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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135L-tryptophanUniRule annotation1
Binding sitei191ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13ATPUniRule annotation3
Nucleotide bindingi19 – 20ATPUniRule annotation2
Nucleotide bindingi147 – 149ATPUniRule annotation3
Nucleotide bindingi200 – 204ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:SYNW1475
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366971 – 337Tryptophan--tRNA ligaseAdd BLAST337

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi84588.SYNW1475

Structurei

3D structure databases

ProteinModelPortaliQ7TTU9
SMRiQ7TTU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 20"HIGH" regionUniRule annotation9
Motifi200 – 204"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TTU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRPRVLSGV QPTGALHLGN WLGAIRNWVD LQDTHDTFVC VVDLHAITVP
60 70 80 90 100
HDPARLADDT LNTAALYLAC GMDPQRCSIF IQSQVAAHSE LCWLLNCVTP
110 120 130 140 150
LNWLERMIQF KEKAVKQGDN VSVGLLDYPV LMAADILLYD ADLVPVGEDQ
160 170 180 190 200
KQHLELARDI AQQRINARFG SEERPVLKVP KPLILKEGAR VMSLTDGRSK
210 220 230 240 250
MSKSDPNEGS RITLLDPPEL ITKKIKRAKT DPKRGLEFSN PDRPETDNLL
260 270 280 290 300
GLYAILSGKG REAAADECAD MGWGQFKPLL ADAAVAALEP IQARHKELMA
310 320 330
DRVELDRVLA KGRDQAESVA NASLERVRDA LGFAKCS
Length:337
Mass (Da):37,126
Last modified:October 1, 2003 - v1
Checksum:i6326A1A5871F8295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569693 Genomic DNA Translation: CAE07990.1
RefSeqiWP_011128339.1, NC_005070.1

Genome annotation databases

EnsemblBacteriaiCAE07990; CAE07990; SYNW1475
KEGGisyw:SYNW1475

Similar proteinsi

Entry informationi

Entry nameiSYW_SYNPX
AccessioniPrimary (citable) accession number: Q7TTU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health