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Q7TXA9

- PKNK_MYCBO

UniProt

Q7TXA9 - PKNK_MYCBO

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Protein

Serine/threonine-protein kinase PknK

Gene
pknK, Mb3107c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATP By similarity
Active sitei148 – 1481Proton acceptor By similarity
Metal bindingi154 – 1541Magnesium By similarity
Metal bindingi167 – 1671Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 409ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknK (EC:2.7.11.1)
Alternative name(s):
Protein kinase K
Gene namesi
Name:pknK
Ordered Locus Names:Mb3107c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11101110Serine/threonine-protein kinase PknKPRO_0000171223Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3107c.

Structurei

3D structure databases

ProteinModelPortaliQ7TXA9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 283258Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000074403.
KOiK13419.
OMAiGPLWRRS.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TXA9-1 [UniParc]FASTAAdd to Basket

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MTDVDPHATR RDLVPNIPAE LLEAGFDNVE EIGRGGFGVV YRCVQPSLDR     50
AVAVKVLSTD LDRDNLERFL REQRAMGRLS GHPHIVTVLQ VGVLAGGRPF 100
IVMPYHAKNS LETLIRRHGP LDWRETLSIG VKLAGALEAA HRVGTLHRDV 150
KPGNILLTDY GEPQLTDFGI ARIAGGFETA TGVIAGSPAF TAPEVLEGAS 200
PTPASDVYSL GATLFCVLTG HAAYERRSGE RVIAQFLRIT SQPIPDLRKQ 250
GLPADVAAAI ERAMARHPAD RPATAADVGE ELRDVQRRNG VSVDEMPLPV 300
ELGVERRRSP EAHAAHRHTG GGTPTVPTPP TPATKYRPSV PTGSLVTRSR 350
LTDILRAGGR RRLILIHAPS GFGKSTLAAQ WREELSRDGA AVAWLTIDND 400
DNNEVWFLSH LLESIRRVRP TLAESLGHVL EEHGDDAGRY VLTSLIDEIH 450
ENDDRIAVVI DDWHRVSDSR TQAALGFLLD NGCHHLQLIV TSWSRAGLPV 500
GRLRIGDELA EIDSAALRFD TDEAAALLND AGGLRLPRAD VQALTTSTDG 550
WAAALRLAAL SLRGGGDATQ LLRGLSGASD VIHEFLSENV LDTLEPELRE 600
FLLVASVTER TCGGLASALA GITNGRAMLE EAEHRGLFLQ RTEDDPNWFR 650
FHQMFADFLH RRLERGGSHR VAELHRRASA WFAENGYLHE AVDHALAAGD 700
PARAVDLVEQ DETNLPEQSK MTTLLAIVQK LPTSMVVSRA RLQLAIAWAN 750
ILLQRPAPAT GALNRFETAL GRAELPEATQ ADLRAEADVL RAVAEVFADR 800
VERVDDLLAE AMSRPDTLPP RVPGTAGNTA ALAAICRFEF AEVYPLLDWA 850
APYQEMMGPF GTVYAQCLRG MAARNRLDIV AALQNFRTAF EVGTAVGAHS 900
HAARLAGSLL AELLYETGDL AGAGRLMDES YLLGSEGGAV DYLAARYVIG 950
ARVKAAQGDH EGAADRLSTG GDTAVQLGLP RLAARINNER IRLGIALPAA 1000
VAADLLAPRT IPRDNGIATM TAELDEDSAV RLLSAGDSAD RDQACQRAGA 1050
LAAAIDGTRR PLAALQAQIL HIETLAATGR ESDARNELAP VATKCAELGL 1100
SRLLVDAGLA 1110
Length:1,110
Mass (Da):119,446
Last modified:October 1, 2003 - v1
Checksum:i3C2AD79972BCCDA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1.
RefSeqiNP_856752.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96794; CAD96794; Mb3107c.
GeneIDi1093286.
KEGGimbo:Mb3107c.
PATRICi18008570. VBIMycBov88188_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44376.1 .
RefSeqi NP_856752.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TXA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3107c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96794 ; CAD96794 ; Mb3107c .
GeneIDi 1093286.
KEGGi mbo:Mb3107c.
PATRICi 18008570. VBIMycBov88188_3414.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000074403.
KOi K13419.
OMAi GPLWRRS.
OrthoDBi EOG69GZGV.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016236. Ser/Thr_kinase_PknK_prd.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000574. Ser/Thr_PK_PknK_prd. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNK_MYCBO
AccessioniPrimary (citable) accession number: Q7TXA9
Secondary accession number(s): X2BNB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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