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Q7TVK7

- FAC23_MYCBO

UniProt

Q7TVK7 - FAC23_MYCBO

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Protein
Probable long-chain-fatty-acid--CoA ligase FadD23
Gene
fadD23, Mb3856
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension Inferred. Involved in the biosynthesis of sulfolipid 1 (SL-1) By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable long-chain-fatty-acid--CoA ligase FadD23 (EC:6.2.1.3)
Short name:
FACL ligase
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD23
Ordered Locus Names:Mb3856
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei199 – 21921Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Probable long-chain-fatty-acid--CoA ligase FadD23
PRO_0000406794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3856.

Structurei

3D structure databases

ProteinModelPortaliQ7TVK7.
SMRiQ7TVK7. Positions 5-564.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000266721.
KOiK12425.
OMAiRRINSES.
OrthoDBiEOG67Q968.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TVK7-1 [UniParc]FASTAAdd to Basket

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MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN    50
VAAEVRRHAA IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS 100
DERVDAVVRD AKPNVVLTTS AIMGDVVPRV TPPPGIASPP TVAVDQLDLD 150
SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG VMITYKNILA NFQQMISAYF 200
ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV LTSPVAFLQR 250
PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS 300
ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR 350
YFEPHELSAG QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI 400
GEIWVHGDNV AGGYWEKPDE TERTFGGALV APSAGTPVGP WLRTGDSGFV 450
SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT IQEITRGRCA AIAVPSNGVE 500
KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD LVLVAPGSIP 550
ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL 584
Length:584
Mass (Da):62,841
Last modified:October 1, 2003 - v1
Checksum:i99639AB9BEEA39EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1.
RefSeqiNP_857493.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96042; CAD96042; Mb3856.
GeneIDi1093842.
KEGGimbo:Mb3856.
PATRICi18010195. VBIMycBov88188_4218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO45128.1 .
RefSeqi NP_857493.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7TVK7.
SMRi Q7TVK7. Positions 5-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96042 ; CAD96042 ; Mb3856 .
GeneIDi 1093842.
KEGGi mbo:Mb3856.
PATRICi 18010195. VBIMycBov88188_4218.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000266721.
KOi K12425.
OMAi RRINSES.
OrthoDBi EOG67Q968.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

InterProi IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiFAC23_MYCBO
AccessioniPrimary (citable) accession number: Q7TVK7
Secondary accession number(s): X2BPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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