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Protein

Serine/threonine-protein kinase PknK

Gene

pknK

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei148Proton acceptorPROSITE-ProRule annotation1
Metal bindingi154MagnesiumBy similarity1
Metal bindingi167MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknK (EC:2.7.11.1)
Alternative name(s):
Protein kinase K
Gene namesi
Name:pknK
Ordered Locus Names:Mb3107c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712231 – 1110Serine/threonine-protein kinase PknKAdd BLAST1110

Structurei

3D structure databases

ProteinModelPortaliQ7TXA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 283Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000074403.
KOiK13419.
OMAiFIIAQCH.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TXA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVDPHATR RDLVPNIPAE LLEAGFDNVE EIGRGGFGVV YRCVQPSLDR
60 70 80 90 100
AVAVKVLSTD LDRDNLERFL REQRAMGRLS GHPHIVTVLQ VGVLAGGRPF
110 120 130 140 150
IVMPYHAKNS LETLIRRHGP LDWRETLSIG VKLAGALEAA HRVGTLHRDV
160 170 180 190 200
KPGNILLTDY GEPQLTDFGI ARIAGGFETA TGVIAGSPAF TAPEVLEGAS
210 220 230 240 250
PTPASDVYSL GATLFCVLTG HAAYERRSGE RVIAQFLRIT SQPIPDLRKQ
260 270 280 290 300
GLPADVAAAI ERAMARHPAD RPATAADVGE ELRDVQRRNG VSVDEMPLPV
310 320 330 340 350
ELGVERRRSP EAHAAHRHTG GGTPTVPTPP TPATKYRPSV PTGSLVTRSR
360 370 380 390 400
LTDILRAGGR RRLILIHAPS GFGKSTLAAQ WREELSRDGA AVAWLTIDND
410 420 430 440 450
DNNEVWFLSH LLESIRRVRP TLAESLGHVL EEHGDDAGRY VLTSLIDEIH
460 470 480 490 500
ENDDRIAVVI DDWHRVSDSR TQAALGFLLD NGCHHLQLIV TSWSRAGLPV
510 520 530 540 550
GRLRIGDELA EIDSAALRFD TDEAAALLND AGGLRLPRAD VQALTTSTDG
560 570 580 590 600
WAAALRLAAL SLRGGGDATQ LLRGLSGASD VIHEFLSENV LDTLEPELRE
610 620 630 640 650
FLLVASVTER TCGGLASALA GITNGRAMLE EAEHRGLFLQ RTEDDPNWFR
660 670 680 690 700
FHQMFADFLH RRLERGGSHR VAELHRRASA WFAENGYLHE AVDHALAAGD
710 720 730 740 750
PARAVDLVEQ DETNLPEQSK MTTLLAIVQK LPTSMVVSRA RLQLAIAWAN
760 770 780 790 800
ILLQRPAPAT GALNRFETAL GRAELPEATQ ADLRAEADVL RAVAEVFADR
810 820 830 840 850
VERVDDLLAE AMSRPDTLPP RVPGTAGNTA ALAAICRFEF AEVYPLLDWA
860 870 880 890 900
APYQEMMGPF GTVYAQCLRG MAARNRLDIV AALQNFRTAF EVGTAVGAHS
910 920 930 940 950
HAARLAGSLL AELLYETGDL AGAGRLMDES YLLGSEGGAV DYLAARYVIG
960 970 980 990 1000
ARVKAAQGDH EGAADRLSTG GDTAVQLGLP RLAARINNER IRLGIALPAA
1010 1020 1030 1040 1050
VAADLLAPRT IPRDNGIATM TAELDEDSAV RLLSAGDSAD RDQACQRAGA
1060 1070 1080 1090 1100
LAAAIDGTRR PLAALQAQIL HIETLAATGR ESDARNELAP VATKCAELGL
1110
SRLLVDAGLA
Length:1,110
Mass (Da):119,446
Last modified:October 1, 2003 - v1
Checksum:i3C2AD79972BCCDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1.
RefSeqiNP_856752.1. NC_002945.3.
WP_003416064.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44376; CDO44376; Mb3107c.
GeneIDi1093286.
KEGGimbo:Mb3107c.
PATRICi18008570. VBIMycBov88188_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1.
RefSeqiNP_856752.1. NC_002945.3.
WP_003416064.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TXA9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44376; CDO44376; Mb3107c.
GeneIDi1093286.
KEGGimbo:Mb3107c.
PATRICi18008570. VBIMycBov88188_3414.

Phylogenomic databases

HOGENOMiHOG000074403.
KOiK13419.
OMAiFIIAQCH.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNK_MYCBO
AccessioniPrimary (citable) accession number: Q7TXA9
Secondary accession number(s): X2BNB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.