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Q7TWB7

- FAC19_MYCBO

UniProt

Q7TWB7 - FAC19_MYCBO

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Protein

Long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligase

Gene

fadD19

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. Also involved in the degradation of cholesterol via the degradation of the side chains of C-24 branched-chain sterols. Catalyzes the ATP-dependent CoA thioesterification of the sterol 3-oxocholest-4-en-26-oate to yield 3-oxocholest-4-en-26-oyl-CoA.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.By similarity
ATP + 3-oxocholest-4-en-26-oate + CoA = AMP + diphosphate + 3-oxocholest-4-en-26-oyl-CoA.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei415 – 4151ATPBy similarity
Binding sitei430 – 4301ATPBy similarity
Binding sitei521 – 5211ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 1829ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cholesterol metabolism, Fatty acid metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.
UPA00296.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligaseBy similarity (EC:6.2.1.3By similarity, EC:6.2.1.42By similarity)
Short name:
FACLBy similarity
Alternative name(s):
Acyl-CoA synthetaseBy similarity
Steroid-CoA ligaseBy similarity
Steroid-coenzyme A ligaseBy similarity
Gene namesi
Name:fadD19By similarity
Ordered Locus Names:Mb3544c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligasePRO_0000406791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3544c.

Structurei

3D structure databases

ProteinModelPortaliQ7TWB7.
SMRiQ7TWB7. Positions 12-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000230015.
KOiK00666.
OMAiYRYVENE.
OrthoDBiEOG6MSRZN.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TWB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVALNIADL AEHAIDAVPD RVAVICGDEQ LTYAQLEDKA NRLAHHLIDQ
60 70 80 90 100
GVQKDDKVGL YCRNRIEIVI AMLGIVKAGA ILVNVNFRYV EGELRYLFDN
110 120 130 140 150
SDMVALVHER RYADRVANVL PDTPHVRTIL VVEDGSDQDY RRYGGVEFYS
160 170 180 190 200
AIAAGSPERD FGERSADAIY LLYTGGTTGF PKGVMWRHED IYRVLFGGTD
210 220 230 240 250
FATGEFVKDE YDLAKAAAAN PPMIRYPIPP MIHGATQSAT WMALFSGQTT
260 270 280 290 300
VLAPEFNADE VWRTIHKHKV NLLFFTGDAM ARPLVDALVK GNDYDLSSLF
310 320 330 340 350
LLASTAALFS PSIKEKLLEL LPNRVITDSI GSSETGFGGT SVVAAGQAHG
360 370 380 390 400
GGPRVRIDHR TVVLDDDGNE VKPGSGMRGV IAKKGNIPVG YYKDEKKTAE
410 420 430 440 450
TFRTINGVRY AIPGDYAQVE EDGTVTMLGR GSVSINSGGE KVYPEEVEAA
460 470 480 490 500
LKGHPDVFDA LVVGVPDPRY GQQVAAVVQA RPGCRPSLAE LDSFVRSEIA
510 520 530 540
GYKVPRSLWF VDEVKRSPAG KPDYRWAKEQ TEARPADDVH AGHVTSGG
Length:548
Mass (Da):59,741
Last modified:October 1, 2003 - v1
Checksum:iE574B4BFA86F324E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44814.1.
RefSeqiNP_857183.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD95730; CAD95730; Mb3544c.
GeneIDi1093161.
KEGGimbo:Mb3544c.
PATRICi18009510. VBIMycBov88188_3883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44814.1 .
RefSeqi NP_857183.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TWB7.
SMRi Q7TWB7. Positions 12-521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3544c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD95730 ; CAD95730 ; Mb3544c .
GeneIDi 1093161.
KEGGi mbo:Mb3544c.
PATRICi 18009510. VBIMycBov88188_3883.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000230015.
KOi K00666.
OMAi YRYVENE.
OrthoDBi EOG6MSRZN.

Enzyme and pathway databases

UniPathwayi UPA00094 .
UPA00296 .

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC19_MYCBO
AccessioniPrimary (citable) accession number: Q7TWB7
Secondary accession number(s): X2BNN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3