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Q7TV01

- SYL_PROMM

UniProt

Q7TV01 - SYL_PROMM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMT_0715
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligasePRO_0000152064Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT0715.

Structurei

3D structure databases

ProteinModelPortaliQ7TV01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi56 – 6611"HIGH" regionAdd
BLAST
Motifi630 – 6345"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TV01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTESFPSTSA SSQSSARYDP IELETRWQKE WLRQGLDRTP VAETNQKRFY
60 70 80 90 100
ALSMFPYPSG KLHMGHVRNY VITDVIARVQ RMRGDAVLHP MGWDAFGLPA
110 120 130 140 150
ENAAIARNVD PGDWTDQNIA QMRAQLDRLG LSIDWDRQQA TCHQDYYRWT
160 170 180 190 200
QWLFLELFAG GLAYQKEATV NWDPVDKTVL ANEQVDGEGR SWRSGALVEQ
210 220 230 240 250
RQLKQWFLRI TDYADALIDD LDELTGWPER VRTMQANWIG RSHGAEIKFR
260 270 280 290 300
VAGVANSIIT VFTTRPDTLH GASYVVLAPE HPLVESLTSP EQRLAVTAFC
310 320 330 340 350
DLISQLSVKD RTAEDQPKRG VPIGAQVINP VNGESLPVWI ADYVLADYGS
360 370 380 390 400
GAVMGVPAHD ERDFIFARSH ELPIRIVVQL PDTDEHHNDG QAWTGAGVLV
410 420 430 440 450
NSGAFDGLST EEAKVAITTH GASEGWAQSK VQYRLRDWLI SRQRYWGCPI
460 470 480 490 500
PIIHCASCGI VPVPQEDLPV TLPRDIDLSG KGGSPIAQEQ AWVEVKCPIC
510 520 530 540 550
GEKAHRETDT MDTFMCSSWY YLRFADPLNS QRPFDKDIVD EWLPVDQYVG
560 570 580 590 600
GIEHAILHLL YARFFTKALH DRNLIGFKEP FNRLLTQGMV QGLTYRNAKN
610 620 630 640 650
GSYISPELVS DDSDPRDPES GDRLEVLFEK MSKSKYNGVD PAVVIDRYGA
660 670 680 690 700
DTARMFILFK APPEKDLEWD DADVEGQFRF LQRLIRLIDS FAWPKTDGEN
710 720 730 740 750
ASISSANLII DSADLSEEEI NMRRATHKAI EAITEDLSGD IQLNTAISEL
760 770 780 790 800
MKLSNSLSGK LDKVRNEVAA EALSVLVRLM APFAPHLAEE FWLKLHGHGS
810 820 830 840 850
IHQQSWPVID PSALVLETIE LVIQVKGKVR GKIQVPANAD KKTLEELALN
860 870
SDIAVKWLEG QSPRRIIIVP GKLVNLVP
Length:878
Mass (Da):98,558
Last modified:October 1, 2003 - v1
Checksum:i344EA20A16DB279D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE20890.1.
RefSeqiNP_894547.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE20890; CAE20890; PMT_0715.
GeneIDi1729288.
KEGGipmt:PMT0715.
PATRICi23009405. VBIProMar135351_0857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE20890.1 .
RefSeqi NP_894547.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7TV01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT0715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20890 ; CAE20890 ; PMT_0715 .
GeneIDi 1729288.
KEGGi pmt:PMT0715.
PATRICi 23009405. VBIProMar135351_0857.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiSYL_PROMM
AccessioniPrimary (citable) accession number: Q7TV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3