSGSGTE LALPADPRRG GQLVSLPPGA GEVLESVDVV FPVLHGPYGE 

       130        140        150        160        170        180 
DGTIQGLLEL AGVPYVGAGV LASAVGMDKE FTKKLLAADG LPVGAYAVLR PPRSTLHRQE 

       190        200        210        220        230        240 
CERLGLPVFV KPARGGSSIG VSRVSSWDQL PAAVARARRH DPKVIVEAAI SGRELECGVL 

       250        260        270        280        290        300 
EMPDGTLEAS TLGEIRVAGV RGREDSFYDF ATKYLDDAAE LDVPAKVDDQ VAEAIRQLAI 

       310        320        330        340        350        360 
RAFAAIDCRG LARVDFFLTD DGPVINEINT MPGFTTISMY PRMWAASGVD YPTLLATMIE 

       370 
TALARGVGLH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248344 Genomic DNA. Translation: CAD96692.1.
RefSeqNP_856650.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TXH9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3005c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD96692; CAD96692; Mb3005c.
GeneID1093577.
KEGGmbo:Mb3005c.
PATRIC18008344. VBIMycBov88188_3304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_MYCBO
AccessionPrimary (citable) accession number: Q7TXH9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways