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Protein

DBH-like monooxygenase protein 2

Gene

Moxd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei209Sequence analysis1
Metal bindingi241Copper ABy similarity1
Metal bindingi242Copper ABy similarity1
Metal bindingi309Copper ABy similarity1
Active sitei390Sequence analysis1
Metal bindingi390Copper BBy similarity1
Metal bindingi392Copper BBy similarity1
Metal bindingi465Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DBH-like monooxygenase protein 2 (EC:1.14.17.-)
Alternative name(s):
Dopamine-beta-hydroxylase-like protein
Gene namesi
Name:Moxd2
Synonyms:Dbhl, Dbhl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2388042 Moxd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 594ExtracellularSequence analysisAdd BLAST573
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Topological domaini616 – 619CytoplasmicSequence analysis4

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000030522422 – 619DBH-like monooxygenase protein 2Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi211 ↔ 261By similarity
Disulfide bondi248 ↔ 271By similarity
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi366 ↔ 481By similarity
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi444 ↔ 466By similarity
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TT41
PRIDEiQ7TT41
TopDownProteomicsiQ7TT41

Expressioni

Tissue specificityi

Expressed at low levels in thymus and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000029885
CleanExiMM_MOXD2
GenevisibleiQ7TT41 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031937

Structurei

3D structure databases

ProteinModelPortaliQ7TT41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 156DOMONPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3568 Eukaryota
ENOG410XR89 LUCA
GeneTreeiENSGT00530000063085
HOGENOMiHOG000004745
HOVERGENiHBG099586
InParanoidiQ7TT41
OMAiCYGADPA
OrthoDBiEOG091G06B3
PhylomeDBiQ7TT41
TreeFamiTF320698

Family and domain databases

Gene3Di2.60.120.230, 1 hit
2.60.120.310, 1 hit
InterProiView protein in InterPro
IPR014784 Cu2_ascorb_mOase-like_C
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR005018 DOMON_domain
IPR028464 Moxd2
IPR008977 PHM/PNGase_F_dom_sf
IPR028460 Tbh/DBH
PANTHERiPTHR10157:SF31 PTHR10157:SF31, 1 hit
PfamiView protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF03351 DOMON, 1 hit
PRINTSiPR00767 DBMONOXGNASE
SMARTiView protein in SMART
SM00664 DoH, 1 hit
SUPFAMiSSF49742 SSF49742, 2 hits
PROSITEiView protein in PROSITE
PS50836 DOMON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TT41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACVLLFRLF LLLVLAAFSQ GKRLGPTSPL RYSRFLDPSR AVFLRWDFDY
60 70 80 90 100
EAEIITFELQ VQTTGWVGLG ITDRYTFVGS DLVVGGVLPN GNVYFSDQHL
110 120 130 140 150
LDEDTLEQDG SQDAELLRLT EDAVSTTMRF SRPFRTCDPH DRDITSDTMR
160 170 180 190 200
VLAAYGPDDI PKMSREHTFV KSIFLLQMLQ YDDQDAPEDT IIHDLKISNF
210 220 230 240 250
IIPEDDTTYA CTFLPLPIVS KKHHIYKFEP ILVERNETMV HHVLVYACGN
260 270 280 290 300
SSVLPTGIGE CYGSDPAFSL CSHVIAGWAV GGLSYQFPDD VGISIGTPFD
310 320 330 340 350
PQWIRLEIHY SNFQNLPGIR DTSGMRLFYT SHLRKYDMGV LQLGISVFPI
360 370 380 390 400
HFIPPGAEAF LSYGLCKTDK FEELNGAPVS DIYISACLLH THLAGRSLQA
410 420 430 440 450
LQYRNGTQLQ VVCKDFSYDF NLQESRDLPH PVVIKPGDEL LIECHYQTLD
460 470 480 490 500
RDFMTFGGAS TINEMCLIFF FYYPRINISS CMGYPDIIYV TNELGEEASE
510 520 530 540 550
NPMENLMVLD NVEWTPENIK KAEKACKESQ QTVLIKTIDE EVENTTGWIP
560 570 580 590 600
DIIPTPRGPC LESTGGKVEP QDNTPAGFRA VPLALSGSNT ATLRPLPMIA
610
VLFLQGSLSC LLAMLQTGV
Length:619
Mass (Da):69,397
Last modified:October 1, 2003 - v1
Checksum:i74518832AD5E1A63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289D → G in BAB62024 (Ref. 2) Curated1
Sequence conflicti561L → V in BAB62024 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000663 Genomic DNA Translation: AAB69054.1
AB065134 mRNA Translation: BAB62024.1
CCDSiCCDS20039.1
RefSeqiNP_647457.2, NM_139296.2
UniGeneiMm.207087

Genome annotation databases

EnsembliENSMUST00000031937; ENSMUSP00000031937; ENSMUSG00000029885
GeneIDi194357
KEGGimmu:194357
UCSCiuc009bnh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMOXD2_MOUSE
AccessioniPrimary (citable) accession number: Q7TT41
Secondary accession number(s): Q91XT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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