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Protein

Lengsin

Gene

Lgsn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lengsin
Alternative name(s):
Glutamate-ammonia ligase domain-containing protein 1
Lens glutamine synthase-like
Gene namesi
Name:Lgsn
Synonyms:Gluld1, Lgs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi727925. Lgsn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561LengsinPRO_0000153284Add
BLAST

Proteomic databases

PaxDbiQ7TT51.
PRIDEiQ7TT51.

Expressioni

Tissue specificityi

Expressed in lens.

Interactioni

Subunit structurei

Dodecamer. Interacts with BFSP2 AND VIM.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016316.

Structurei

3D structure databases

ProteinModelPortaliQ7TT51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiKOG0683. Eukaryota.
COG0174. LUCA.
GeneTreeiENSGT00390000013639.
HOGENOMiHOG000113321.
HOVERGENiHBG051740.
InParanoidiQ7TT51.
OMAiHASEITY.
OrthoDBiEOG7MWGW7.
PhylomeDBiQ7TT51.
TreeFamiTF331605.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TT51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDEGDLAQE DTTKDEANST EGSRVNKLKR TRRKVTKPHL CSADGDEITM
60 70 80 90 100
ANSREMSRNQ TADLSKPGSA ESWSWHNAKD AQDQIPVVKS SLPSAGAPDA
110 120 130 140 150
EFNPNTDHTR DNAQSLILPQ LSSRMKHIKQ EMAKNHLQFV RFEATDLHGV
160 170 180 190 200
SRSKSIPAQF FQEKVIHGVF MPRGYLELMP NPKDNEVNHI RATCFNSDIV
210 220 230 240 250
LMPELSTFRV LPWAERTARV ICDTFTVTGE PLLTSPRYIA KRQLRQLQDA
260 270 280 290 300
GFSLLSAFIY DFCIFGVPEV INSKTISFPA STLLSNHDQP FMQELVDGLY
310 320 330 340 350
HTGANVESFS SSTRPGQMEI CFLPEFGISS ADNAFTLRTG VQEVARRYNY
360 370 380 390 400
IASLVIETGF CNSGILSHSI WDVSGKTNMF YSGSGVERLT LTGKKWLAGL
410 420 430 440 450
LKHSAALSCL MAPAVNCRKR YCKDSRDLKD SVPTTWGYND NSCALNVKCH
460 470 480 490 500
GEKGTQIENK LGSATANPYL VLAATVAAGL DGLQSSDGAA AESDESQDLY
510 520 530 540 550
QPEPSEIPLK MEDALAALEQ DECLKQALGE TFIRYFVAMK KYELENEETD
560
AEGNKFLEYF I
Length:561
Mass (Da):62,269
Last modified:October 1, 2003 - v1
Checksum:iF3BE12C50751DDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280501 mRNA. Translation: AAP34385.1.
RefSeqiNP_852048.1. NM_181383.2.
UniGeneiRn.38685.

Genome annotation databases

EnsembliENSRNOT00000016316; ENSRNOP00000016316; ENSRNOG00000012205.
GeneIDi316304.
KEGGirno:316304.
UCSCiRGD:727925. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280501 mRNA. Translation: AAP34385.1.
RefSeqiNP_852048.1. NM_181383.2.
UniGeneiRn.38685.

3D structure databases

ProteinModelPortaliQ7TT51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016316.

Proteomic databases

PaxDbiQ7TT51.
PRIDEiQ7TT51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016316; ENSRNOP00000016316; ENSRNOG00000012205.
GeneIDi316304.
KEGGirno:316304.
UCSCiRGD:727925. rat.

Organism-specific databases

CTDi51557.
RGDi727925. Lgsn.

Phylogenomic databases

eggNOGiKOG0683. Eukaryota.
COG0174. LUCA.
GeneTreeiENSGT00390000013639.
HOGENOMiHOG000113321.
HOVERGENiHBG051740.
InParanoidiQ7TT51.
OMAiHASEITY.
OrthoDBiEOG7MWGW7.
PhylomeDBiQ7TT51.
TreeFamiTF331605.

Miscellaneous databases

NextBioi670682.
PROiQ7TT51.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Wistow G.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Eye.

Entry informationi

Entry nameiLGSN_RAT
AccessioniPrimary (citable) accession number: Q7TT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.