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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Charge relay systemUniRule annotation1
Active sitei156Charge relay systemUniRule annotation1
Active sitei180Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-ADT subunit AUniRule annotation
Gene namesi
Name:gatAUniRule annotation
Ordered Locus Names:BQ2027_MB3036C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001051771 – 494Glutamyl-tRNA(Gln) amidotransferase subunit AAdd BLAST494

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7TXG2.
SMRiQ7TXG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000116699.
KOiK02433.
OMAiPITQNVE.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA. 1 hit.
InterProiView protein in InterPro
IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR036928. AS_sf.
IPR004412. GatA.
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiView protein in Pfam
PF01425. Amidase. 1 hit.
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
PROSITEiView protein in PROSITE
PS00571. AMIDASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIIRSDAA TLAAKIAIKE VSSTEITRAC LDQIEATDET YHAFLHVAAD
60 70 80 90 100
EALAAAAAVD KQVAAGEPLP SALAGVPLAL KDVFTTSDMP TTCGSKILEG
110 120 130 140 150
WRSPYDATLT ARLRAAGIPI LGKTNMDEFA MGSSTENSAY GPTRNPWNLD
160 170 180 190 200
RVPGGSGGGS AAALAAFQAP LAIGSDTGGS IRQPAALTAT VGVKPTYGTV
210 220 230 240 250
SRYGLVACAS SLDQGGPCAR TVLDTALLHQ VIAGHDPRDS TSVDAEVPDV
260 270 280 290 300
VGAARAGAVG DLRGVRVGVV RQLHGGEGYQ PGVLASFEAA VEQLTALGAE
310 320 330 340 350
VSEVDCPHFD HALAAYYLIL PSEVSSNLAR FDAMRYGLRV GDDGTRSAEE
360 370 380 390 400
VMAMTRAAGF GPEVKRRIMI GTYALSAGYY DAYYNQAQKV RTLIARDLDA
410 420 430 440 450
AYRSVDVLVS PTTPTTAFRL GEKVDDPLAM YLFDLCTLPL NLAGHCGMSV
460 470 480 490
PSGLSPDDGL PVGLQIMAPA LADDRLYRVG AAYEAARGPL LSAI
Length:494
Mass (Da):51,436
Last modified:October 1, 2003 - v1
Checksum:iFE9F74EAAE74CE4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU01660.1.
RefSeqiNP_856681.1. NC_002945.3.
WP_010950812.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO44304; CDO44304; Mb3036c.
KEGGimbo:Mb3036c.
PATRICifig|233413.5.peg.3336.

Similar proteinsi

Entry informationi

Entry nameiGATA_MYCBO
AccessioniPrimary (citable) accession number: Q7TXG2
Secondary accession number(s): A0A1R3Y2V8, X2BMB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families