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Q7TVK7 (FAC23_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable long-chain-fatty-acid--CoA ligase FadD23

Short name=FACL ligase
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD23
Ordered Locus Names:Mb3856
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension Probable. Involved in the biosynthesis of sulfolipid 1 (SL-1) By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Probable long-chain-fatty-acid--CoA ligase FadD23
PRO_0000406794

Regions

Transmembrane199 – 21921Helical; Potential
Transmembrane225 – 24521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TVK7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 99639AB9BEEA39EF

FASTA58462,841
        10         20         30         40         50         60 
MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN VAAEVRRHAA 

        70         80         90        100        110        120 
IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS DERVDAVVRD AKPNVVLTTS 

       130        140        150        160        170        180 
AIMGDVVPRV TPPPGIASPP TVAVDQLDLD SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG 

       190        200        210        220        230        240 
VMITYKNILA NFQQMISAYF ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV 

       250        260        270        280        290        300 
LTSPVAFLQR PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS 

       310        320        330        340        350        360 
ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR YFEPHELSAG 

       370        380        390        400        410        420 
QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI GEIWVHGDNV AGGYWEKPDE 

       430        440        450        460        470        480 
TERTFGGALV APSAGTPVGP WLRTGDSGFV SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT 

       490        500        510        520        530        540 
IQEITRGRCA AIAVPSNGVE KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD 

       550        560        570        580 
LVLVAPGSIP ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO45128.1.
RefSeqNP_857493.1. NC_002945.3.

3D structure databases

ProteinModelPortalQ7TVK7.
SMRQ7TVK7. Positions 5-564.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3856.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD96042; CAD96042; Mb3856.
GeneID1093842.
KEGGmbo:Mb3856.
PATRIC18010195. VBIMycBov88188_4218.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000266721.
KOK12425.
OMARRINSES.
OrthoDBEOG67Q968.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

InterProIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC23_MYCBO
AccessionPrimary (citable) accession number: Q7TVK7
Secondary accession number(s): X2BPQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways