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Protein

Paraplegin

Gene

Spg7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

ATP-dependent zinc metalloprotease.Curated

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei312ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei492ATPBy similarity1
Metal bindingi537Zinc; catalyticBy similarity1
Active sitei538By similarity1
Metal bindingi541Zinc; catalyticBy similarity1
Metal bindingi613Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Paraplegin (EC:3.4.24.-)
Gene namesi
Name:Spg7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi727940. Spg7.

Subcellular locationi

  • Mitochondrion membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049331 – 744ParapleginAdd BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei505Nitrated tyrosineBy similarity1

Keywords - PTMi

Nitration

Proteomic databases

PaxDbiQ7TT47.
PRIDEiQ7TT47.

PTM databases

SwissPalmiQ7TT47.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015150.
ExpressionAtlasiQ7TT47. baseline and differential.
GenevisibleiQ7TT47. RN.

Interactioni

Subunit structurei

Interacts with AFG3L2; the interaction is required for the efficient assembly of mitochondrial complex I. Interacts with MAIP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048848.

Structurei

3D structure databases

ProteinModelPortaliQ7TT47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
GeneTreeiENSGT00860000133879.
HOGENOMiHOG000217277.
HOVERGENiHBG050184.
InParanoidiQ7TT47.
KOiK09552.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TT47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALLLLRA LRQSPEPGPW RLWAQLSGRS PGLFSGAGGR RPYVVRGTPI
60 70 80 90 100
GLAAAGGHTP QSLLLRILTP SFEGVSGLLL KRHIVPSAIR LWQLSGSTLY
110 120 130 140 150
FNTSGLKQKN KDDDKPKGKA PEDDEEERRR KEREDQMYRE RLRTLFIIAI
160 170 180 190 200
VMSLLNSLST SGGSISWADF VNEMLAKGEV QRVQVVPESD VVEVYLHPGA
210 220 230 240 250
VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIESKDR IPVSYKRTGF
260 270 280 290 300
FGNALYALGM TAVGLAILWY VFRLAGMTGR EGGFSAFNQL KMARFTIVDG
310 320 330 340 350
KTGKGVSFQD VAGMHEAKLE VREFVDYLKS PERFLQLGAK VPKGALLLGP
360 370 380 390 400
PGCGKTLLAK AVATEAQVPF LAMAGPEFVE VIGGLGAARV RSLFKEARAR
410 420 430 440 450
APCIVYIDEI DAVGKKRSTS MSGFSNTEEE QTLNQLLVEM DGMGTADHVI
460 470 480 490 500
VLASTNRADV LDNALMRPGR LDRHVFIDLP TLQERREIFE QHLKGLKLTQ
510 520 530 540 550
PSSFYSQRLA ELTPGFSGTA KKSKILSKEE QRVVAFHESG HALVGWLLEH
560 570 580 590 600
TEAVMKVSIA PRTNAALGFS QMLPRDQYLF TKEQLFERMC MALGGRAAEA
610 620 630 640 650
ISFSRVTSGA QDDLRKVTRI AYSMVKQFGM APSIGPVSFP EAQEGLVGIG
660 670 680 690 700
RRPFSQGLQQ MMDHEARLLV ARAYRHTEKV LLDNLDKLQA LANALLEKEV
710 720 730 740
INYEDIEALI GPPPHGPKKM IAPQKWIDAE KEKQASGEEE APAP
Length:744
Mass (Da):82,123
Last modified:October 1, 2003 - v1
Checksum:i82E6F800C358D8E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278739 mRNA. Translation: AAP35059.1.
RefSeqiNP_852053.1. NM_181388.2.
UniGeneiRn.16437.

Genome annotation databases

EnsembliENSRNOT00000047754; ENSRNOP00000048848; ENSRNOG00000015150.
GeneIDi353231.
KEGGirno:353231.
UCSCiRGD:727940. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278739 mRNA. Translation: AAP35059.1.
RefSeqiNP_852053.1. NM_181388.2.
UniGeneiRn.16437.

3D structure databases

ProteinModelPortaliQ7TT47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048848.

Protein family/group databases

MEROPSiM41.006.

PTM databases

SwissPalmiQ7TT47.

Proteomic databases

PaxDbiQ7TT47.
PRIDEiQ7TT47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047754; ENSRNOP00000048848; ENSRNOG00000015150.
GeneIDi353231.
KEGGirno:353231.
UCSCiRGD:727940. rat.

Organism-specific databases

CTDi6687.
RGDi727940. Spg7.

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
GeneTreeiENSGT00860000133879.
HOGENOMiHOG000217277.
HOVERGENiHBG050184.
InParanoidiQ7TT47.
KOiK09552.

Miscellaneous databases

PROiQ7TT47.

Gene expression databases

BgeeiENSRNOG00000015150.
ExpressionAtlasiQ7TT47. baseline and differential.
GenevisibleiQ7TT47. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPG7_RAT
AccessioniPrimary (citable) accession number: Q7TT47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.