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Protein

Probable long-chain-fatty-acid--CoA ligase FadD23

Gene

fadD23

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1) (By similarity).By similarityCurated

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable long-chain-fatty-acid--CoA ligase FadD23 (EC:6.2.1.3)
Short name:
FACL ligase
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD23
Ordered Locus Names:Mb3856
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Probable long-chain-fatty-acid--CoA ligase FadD23PRO_0000406794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3856.

Structurei

3D structure databases

ProteinModelPortaliQ7TVK7.
SMRiQ7TVK7. Positions 5-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000266721.
KOiK12425.
OMAiWEVAFSG.
OrthoDBiEOG67Q968.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TVK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN
60 70 80 90 100
VAAEVRRHAA IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS
110 120 130 140 150
DERVDAVVRD AKPNVVLTTS AIMGDVVPRV TPPPGIASPP TVAVDQLDLD
160 170 180 190 200
SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG VMITYKNILA NFQQMISAYF
210 220 230 240 250
ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV LTSPVAFLQR
260 270 280 290 300
PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS
310 320 330 340 350
ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR
360 370 380 390 400
YFEPHELSAG QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI
410 420 430 440 450
GEIWVHGDNV AGGYWEKPDE TERTFGGALV APSAGTPVGP WLRTGDSGFV
460 470 480 490 500
SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT IQEITRGRCA AIAVPSNGVE
510 520 530 540 550
KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD LVLVAPGSIP
560 570 580
ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL
Length:584
Mass (Da):62,841
Last modified:September 30, 2003 - v1
Checksum:i99639AB9BEEA39EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1.
RefSeqiNP_857493.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO45128; CDO45128; Mb3856.
GeneIDi1093842.
KEGGimbo:Mb3856.
PATRICi18010195. VBIMycBov88188_4218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1.
RefSeqiNP_857493.1. NC_002945.3.

3D structure databases

ProteinModelPortaliQ7TVK7.
SMRiQ7TVK7. Positions 5-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233413.Mb3856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO45128; CDO45128; Mb3856.
GeneIDi1093842.
KEGGimbo:Mb3856.
PATRICi18010195. VBIMycBov88188_4218.

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000266721.
KOiK12425.
OMAiWEVAFSG.
OrthoDBiEOG67Q968.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC23_MYCBO
AccessioniPrimary (citable) accession number: Q7TVK7
Secondary accession number(s): X2BPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2011
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.