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Q7TWB7

- FAC19_MYCBO

UniProt

Q7TWB7 - FAC19_MYCBO

Protein

Long-chain-fatty-acid--CoA ligase FadD19

Gene

fadD19

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase FadD19 (EC:6.2.1.3)
    Short name:
    FACL
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD19
    Ordered Locus Names:Mb3544c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Long-chain-fatty-acid--CoA ligase FadD19PRO_0000406791Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb3544c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TWB7.
    SMRiQ7TWB7. Positions 12-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000230015.
    KOiK00666.
    OMAiYRYVENE.
    OrthoDBiEOG6MSRZN.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TWB7-1 [UniParc]FASTAAdd to Basket

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    MAVALNIADL AEHAIDAVPD RVAVICGDEQ LTYAQLEDKA NRLAHHLIDQ    50
    GVQKDDKVGL YCRNRIEIVI AMLGIVKAGA ILVNVNFRYV EGELRYLFDN 100
    SDMVALVHER RYADRVANVL PDTPHVRTIL VVEDGSDQDY RRYGGVEFYS 150
    AIAAGSPERD FGERSADAIY LLYTGGTTGF PKGVMWRHED IYRVLFGGTD 200
    FATGEFVKDE YDLAKAAAAN PPMIRYPIPP MIHGATQSAT WMALFSGQTT 250
    VLAPEFNADE VWRTIHKHKV NLLFFTGDAM ARPLVDALVK GNDYDLSSLF 300
    LLASTAALFS PSIKEKLLEL LPNRVITDSI GSSETGFGGT SVVAAGQAHG 350
    GGPRVRIDHR TVVLDDDGNE VKPGSGMRGV IAKKGNIPVG YYKDEKKTAE 400
    TFRTINGVRY AIPGDYAQVE EDGTVTMLGR GSVSINSGGE KVYPEEVEAA 450
    LKGHPDVFDA LVVGVPDPRY GQQVAAVVQA RPGCRPSLAE LDSFVRSEIA 500
    GYKVPRSLWF VDEVKRSPAG KPDYRWAKEQ TEARPADDVH AGHVTSGG 548
    Length:548
    Mass (Da):59,741
    Last modified:October 1, 2003 - v1
    Checksum:iE574B4BFA86F324E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44814.1.
    RefSeqiNP_857183.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD95730; CAD95730; Mb3544c.
    GeneIDi1093161.
    KEGGimbo:Mb3544c.
    PATRICi18009510. VBIMycBov88188_3883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44814.1 .
    RefSeqi NP_857183.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TWB7.
    SMRi Q7TWB7. Positions 12-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3544c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD95730 ; CAD95730 ; Mb3544c .
    GeneIDi 1093161.
    KEGGi mbo:Mb3544c.
    PATRICi 18009510. VBIMycBov88188_3883.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000230015.
    KOi K00666.
    OMAi YRYVENE.
    OrthoDBi EOG6MSRZN.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiFAC19_MYCBO
    AccessioniPrimary (citable) accession number: Q7TWB7
    Secondary accession number(s): X2BNN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3