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Protein

Microcephalin

Gene

Mcph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • bone development Source: MGI
  • cerebral cortex development Source: MGI
  • establishment of mitotic spindle orientation Source: MGI
  • mitotic cell cycle arrest Source: MGI
  • neuronal stem cell population maintenance Source: MGI
  • protein localization to centrosome Source: MGI
  • regulation of centrosome cycle Source: MGI
  • regulation of chromosome condensation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of kinase activity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Microcephalin
Gene namesi
Name:Mcph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443308. Mcph1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822MicrocephalinPRO_0000096299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei290 – 2901PhosphoserineCombined sources
Modified residuei327 – 3271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TT79.
PaxDbiQ7TT79.
PRIDEiQ7TT79.

PTM databases

iPTMnetiQ7TT79.
PhosphoSiteiQ7TT79.

Expressioni

Tissue specificityi

High levels of expression are found in the developing forebrain and, in particular, in the walls of the lateral ventricles.1 Publication

Gene expression databases

BgeeiQ7TT79.
CleanExiMM_MCPH1.
ExpressionAtlasiQ7TT79. baseline and differential.
GenevisibleiQ7TT79. MM.

Interactioni

Subunit structurei

Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AFX under DNA damage conditions (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037000.

Structurei

3D structure databases

ProteinModelPortaliQ7TT79.
SMRiQ7TT79. Positions 12-101, 634-818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9990BRCT 1PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 71791BRCT 2PROSITE-ProRule annotationAdd
BLAST
Domaini738 – 82083BRCT 3PROSITE-ProRule annotationAdd
BLAST

Domaini

BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNF chromatin remodeling complex (By similarity).By similarity
BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, and mediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine and phosphotyrosine in the C-terminal tail of histone H2AFX (By similarity).By similarity

Sequence similaritiesi

Contains 3 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4362. Eukaryota.
ENOG41120NI. LUCA.
GeneTreeiENSGT00390000018842.
HOGENOMiHOG000113501.
HOVERGENiHBG052433.
InParanoidiQ7TT79.
KOiK19403.
OMAiTQHKVCA.
OrthoDBiEOG7VX8X3.
PhylomeDBiQ7TT79.
TreeFamiTF332942.

Family and domain databases

Gene3Di3.40.50.10190. 3 hits.
InterProiIPR001357. BRCT_dom.
IPR022047. Microcephalin-like.
IPR029504. Microcephalin_mammal.
[Graphical view]
PANTHERiPTHR14625. PTHR14625. 1 hit.
PfamiPF16589. BRCT_2. 1 hit.
PF12258. Microcephalin. 1 hit.
PF12738. PTCB-BRCT. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 3 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 3 hits.
PROSITEiPS50172. BRCT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TT79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASGGVGGA FLKDVVAYVE VWSSKGTENY SRTFAKQLED MGATVSKTLN
60 70 80 90 100
KQVTHVIFKD GYQSTWDKAQ KTGAKLVSVL WVEKCRMAGA LVDESLFPAV
110 120 130 140 150
NTDEHLPNLS RKKHKCMQPK DFILKTPEND KRLQKKFEKM AEELQRQKAA
160 170 180 190 200
LDDDVPVLLF ESPRSLVYSS PVNVMKRRLQ DMKEKRENLS PTSSQMLEQS
210 220 230 240 250
QQNPCVSLFE TSLNISHQPL SSDESFASGS HSSFGDSCGD QERKLGRSAN
260 270 280 290 300
EMTTVTCPSS PVLRASSFYG SASPNHLRQP RPQKAPDSPS KESINCQKDA
310 320 330 340 350
TGAVADSERK QAAGVSQGVP DEKLCLSPTM SIIEEHQVRL GPKNSSAKRK
360 370 380 390 400
RAADLGSSPK GKLKKRYKRK SALAIQLFKS DQSPPSTIRL IPGTPDVEAS
410 420 430 440 450
SYEDYFSPDN LKERNSERLP PEAQQLASPS LFHCRGLSKW ERRNMLEMCD
460 470 480 490 500
FTCIGEKHRS ISSISDLISK SASSLEKPVK EEVNTASTCL LLVETSANDS
510 520 530 540 550
PGLCSQPGPQ LRDDTGPEGS SHPDTLSSSA HHITPLKGNS TETRDPGDGK
560 570 580 590 600
GSPKEGSTPP ASASPEDEVH ICNLSLGEDC NVEKSVEEKE NIATGYSESV
610 620 630 640 650
KNGPGRPDPS DSSCTGLVRP QQKPKKSEKE EKPTRTLVMT SMPSEKQTLI
660 670 680 690 700
IQVVSTLKGF SFAPEVCETT THVLVGKSAR TLNVLMGIAR GCWILSYEWV
710 720 730 740 750
LLSLELGHWI SEEPFELSET FPAAPICRLE RHLSTQQYQG TLFANQPKMF
760 770 780 790 800
IAPASSPPRA KLCELVLLCG GQVSPAPQLA SLIIGPYKGK KKARIQYLSE
810 820
KWVLDSITQH KICDFNNYQL LQ
Length:822
Mass (Da):90,373
Last modified:October 1, 2003 - v1
Checksum:iA2D92930A69968BE
GO

