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Q7TTX6

- PUR9_SYNPX

UniProt

Q7TTX6 - PUR9_SYNPX

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:SYNW0249
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Bifunctional purine biosynthesis protein PurHPRO_1000018979Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TTX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7TTX6-1 [UniParc]FASTAAdd to Basket

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    MAPFALLSVS DKNGVVALAE ALHRTHGYAL LSSGGTAKVL EDAGLPVTRM    50
    SEHNGAPEIL GGRVKTLHPR VHGGILAKRG DAAHQADLEQ QGIPAIDLVV 100
    VNLYPFRETV ARADVTWDQA IENIDIGGPA MVRAAAKNHA DVAVLTSPDQ 150
    YSSVLAAMAE SAGRVPADLC RQLALEAFQH TAAYDTAISR WMAGEVELVS 200
    SPWLEAVPLR QTLRYGENPH QKARWFSHPR QGWGGAIQLQ GKELSTNNLL 250
    DLEAALATVR EFGYGPNAVG PAAVVVKHTN PCGVAVGPVV ASALTRALDA 300
    DRVSAFGGIV AINGPVEAAA ARELTGLFLE CVVAPSFSPE AREILAAKAN 350
    LRLLELSPDA IAAAGPDHVR SILGGLLVQD LDDQVMTPDQ WTLATKRPPT 400
    AQEKQDLEFA WRLVRHVRSN AIVVARDGQS LGVGAGQMNR VGSARIALEA 450
    AAEKAKGAVL ASDGFFPFDD TVRLAASHGI TAVIHPGGSL RDGESVKACD 500
    ELGLAMLLTG RRHFLH 516
    Length:516
    Mass (Da):54,509
    Last modified:October 1, 2003 - v1
    Checksum:i08B81AE6969A885A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569689 Genomic DNA. Translation: CAE06764.1.
    RefSeqiNP_896344.1. NC_005070.1.
    WP_011127125.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE06764; CAE06764; SYNW0249.
    GeneIDi1730253.
    KEGGisyw:SYNW0249.
    PATRICi23831877. VBISynSp27240_0252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569689 Genomic DNA. Translation: CAE06764.1 .
    RefSeqi NP_896344.1. NC_005070.1.
    WP_011127125.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7TTX6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE06764 ; CAE06764 ; SYNW0249 .
    GeneIDi 1730253.
    KEGGi syw:SYNW0249.
    PATRICi 23831877. VBISynSp27240_0252.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiPUR9_SYNPX
    AccessioniPrimary (citable) accession number: Q7TTX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3