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Q7TV01

- SYL_PROMM

UniProt

Q7TV01 - SYL_PROMM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei633 – 6331ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PMT_0715
    OrganismiProchlorococcus marinus (strain MIT 9313)
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878878Leucine--tRNA ligasePRO_0000152064Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74547.PMT0715.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TV01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi56 – 6611"HIGH" regionAdd
    BLAST
    Motifi630 – 6345"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TV01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESFPSTSA SSQSSARYDP IELETRWQKE WLRQGLDRTP VAETNQKRFY    50
    ALSMFPYPSG KLHMGHVRNY VITDVIARVQ RMRGDAVLHP MGWDAFGLPA 100
    ENAAIARNVD PGDWTDQNIA QMRAQLDRLG LSIDWDRQQA TCHQDYYRWT 150
    QWLFLELFAG GLAYQKEATV NWDPVDKTVL ANEQVDGEGR SWRSGALVEQ 200
    RQLKQWFLRI TDYADALIDD LDELTGWPER VRTMQANWIG RSHGAEIKFR 250
    VAGVANSIIT VFTTRPDTLH GASYVVLAPE HPLVESLTSP EQRLAVTAFC 300
    DLISQLSVKD RTAEDQPKRG VPIGAQVINP VNGESLPVWI ADYVLADYGS 350
    GAVMGVPAHD ERDFIFARSH ELPIRIVVQL PDTDEHHNDG QAWTGAGVLV 400
    NSGAFDGLST EEAKVAITTH GASEGWAQSK VQYRLRDWLI SRQRYWGCPI 450
    PIIHCASCGI VPVPQEDLPV TLPRDIDLSG KGGSPIAQEQ AWVEVKCPIC 500
    GEKAHRETDT MDTFMCSSWY YLRFADPLNS QRPFDKDIVD EWLPVDQYVG 550
    GIEHAILHLL YARFFTKALH DRNLIGFKEP FNRLLTQGMV QGLTYRNAKN 600
    GSYISPELVS DDSDPRDPES GDRLEVLFEK MSKSKYNGVD PAVVIDRYGA 650
    DTARMFILFK APPEKDLEWD DADVEGQFRF LQRLIRLIDS FAWPKTDGEN 700
    ASISSANLII DSADLSEEEI NMRRATHKAI EAITEDLSGD IQLNTAISEL 750
    MKLSNSLSGK LDKVRNEVAA EALSVLVRLM APFAPHLAEE FWLKLHGHGS 800
    IHQQSWPVID PSALVLETIE LVIQVKGKVR GKIQVPANAD KKTLEELALN 850
    SDIAVKWLEG QSPRRIIIVP GKLVNLVP 878
    Length:878
    Mass (Da):98,558
    Last modified:October 1, 2003 - v1
    Checksum:i344EA20A16DB279D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20890.1.
    RefSeqiNP_894547.1. NC_005071.1.
    WP_011130093.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE20890; CAE20890; PMT_0715.
    GeneIDi1729288.
    KEGGipmt:PMT0715.
    PATRICi23009405. VBIProMar135351_0857.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20890.1 .
    RefSeqi NP_894547.1. NC_005071.1.
    WP_011130093.1. NC_005071.1.

    3D structure databases

    ProteinModelPortali Q7TV01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT0715.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE20890 ; CAE20890 ; PMT_0715 .
    GeneIDi 1729288.
    KEGGi pmt:PMT0715.
    PATRICi 23009405. VBIProMar135351_0857.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313.

    Entry informationi

    Entry nameiSYL_PROMM
    AccessioniPrimary (citable) accession number: Q7TV01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3