Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7TTX6

- PUR9_SYNPX

UniProt

Q7TTX6 - PUR9_SYNPX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:SYNW0249
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Bifunctional purine biosynthesis protein PurHPRO_1000018979Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0249.

Structurei

3D structure databases

ProteinModelPortaliQ7TTX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TTX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPFALLSVS DKNGVVALAE ALHRTHGYAL LSSGGTAKVL EDAGLPVTRM
60 70 80 90 100
SEHNGAPEIL GGRVKTLHPR VHGGILAKRG DAAHQADLEQ QGIPAIDLVV
110 120 130 140 150
VNLYPFRETV ARADVTWDQA IENIDIGGPA MVRAAAKNHA DVAVLTSPDQ
160 170 180 190 200
YSSVLAAMAE SAGRVPADLC RQLALEAFQH TAAYDTAISR WMAGEVELVS
210 220 230 240 250
SPWLEAVPLR QTLRYGENPH QKARWFSHPR QGWGGAIQLQ GKELSTNNLL
260 270 280 290 300
DLEAALATVR EFGYGPNAVG PAAVVVKHTN PCGVAVGPVV ASALTRALDA
310 320 330 340 350
DRVSAFGGIV AINGPVEAAA ARELTGLFLE CVVAPSFSPE AREILAAKAN
360 370 380 390 400
LRLLELSPDA IAAAGPDHVR SILGGLLVQD LDDQVMTPDQ WTLATKRPPT
410 420 430 440 450
AQEKQDLEFA WRLVRHVRSN AIVVARDGQS LGVGAGQMNR VGSARIALEA
460 470 480 490 500
AAEKAKGAVL ASDGFFPFDD TVRLAASHGI TAVIHPGGSL RDGESVKACD
510
ELGLAMLLTG RRHFLH
Length:516
Mass (Da):54,509
Last modified:October 1, 2003 - v1
Checksum:i08B81AE6969A885A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569689 Genomic DNA. Translation: CAE06764.1.
RefSeqiNP_896344.1. NC_005070.1.
WP_011127125.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE06764; CAE06764; SYNW0249.
GeneIDi1730253.
KEGGisyw:SYNW0249.
PATRICi23831877. VBISynSp27240_0252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569689 Genomic DNA. Translation: CAE06764.1 .
RefSeqi NP_896344.1. NC_005070.1.
WP_011127125.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7TTX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE06764 ; CAE06764 ; SYNW0249 .
GeneIDi 1730253.
KEGGi syw:SYNW0249.
PATRICi 23831877. VBISynSp27240_0252.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiPUR9_SYNPX
AccessioniPrimary (citable) accession number: Q7TTX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3