Sequence cautioni

The sequence BAC31136.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti726 – 74217ICRLE…YQGTL → KYLSVSGQSDKVTWVLV in BAC31136 (PubMed:16141072).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY070216 mRNA. Translation: AAL50216.1.
BC056924 mRNA. Translation: AAH56924.1.
AK042026 mRNA. Translation: BAC31136.1. Different initiation.
AK083572 mRNA. Translation: BAC38955.2.
CCDSiCCDS22124.1.
RefSeqiNP_775281.2. NM_173189.2.
UniGeneiMm.235296.

Genome annotation databases

EnsembliENSMUST00000039412; ENSMUSP00000037000; ENSMUSG00000039842.
GeneIDi244329.
KEGGimmu:244329.
UCSCiuc009kzt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY070216 mRNA. Translation: AAL50216.1.
BC056924 mRNA. Translation: AAH56924.1.
AK042026 mRNA. Translation: BAC31136.1. Different initiation.
AK083572 mRNA. Translation: BAC38955.2.
CCDSiCCDS22124.1.
RefSeqiNP_775281.2. NM_173189.2.
UniGeneiMm.235296.

3D structure databases

ProteinModelPortaliQ7TT79.
SMRiQ7TT79. Positions 12-101, 634-818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037000.

PTM databases

iPTMnetiQ7TT79.
PhosphoSiteiQ7TT79.

Proteomic databases

MaxQBiQ7TT79.
PaxDbiQ7TT79.
PRIDEiQ7TT79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039412; ENSMUSP00000037000; ENSMUSG00000039842.
GeneIDi244329.
KEGGimmu:244329.
UCSCiuc009kzt.1. mouse.

Organism-specific databases

CTDi79648.
MGIiMGI:2443308. Mcph1.

Phylogenomic databases

eggNOGiKOG4362. Eukaryota.
ENOG41120NI. LUCA.
GeneTreeiENSGT00390000018842.
HOGENOMiHOG000113501.
HOVERGENiHBG052433.
InParanoidiQ7TT79.
KOiK19403.
OMAiTQHKVCA.
OrthoDBiEOG7VX8X3.
PhylomeDBiQ7TT79.
TreeFamiTF332942.

Miscellaneous databases

PROiQ7TT79.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TT79.
CleanExiMM_MCPH1.
ExpressionAtlasiQ7TT79. baseline and differential.
GenevisibleiQ7TT79. MM.

Family and domain databases

Gene3Di3.40.50.10190. 3 hits.
InterProiIPR001357. BRCT_dom.
IPR022047. Microcephalin-like.
IPR029504. Microcephalin_mammal.
[Graphical view]
PANTHERiPTHR14625. PTHR14625. 1 hit.
PfamiPF16589. BRCT_2. 1 hit.
PF12258. Microcephalin. 1 hit.
PF12738. PTCB-BRCT. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 3 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 3 hits.
PROSITEiPS50172. BRCT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J X CBA/J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-742.
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiMCPH1_MOUSE
AccessioniPrimary (citable) accession number: Q7TT79
Secondary accession number(s): Q8BNI9, Q8C9I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.