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Q7TXA9

- PKNK_MYCBO

UniProt

Q7TXA9 - PKNK_MYCBO

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Protein

Serine/threonine-protein kinase PknK

Gene

pknK

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATPPROSITE-ProRule annotation
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation
Metal bindingi154 – 1541MagnesiumBy similarity
Metal bindingi167 – 1671MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 409ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknK (EC:2.7.11.1)
Alternative name(s):
Protein kinase K
Gene namesi
Name:pknK
Ordered Locus Names:Mb3107c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11101110Serine/threonine-protein kinase PknKPRO_0000171223Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3107c.

Structurei

3D structure databases

ProteinModelPortaliQ7TXA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 283258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000074403.
KOiK13419.
OMAiGPLWRRS.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TXA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVDPHATR RDLVPNIPAE LLEAGFDNVE EIGRGGFGVV YRCVQPSLDR
60 70 80 90 100
AVAVKVLSTD LDRDNLERFL REQRAMGRLS GHPHIVTVLQ VGVLAGGRPF
110 120 130 140 150
IVMPYHAKNS LETLIRRHGP LDWRETLSIG VKLAGALEAA HRVGTLHRDV
160 170 180 190 200
KPGNILLTDY GEPQLTDFGI ARIAGGFETA TGVIAGSPAF TAPEVLEGAS
210 220 230 240 250
PTPASDVYSL GATLFCVLTG HAAYERRSGE RVIAQFLRIT SQPIPDLRKQ
260 270 280 290 300
GLPADVAAAI ERAMARHPAD RPATAADVGE ELRDVQRRNG VSVDEMPLPV
310 320 330 340 350
ELGVERRRSP EAHAAHRHTG GGTPTVPTPP TPATKYRPSV PTGSLVTRSR
360 370 380 390 400
LTDILRAGGR RRLILIHAPS GFGKSTLAAQ WREELSRDGA AVAWLTIDND
410 420 430 440 450
DNNEVWFLSH LLESIRRVRP TLAESLGHVL EEHGDDAGRY VLTSLIDEIH
460 470 480 490 500
ENDDRIAVVI DDWHRVSDSR TQAALGFLLD NGCHHLQLIV TSWSRAGLPV
510 520 530 540 550
GRLRIGDELA EIDSAALRFD TDEAAALLND AGGLRLPRAD VQALTTSTDG
560 570 580 590 600
WAAALRLAAL SLRGGGDATQ LLRGLSGASD VIHEFLSENV LDTLEPELRE
610 620 630 640 650
FLLVASVTER TCGGLASALA GITNGRAMLE EAEHRGLFLQ RTEDDPNWFR
660 670 680 690 700
FHQMFADFLH RRLERGGSHR VAELHRRASA WFAENGYLHE AVDHALAAGD
710 720 730 740 750
PARAVDLVEQ DETNLPEQSK MTTLLAIVQK LPTSMVVSRA RLQLAIAWAN
760 770 780 790 800
ILLQRPAPAT GALNRFETAL GRAELPEATQ ADLRAEADVL RAVAEVFADR
810 820 830 840 850
VERVDDLLAE AMSRPDTLPP RVPGTAGNTA ALAAICRFEF AEVYPLLDWA
860 870 880 890 900
APYQEMMGPF GTVYAQCLRG MAARNRLDIV AALQNFRTAF EVGTAVGAHS
910 920 930 940 950
HAARLAGSLL AELLYETGDL AGAGRLMDES YLLGSEGGAV DYLAARYVIG
960 970 980 990 1000
ARVKAAQGDH EGAADRLSTG GDTAVQLGLP RLAARINNER IRLGIALPAA
1010 1020 1030 1040 1050
VAADLLAPRT IPRDNGIATM TAELDEDSAV RLLSAGDSAD RDQACQRAGA
1060 1070 1080 1090 1100
LAAAIDGTRR PLAALQAQIL HIETLAATGR ESDARNELAP VATKCAELGL
1110
SRLLVDAGLA
Length:1,110
Mass (Da):119,446
Last modified:October 1, 2003 - v1
Checksum:i3C2AD79972BCCDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1.
RefSeqiNP_856752.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96794; CAD96794; Mb3107c.
GeneIDi1093286.
KEGGimbo:Mb3107c.
PATRICi18008570. VBIMycBov88188_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1 .
RefSeqi NP_856752.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TXA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3107c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96794 ; CAD96794 ; Mb3107c .
GeneIDi 1093286.
KEGGi mbo:Mb3107c.
PATRICi 18008570. VBIMycBov88188_3414.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000074403.
KOi K13419.
OMAi GPLWRRS.
OrthoDBi EOG69GZGV.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNK_MYCBO
AccessioniPrimary (citable) accession number: Q7TXA9
Secondary accession number(s): X2BNB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3