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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3158-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:BQ2027_MB3007
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986871 – 2142-phospho-L-lactate guanylyltransferaseAdd BLAST214

Structurei

3D structure databases

ProteinModelPortaliQ7TXH8
SMRiQ7TXH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
OMAiAMLVDTI

Family and domain databases

Gene3Di3.90.550.101 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TXH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTPDDGDI GLIIAVKRLA AAKTRLAPVF SAQTRENVVL AMLVDTLTAA
60 70 80 90 100
AGVGSLRSIT VITPDEAAAA AAAGLGADVL ADPTPEDDPD PLNTAITAAE
110 120 130 140 150
RVVAEGASNI VVLQGDLPAL QTQELAEAIS AARHHRRSFV ADRLGTGTAV
160 170 180 190 200
LCAFGTALHP RFGPDSSARH RRSGAVELTG AWPGLRCDVD TPADLTAARQ
210
LGVGPATARA VAHR
Length:214
Mass (Da):21,819
Last modified:October 1, 2003 - v1
Checksum:i207508F4E007629E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU01631.1
RefSeqiNP_856652.1, NC_002945.3
WP_003415094.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44275; CDO44275; Mb3007
PATRICifig|233413.5.peg.3306

Similar proteinsi

Entry informationi

Entry nameiCOFC_MYCBO
AccessioniPrimary (citable) accession number: Q7TXH8
Secondary accession number(s): A0A1R3Y2S2, X2BMR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome