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Q7TWC5

- FAC17_MYCBO

UniProt

Q7TWC5 - FAC17_MYCBO

Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
    Short name:
    FACL
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD17
    Ordered Locus Names:Mb3536
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406788Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb3536.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TWC5.
    SMRiQ7TWC5. Positions 42-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000052047.
    KOiK00666.
    OMAiNTHKEMA.
    OrthoDBiEOG6VF30G.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TWC5-1 [UniParc]FASTAAdd to Basket

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    MTPTHPTVTE LLLPLSEIDD RGVYFEDSFT SWRDHIRHGA AIAAALRERL    50
    DPARPPHVGV LLQNTPFFSA TLVAGALSGI VPVGLNPVRR GAALAGDIAK 100
    ADCQLVLTGS GSAEVPADVE HINVDSPEWT DEVAAHRDTE VRFRSADLAD 150
    LFMLIFTSGT SGDPKAVKCS HRKVAIAGVT ITQRFSLGRD DVCYVSMPLF 200
    HSNAVLVGWA VAAACQGSMA LRRKFSASQF LADVRRYGAT YANYVGKPLS 250
    YVLATPELPD DADNPLRAVY GNEGVPGDID RFGRRFGCVV MDGFGSTEGG 300
    VAITRTLDTP AGALGPLPGG IQIVDPDTGE PCPTGVVGEL VNTAGPGGFE 350
    GYYNDEAAEA ERMAGGVYHS GDLAYRDDAG YAYFAGRLGD WMRVDGENLG 400
    TAPIERVLMR YPDATEVAVY PVPDPVVGDQ VMAALVLAPG TKFDADKFRA 450
    FLTEQPDLGH KQWPSYVRVS AGLPRTMTFK VIKRQLSAEG VACADPVWPI 500
    RR 502
    Length:502
    Mass (Da):53,739
    Last modified:October 1, 2003 - v1
    Checksum:i0AF9A7B3B9C83A4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44806.1.
    RefSeqiNP_857175.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD95722; CAD95722; Mb3536.
    GeneIDi1093720.
    KEGGimbo:Mb3536.
    PATRICi18009494. VBIMycBov88188_3875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44806.1 .
    RefSeqi NP_857175.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TWC5.
    SMRi Q7TWC5. Positions 42-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD95722 ; CAD95722 ; Mb3536 .
    GeneIDi 1093720.
    KEGGi mbo:Mb3536.
    PATRICi 18009494. VBIMycBov88188_3875.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000052047.
    KOi K00666.
    OMAi NTHKEMA.
    OrthoDBi EOG6VF30G.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiFAC17_MYCBO
    AccessioniPrimary (citable) accession number: Q7TWC5
    Secondary accession number(s): X2BPR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3