Q7TVA4 (FBSB_PROMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase
Short name=FBPase class 2/SBPase
EC=3.1.3.11
EC=3.1.3.37

Gene names

Ordered Locus Names:

Pro_0840

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively By similarity.
Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. Sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.
Cofactor	Manganese By similarity.
Pathway	Carbohydrate biosynthesis; Calvin cycle.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the FBPase class 2 family.

Ontologies

Keywords
Biological process	Calvin cycle Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: InterPro reductive pentose-phosphate cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sedoheptulose-bisphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase		PRO_0000342713
Regions
	Region	88 – 90	3	Substrate binding By similarity
	Region	164 – 166	3	Substrate binding By similarity
	Region	186 – 188	3	Substrate binding By similarity
Sites
	Metal binding	33	1	Manganese 1 By similarity
	Metal binding	57	1	Manganese 1 By similarity
	Metal binding	85	1	Manganese 2 By similarity
	Metal binding	88	1	Manganese 2 By similarity
	Metal binding	213	1	Manganese 2 By similarity
	Binding site	119	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7TVA4 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 476812AD22A15F0C	FASTA	334	35,039
	10 20 30 40 50 60 MDRTLIQEIL EVVEQAAIAS AELTGLGQKD EADAAAVEAM RKRMGSIQMQ GRIVIGEGER 70 80 90 100 110 120 DEAPMLYIGE EVGSGSGPGV DFAVDPCEGT NLCANNQRGS MAVLAASDRG GLFNAPDFYM 130 140 150 160 170 180 KKLAAPPAAK GKVDIRKSAT ENINILSSCL GMAVSELTIV VMDRARHKDL IAEIRSTGAR 190 200 210 220 230 240 VQPISDGDVQ AAIACGFAGT GTHCLMGIGA APEGVISAAA MRALGGHFQG QLVYDPAIAM 250 260 270 280 290 300 TKEWADYTKE GNIARLNEMG ITDGDKIYEA DELASGENVV FAGSGITDGL LFNGVKFEKD 310 320 330 CTRTSSLVIS TLDSTARFTN TVHIKDGAKS ISLS

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAP99884.1.
RefSeq	NP_875232.1. NC_005042.1.
3D structure databases
HSSP	HSSP built from PDB template 1NI9 based on UniProtKB P0A9C9.
ProteinModelPortal	Q7TVA4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1462222.
GenomeReviews	Gene locus Pro_0840 in contig AE017126_GR.
KEGG	pma:Pro0840.
PATRIC	23028389. VBIProMar8617_0888.
Phylogenomic databases
HOGENOM	HBG284837.
OMA	TSEWADM.
ProtClustDB	PRK09479.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_0840-MONOMER.
Family and domain databases
InterPro	IPR004464. FBPase_class-2/SBPase. [Graphical view]
KO	K11532.
Pfam	PF03320. FBPase_glpX. 1 hit. [Graphical view]
PIRSF	PIRSF004532. GlpX. 1 hit.
TIGRFAMs	TIGR00330. GlpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FBSB_PROMA

Accession

Primary (citable) accession number: Q7TVA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program