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Q7TVK7

- FAC23_MYCBO

UniProt

Q7TVK7 - FAC23_MYCBO

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Protein

Probable long-chain-fatty-acid--CoA ligase FadD23

Gene

fadD23

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1) (By similarity).By similarityCurated

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable long-chain-fatty-acid--CoA ligase FadD23 (EC:6.2.1.3)
Short name:
FACL ligase
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD23
Ordered Locus Names:Mb3856
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Probable long-chain-fatty-acid--CoA ligase FadD23PRO_0000406794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3856.

Structurei

3D structure databases

ProteinModelPortaliQ7TVK7.
SMRiQ7TVK7. Positions 5-564.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000266721.
KOiK12425.
OMAiRRINSES.
OrthoDBiEOG67Q968.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TVK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN
60 70 80 90 100
VAAEVRRHAA IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS
110 120 130 140 150
DERVDAVVRD AKPNVVLTTS AIMGDVVPRV TPPPGIASPP TVAVDQLDLD
160 170 180 190 200
SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG VMITYKNILA NFQQMISAYF
210 220 230 240 250
ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV LTSPVAFLQR
260 270 280 290 300
PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS
310 320 330 340 350
ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR
360 370 380 390 400
YFEPHELSAG QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI
410 420 430 440 450
GEIWVHGDNV AGGYWEKPDE TERTFGGALV APSAGTPVGP WLRTGDSGFV
460 470 480 490 500
SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT IQEITRGRCA AIAVPSNGVE
510 520 530 540 550
KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD LVLVAPGSIP
560 570 580
ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL
Length:584
Mass (Da):62,841
Last modified:October 1, 2003 - v1
Checksum:i99639AB9BEEA39EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1.
RefSeqiNP_857493.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96042; CAD96042; Mb3856.
GeneIDi1093842.
KEGGimbo:Mb3856.
PATRICi18010195. VBIMycBov88188_4218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1 .
RefSeqi NP_857493.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TVK7.
SMRi Q7TVK7. Positions 5-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96042 ; CAD96042 ; Mb3856 .
GeneIDi 1093842.
KEGGi mbo:Mb3856.
PATRICi 18010195. VBIMycBov88188_4218.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000266721.
KOi K12425.
OMAi RRINSES.
OrthoDBi EOG67Q968.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

InterProi IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC23_MYCBO
AccessioniPrimary (citable) accession number: Q7TVK7
Secondary accession number(s): X2BPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3