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Protein

Microcephalin

Gene

Mcph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • bone development Source: MGI
  • cerebral cortex development Source: MGI
  • establishment of mitotic spindle orientation Source: MGI
  • mitotic cell cycle arrest Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuronal stem cell population maintenance Source: MGI
  • protein localization to centrosome Source: MGI
  • regulation of centrosome cycle Source: MGI
  • regulation of chromosome condensation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of kinase activity Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Microcephalin1 Publication
Gene namesi
Name:Mcph1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443308 Mcph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962991 – 822MicrocephalinAdd BLAST822

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1
Modified residuei329PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TT79
PaxDbiQ7TT79
PRIDEiQ7TT79

PTM databases

iPTMnetiQ7TT79
PhosphoSitePlusiQ7TT79

Expressioni

Tissue specificityi

High levels of expression are found in the developing forebrain and, in particular, in the walls of the lateral ventricles.1 Publication

Gene expression databases

BgeeiENSMUSG00000039842
CleanExiMM_MCPH1
ExpressionAtlasiQ7TT79 baseline and differential
GenevisibleiQ7TT79 MM

Interactioni

Subunit structurei

Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AFX under DNA damage conditions (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037000

Structurei

3D structure databases

ProteinModelPortaliQ7TT79
SMRiQ7TT79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 99BRCT 1PROSITE-ProRule annotationAdd BLAST90
Domaini627 – 717BRCT 2PROSITE-ProRule annotationAdd BLAST91
Domaini738 – 820BRCT 3PROSITE-ProRule annotationAdd BLAST83

Domaini

BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNF chromatin remodeling complex (By similarity).By similarity
BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, and mediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine and phosphotyrosine in the C-terminal tail of histone H2AFX (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4362 Eukaryota
ENOG41120NI LUCA
GeneTreeiENSGT00390000018842
HOGENOMiHOG000113501
HOVERGENiHBG052433
InParanoidiQ7TT79
KOiK19403
OMAiKCRTAGA
OrthoDBiEOG091G037P
PhylomeDBiQ7TT79
TreeFamiTF332942

Family and domain databases

CDDicd00027 BRCT, 2 hits
Gene3Di3.40.50.10190, 3 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR022047 Microcephalin-like
IPR029504 Microcephalin_mammal
PANTHERiPTHR14625 PTHR14625, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF12258 Microcephalin, 1 hit
PF12738 PTCB-BRCT, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 3 hits
SUPFAMiSSF52113 SSF52113, 3 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 3 hits

Sequencei

Sequence statusi: Complete.

Q7TT79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASGGVGGA FLKDVVAYVE VWSSKGTENY SRTFAKQLED MGATVSKTLN
60 70 80 90 100
KQVTHVIFKD GYQSTWDKAQ KTGAKLVSVL WVEKCRMAGA LVDESLFPAV
110 120 130 140 150
NTDEHLPNLS RKKHKCMQPK DFILKTPEND KRLQKKFEKM AEELQRQKAA
160 170 180 190 200
LDDDVPVLLF ESPRSLVYSS PVNVMKRRLQ DMKEKRENLS PTSSQMLEQS
210 220 230 240 250
QQNPCVSLFE TSLNISHQPL SSDESFASGS HSSFGDSCGD QERKLGRSAN
260 270 280 290 300
EMTTVTCPSS PVLRASSFYG SASPNHLRQP RPQKAPDSPS KESINCQKDA
310 320 330 340 350
TGAVADSERK QAAGVSQGVP DEKLCLSPTM SIIEEHQVRL GPKNSSAKRK
360 370 380 390 400
RAADLGSSPK GKLKKRYKRK SALAIQLFKS DQSPPSTIRL IPGTPDVEAS
410 420 430 440 450
SYEDYFSPDN LKERNSERLP PEAQQLASPS LFHCRGLSKW ERRNMLEMCD
460 470 480 490 500
FTCIGEKHRS ISSISDLISK SASSLEKPVK EEVNTASTCL LLVETSANDS
510 520 530 540 550
PGLCSQPGPQ LRDDTGPEGS SHPDTLSSSA HHITPLKGNS TETRDPGDGK
560 570 580 590 600
GSPKEGSTPP ASASPEDEVH ICNLSLGEDC NVEKSVEEKE NIATGYSESV
610 620 630 640 650
KNGPGRPDPS DSSCTGLVRP QQKPKKSEKE EKPTRTLVMT SMPSEKQTLI
660 670 680 690 700
IQVVSTLKGF SFAPEVCETT THVLVGKSAR TLNVLMGIAR GCWILSYEWV
710 720 730 740 750
LLSLELGHWI SEEPFELSET FPAAPICRLE RHLSTQQYQG TLFANQPKMF
760 770 780 790 800
IAPASSPPRA KLCELVLLCG GQVSPAPQLA SLIIGPYKGK KKARIQYLSE
810 820
KWVLDSITQH KICDFNNYQL LQ
Length:822
Mass (Da):90,373
Last modified:October 1, 2003 - v1
Checksum:iA2D92930A69968BE
GO

Sequence cautioni

The sequence BAC31136 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti726 – 742ICRLE…YQGTL → KYLSVSGQSDKVTWVLV in BAC31136 (PubMed:16141072).CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY070216 mRNA Translation: AAL50216.1
BC056924 mRNA Translation: AAH56924.1
AK042026 mRNA Translation: BAC31136.1 Different initiation.
AK083572 mRNA Translation: BAC38955.2
CCDSiCCDS22124.1
RefSeqiNP_775281.2, NM_173189.2
XP_017168280.1, XM_017312791.1
UniGeneiMm.235296

Genome annotation databases

EnsembliENSMUST00000039412; ENSMUSP00000037000; ENSMUSG00000039842
GeneIDi244329
KEGGimmu:244329
UCSCiuc009kzt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMCPH1_MOUSE
AccessioniPrimary (citable) accession number: Q7TT79
Secondary accession number(s): Q8BNI9, Q8C9I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health