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Protein

Lengsin

Gene

Lgsn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Lengsin
Alternative name(s):
Glutamate-ammonia ligase domain-containing protein 1
Lens glutamine synthase-like
Gene namesi
Name:Lgsn
Synonyms:Gluld1, Lgs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi727925 Lgsn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532841 – 561LengsinAdd BLAST561

Proteomic databases

PaxDbiQ7TT51
PRIDEiQ7TT51

Expressioni

Tissue specificityi

Expressed in lens.

Gene expression databases

BgeeiENSRNOG00000012205

Interactioni

Subunit structurei

Dodecamer. Interacts with BFSP2 AND VIM.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016316

Structurei

3D structure databases

ProteinModelPortaliQ7TT51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiKOG0683 Eukaryota
COG0174 LUCA
GeneTreeiENSGT00390000013639
HOGENOMiHOG000113321
HOVERGENiHBG051740
InParanoidiQ7TT51
OMAiTFYTHPE
OrthoDBiEOG091G0IKF
PhylomeDBiQ7TT51
TreeFamiTF331605

Family and domain databases

Gene3Di3.10.20.70, 1 hit
InterProiView protein in InterPro
IPR036651 Gln_synt_N
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR008146 Gln_synth_cat_dom
PfamiView protein in Pfam
PF00120 Gln-synt_C, 1 hit
SMARTiView protein in SMART
SM01230 Gln-synt_C, 1 hit
SUPFAMiSSF54368 SSF54368, 1 hit
SSF55931 SSF55931, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TT51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDEGDLAQE DTTKDEANST EGSRVNKLKR TRRKVTKPHL CSADGDEITM
60 70 80 90 100
ANSREMSRNQ TADLSKPGSA ESWSWHNAKD AQDQIPVVKS SLPSAGAPDA
110 120 130 140 150
EFNPNTDHTR DNAQSLILPQ LSSRMKHIKQ EMAKNHLQFV RFEATDLHGV
160 170 180 190 200
SRSKSIPAQF FQEKVIHGVF MPRGYLELMP NPKDNEVNHI RATCFNSDIV
210 220 230 240 250
LMPELSTFRV LPWAERTARV ICDTFTVTGE PLLTSPRYIA KRQLRQLQDA
260 270 280 290 300
GFSLLSAFIY DFCIFGVPEV INSKTISFPA STLLSNHDQP FMQELVDGLY
310 320 330 340 350
HTGANVESFS SSTRPGQMEI CFLPEFGISS ADNAFTLRTG VQEVARRYNY
360 370 380 390 400
IASLVIETGF CNSGILSHSI WDVSGKTNMF YSGSGVERLT LTGKKWLAGL
410 420 430 440 450
LKHSAALSCL MAPAVNCRKR YCKDSRDLKD SVPTTWGYND NSCALNVKCH
460 470 480 490 500
GEKGTQIENK LGSATANPYL VLAATVAAGL DGLQSSDGAA AESDESQDLY
510 520 530 540 550
QPEPSEIPLK MEDALAALEQ DECLKQALGE TFIRYFVAMK KYELENEETD
560
AEGNKFLEYF I
Length:561
Mass (Da):62,269
Last modified:October 1, 2003 - v1
Checksum:iF3BE12C50751DDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280501 mRNA Translation: AAP34385.1
RefSeqiNP_852048.1, NM_181383.2
XP_017451926.1, XM_017596437.1
UniGeneiRn.38685

Genome annotation databases

EnsembliENSRNOT00000016316; ENSRNOP00000016316; ENSRNOG00000012205
GeneIDi316304
KEGGirno:316304
UCSCiRGD:727925 rat

Similar proteinsi

Entry informationi

Entry nameiLGSN_RAT
AccessioniPrimary (citable) accession number: Q7TT51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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