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Q7TVK7

- FAC23_MYCBO

UniProt

Q7TVK7 - FAC23_MYCBO

Protein

Probable long-chain-fatty-acid--CoA ligase FadD23

Gene

fadD23

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension Probable. Involved in the biosynthesis of sulfolipid 1 (SL-1) By similarity.By similarityCurated

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
    2. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable long-chain-fatty-acid--CoA ligase FadD23 (EC:6.2.1.3)
    Short name:
    FACL ligase
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD23
    Ordered Locus Names:Mb3856
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Probable long-chain-fatty-acid--CoA ligase FadD23PRO_0000406794Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb3856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TVK7.
    SMRiQ7TVK7. Positions 5-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000266721.
    KOiK12425.
    OMAiRRINSES.
    OrthoDBiEOG67Q968.

    Family and domain databases

    InterProiIPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TVK7-1 [UniParc]FASTAAdd to Basket

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    MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN    50
    VAAEVRRHAA IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS 100
    DERVDAVVRD AKPNVVLTTS AIMGDVVPRV TPPPGIASPP TVAVDQLDLD 150
    SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG VMITYKNILA NFQQMISAYF 200
    ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV LTSPVAFLQR 250
    PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS 300
    ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR 350
    YFEPHELSAG QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI 400
    GEIWVHGDNV AGGYWEKPDE TERTFGGALV APSAGTPVGP WLRTGDSGFV 450
    SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT IQEITRGRCA AIAVPSNGVE 500
    KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD LVLVAPGSIP 550
    ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL 584
    Length:584
    Mass (Da):62,841
    Last modified:October 1, 2003 - v1
    Checksum:i99639AB9BEEA39EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO45128.1.
    RefSeqiNP_857493.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96042; CAD96042; Mb3856.
    GeneIDi1093842.
    KEGGimbo:Mb3856.
    PATRICi18010195. VBIMycBov88188_4218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO45128.1 .
    RefSeqi NP_857493.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7TVK7.
    SMRi Q7TVK7. Positions 5-564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96042 ; CAD96042 ; Mb3856 .
    GeneIDi 1093842.
    KEGGi mbo:Mb3856.
    PATRICi 18010195. VBIMycBov88188_4218.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000266721.
    KOi K12425.
    OMAi RRINSES.
    OrthoDBi EOG67Q968.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    InterProi IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiFAC23_MYCBO
    AccessioniPrimary (citable) accession number: Q7TVK7
    Secondary accession number(s): X2BPQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3