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Q7TWC5

- FAC17_MYCBO

UniProt

Q7TWC5 - FAC17_MYCBO

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Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:Mb3536
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3536.

Structurei

3D structure databases

ProteinModelPortaliQ7TWC5.
SMRiQ7TWC5. Positions 42-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiNTHKEMA.
OrthoDBiEOG6VF30G.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TWC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPTHPTVTE LLLPLSEIDD RGVYFEDSFT SWRDHIRHGA AIAAALRERL
60 70 80 90 100
DPARPPHVGV LLQNTPFFSA TLVAGALSGI VPVGLNPVRR GAALAGDIAK
110 120 130 140 150
ADCQLVLTGS GSAEVPADVE HINVDSPEWT DEVAAHRDTE VRFRSADLAD
160 170 180 190 200
LFMLIFTSGT SGDPKAVKCS HRKVAIAGVT ITQRFSLGRD DVCYVSMPLF
210 220 230 240 250
HSNAVLVGWA VAAACQGSMA LRRKFSASQF LADVRRYGAT YANYVGKPLS
260 270 280 290 300
YVLATPELPD DADNPLRAVY GNEGVPGDID RFGRRFGCVV MDGFGSTEGG
310 320 330 340 350
VAITRTLDTP AGALGPLPGG IQIVDPDTGE PCPTGVVGEL VNTAGPGGFE
360 370 380 390 400
GYYNDEAAEA ERMAGGVYHS GDLAYRDDAG YAYFAGRLGD WMRVDGENLG
410 420 430 440 450
TAPIERVLMR YPDATEVAVY PVPDPVVGDQ VMAALVLAPG TKFDADKFRA
460 470 480 490 500
FLTEQPDLGH KQWPSYVRVS AGLPRTMTFK VIKRQLSAEG VACADPVWPI

RR
Length:502
Mass (Da):53,739
Last modified:October 1, 2003 - v1
Checksum:i0AF9A7B3B9C83A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44806.1.
RefSeqiNP_857175.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD95722; CAD95722; Mb3536.
GeneIDi1093720.
KEGGimbo:Mb3536.
PATRICi18009494. VBIMycBov88188_3875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44806.1 .
RefSeqi NP_857175.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TWC5.
SMRi Q7TWC5. Positions 42-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD95722 ; CAD95722 ; Mb3536 .
GeneIDi 1093720.
KEGGi mbo:Mb3536.
PATRICi 18009494. VBIMycBov88188_3875.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000052047.
KOi K00666.
OMAi NTHKEMA.
OrthoDBi EOG6VF30G.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC17_MYCBO
AccessioniPrimary (citable) accession number: Q7TWC5
Secondary accession number(s): X2BPR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3